[1]吕雅云,龚先琼.女贞子提取物治疗肝病的研究[J].医学信息,2020,33(03):31-33,37.[doi:10.3969/j.issn.1006-1959.2020.03.010]
 LYU Ya-yun,GONG Xian-qiong.Study on Ligustrum Lucidum Extract in Treating Liver Disease[J].Medical Information,2020,33(03):31-33,37.[doi:10.3969/j.issn.1006-1959.2020.03.010]
点击复制

女贞子提取物治疗肝病的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年03期
页码:
31-33,37
栏目:
综述
出版日期:
2020-02-01

文章信息/Info

Title:
Study on Ligustrum Lucidum Extract in Treating Liver Disease
文章编号:
1006-1959(2020)03-0031-04
作者:
吕雅云龚先琼
(1.福建中医药大学,福建 福州 351012;2.福建中医药大学附属厦门中医院,福建 厦门 361009)
Author(s):
LYU Ya-yun1GONG Xian-qiong2
(1.Fujian University of Traditional Chinese Medicine,Fuzhou 351012,Fujian,China;2.Xiamen Traditional Chinese Medicine Hospital,Fujian University of Traditional Chinese Medicine,Xiamen 361009,Fujian,China)
关键词:
女贞子齐墩果酸芹菜素红景天苷肝损伤
Keywords:
Ligustrum lucidumOleanolic acidApigeninSalidrosideLiver injury
分类号:
R285.5
DOI:
10.3969/j.issn.1006-1959.2020.03.010
文献标志码:
A
摘要:
女贞子的主要提取物具有抗炎、抗氧化、调节免疫等多种生物活性,对不同原因导致的肝损伤可多靶点、多通路地发挥保护作用。本文就女贞子提取物红景天苷、齐墩果酸、芹菜素、特女贞苷在治疗肝病中的研究进行综述,以期为女贞子及其有效成分在临床治疗肝病的应用提供理论参考。
Abstract:
The main extract of Ligustrum lucidum has a variety of biological activities such as anti-inflammatory, anti-oxidation, and regulation of immunity. It can protect the liver damage caused by different reasons with multiple targets and multiple pathways. This article reviews the researches of Ligustrum lucidum extract, salidroside, oleanolic acid, apigenin, and ligustrin in the treatment of liver diseases, in order to provide a theory for the application of ligustrum and its active ingredients in clinical treatment of liver diseases reference.

参考文献/References:

[1]张娜娜,张振巍,石磊.女贞子抗肿瘤活性成分提取工艺考察[J].中国药师,2015,18(2):215-219. [2]谭文广,刘伟,鲁菲菲,等.女贞子中三萜化合物的提取与含量测定[J].食品科学,2006,27(11):260-262. [3]杨阳,易骏,马利,等.多指标正交试验优化女贞子中环烯醚萜苷的提取工艺[J].中国药房,2016,27(28):3970-3973. [4]徐小花,杨念云,钱士辉,等.女贞子黄酮类化合物的研究[J].中药材,2007,30(5):538-540. [5]张立海,宋友华,孙春华,等.反相高效液相色谱法测定女贞子中红景天苷的含量[J].中国药学杂志,2001,36(11):42-43. [6]Lin SY,Dan X,Du XX,et al.Protective Effects of Salidroside against Carbon Tetrachloride (CCl4)-Induced Liver Injury by Initiating Mitochondria to Resist Oxidative Stress in Mice[J]. Int J Mol Sci,2019,20(13):3187. [7]Feng J,Zhang Q,Mo W,et al.Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice[J].Drug Des Devel Ther,2017(11):1989-2006. [8]Cai L,Li Y,Zhang Q,et al.Salidroside protects rat liver against ischemiareperfusion injury by regulating the GSK-3β/Nrf-2-dependent antioxidant response and mitochondrial permeability transition[J].Eur J Pharmacol,2017(806):32-42. [9]Lonardo A,Ballestri S,Marchesini G,et al.Nonalcoholic fatty liver disease:A precursor of the metabolic syndrome[J].Dig Liver Dis,2015,47(3):181-190. [10]Asrih M,Jornayvaz FR.Metabolic syndrome and nonalcoholic fatty liver disease:Is insulin resistance the link[J].Mol Cell Endocrinol,2015(418):55-65. [11]Castro GS,Cardoso JF,Vannucchi H,et al.Fructose and NAFLD:metabolic implications and models of induction in rats[J].Acta Cir Bras,2011(26 Suppl 2):45-50. [12]Yang ZR,Wang HF,Zuo TC,et al.Salidroside alleviates oxidative stress in the liver with non- alcoholic steatohepatitis in rats[J].BMC Pharmacol Toxicol,2016,17(1):16. [13]Zheng T,Yang X,Li W,et al.Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway[J].Oxid Med Cell Longev,2018(2018):1-17. [14]Feng J,Chen K,Xia Y,et al.Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-kB and TGF-β1/Smad3 pathways[J].Drug Des Devel Ther,2018(12):1837-1853. [15]吕红梅,张庆江.红景天苷对人肝癌HepG-2细胞MMP-1的表达及粘附能力的影响[J].中医药学报,2015,43(4):65-66. [16]Lu L,Liu S,Dong Q,et al.Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway[J].Mol Med Rep,2019,19(6):4964-4972. [17]Wan XL,Lu YF,Xu SF,et al.Oeanolic acid protects against the hepatotoxicity of D-galactosame plus endotoxin in mice[J].Biomed Pharmacother,2017(93):1040-1046. [18]Wang W,Wu L,Li J,et al.Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy[J].Mediators Inflamm,2019(2019):1-10. [19]Hao BB,Pan XX,Fan Y,et al.Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway[J].Hepatobiliary Pancreat Dis Int,2016,15(5):519-524. [20]Valic Z,Tappy L, Lê KA,et al.Metabolic Effects of Fructose and the Worldwide Increase in Obesity[J].Journal of Applied Physiology,2001,90(1):23-28,46. [21]Postic C,Girard J.Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance:lessons from genetically engineered mice[J].J Clin Invest,2008,118(3):829-838. [22]Liu C,Li Y,Zuo G,et al.Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats: Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis[J].Evid Based Complement Alternat Med,2013(2013):1-11. [23]Zhou RJ,Ye H,Wang F,et al.Apigenin inhibits d -galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice[J].Biochem Biophys Res Commun,2017,493(1):625-630. [24]Tsaroucha AK,Tsiaousidou A,Ouzounidis N,et al.Intraperitoneal administration of apigenin in liver ischemiareperfusion injury protective effects[J].Saudi J Gastroenterol,2016,22(6):415. [25]Lv Y,Gao X,Luo Y,et al.Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways[J].J Nutr Biochem,2019(71):110-121. [26]Hicks DF,Goossens N,Blas-García A,et al.Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells[J].Sci Rep,2017,7(1):42563. [27]庄让笑,潘旭旺,方红英,等.芹菜素纳米乳抗大鼠肝纤维化作用及对MMP-1,TIMP-1的影响[J].中国临床药理学与治疗学,2016,21(10):1122-1125. [28]Yang J,Pi C,Wang G.Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells[J].Biomedicine&Pharmacotherapy,2018(103):699-707. [29]胡冬梅.特女贞苷对四氯化碳致小鼠急性肝损伤的保护作用及其机制研究[D].西北大学,2017.

更新日期/Last Update: 2020-02-01