[1]姜 博,刘 艳.FPG和HbA1c对急性脑梗死合并2型糖尿病患者静脉溶栓效果的影响[J].医学信息,2020,33(08):118-119.[doi:10.3969/j.issn.1006-1959.2020.08.037]
　JIANG Bo,LIU Yan.Effects of FPG and HbA1c on the Efficacy of Intravenous Thrombolysis in Patients with Acute Cerebral Infarction and Type 2 Diabetes[J].Medical Information,2020,33(08):118-119.[doi:10.3969/j.issn.1006-1959.2020.08.037]
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FPG和HbA1c对急性脑梗死合并2型糖尿病患者静脉溶栓效果的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年08期
页码:
118-119
栏目:
临床研究
出版日期:
2020-04-15

文章信息/Info

Title:
Effects of FPG and HbA1c on the Efficacy of Intravenous Thrombolysis in Patients with Acute Cerebral Infarction and Type 2 Diabetes
文章编号:
1006-1959（2020）08-0118-02
作者:
姜 博; 刘 艳
（黑龙江省佳木斯市中心医院神经内1科，黑龙江 佳木斯 154002）
Author(s):
JIANG Bo; LIU Yan
(Department of Neurology,Subject One,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
血糖; 糖化血红蛋白; 急性脑梗死; 2型糖尿病; 溶栓
Keywords:
Blood glucose; Glycated hemoglobin; Acute cerebral infarction; Type 2 diabetes; Thrombolysis
分类号:
R743.3； R587.1
DOI:
10.3969/j.issn.1006-1959.2020.08.037
文献标志码:
A
摘要:
目的 研究急性脑梗死合并2型糖尿病患者FPG和HbA1c水平对静脉溶栓效果的影响。方法 选取2018年4月~2019年4月我院诊治的急性脑梗死患者84例，依据是否合并2型糖尿病分为合并组（46例）和未合并组（38例），均予阿替普酶溶栓治疗。比较两组FPG、HbA1c、TG、LDL-C、24 h平均血糖、血糖水平标准差、平均血糖波动幅度、神经功能缺损（NIHSS）评分、Bqrthel指数、颅内出血发生情况、血管再通率及溶栓前FPG和HbA1c对溶栓效果的影响。结果 治疗后合并组FPG、HbA1c、TG、LDL-C、24 h平均血糖、血糖水平标准差、平均血糖波动幅度均高于未合并组（P＜0.05）；合并组NIHSS评分高于未合并组，Bqrthel指数、血管再通率均低于未合并组（P＜0.05）；两组颅内出血发生率比较，差异无统计学意义（P＞0.05）；合并组FPG＜6.0 mmol/L或＞7.0 mmol/L时24 h有效率最低（28.57%）、（16.67%），7.0~9.0 mmol/L或HbA1c＜6.0 mmol/L时，24 h有效率最高（73.33%）、（63.33%）。结论 急性脑梗死合并2型糖尿病阿替普酶溶栓治疗效果受FPG水平影响，且HbA1c越高疗效越差，溶栓治疗有助于改善神经功能，但不能提高血管再通率，在溶栓前将血糖控制在7.0~9.0mmol/L有利于提高溶栓总有效率。
Abstract:
Objective To study the effect of fasting blood glucose (FPG) and glycated hemoglobin (HbA1c) levels on venous thrombolysis in patients with acute cerebral infarction and type 2 diabetes.Methods 84 patients with acute cerebral infarction diagnosed and treated in our hospital from April 2018 to April 2019 were selected, and divided into a combined group (46 cases) and an uncombined group (38 cases) according to whether they had type 2 diabetes,all were given alteplase thrombolytic therapy. Compare the two groups of FPG, HbA1c, TG, LDL-C, 24 h average blood glucose, standard deviation of blood glucose level, average blood glucose fluctuation amplitude, neurological deficit (NIHSS) score, Bqrthel index, incidence of intracranial hemorrhage, vascular recanalization rate, and the effect of FPG and HbA1c before thrombolysis on thrombolytic effect.Results After treatment, FPG, HbA1c, TG and LDL-C，the 24 h average blood glucose, standard deviation of blood glucose level, and average blood glucose fluctuation of the combined group were higher than those of the uncombined group(P＜0.05); the NIHSS score of the combined group was higher than that of the uncombined group, and the Bqrthel index and vascular recanalization rate were lower than those of the uncombined group (P＜0.05); There was no significant difference in the incidence of intracranial hemorrhage between the two groups(P＞0.05); When FPG＜6.0 mmol/L or HbA1c＞7.0 mmol/L in the combined group, the lowest effective rate is 24 h(28.57%) and(16.67%), when 7.0~9.0 mmol/L or, HbA1c＜6.0 mmol/L， the highest effective rate is 24 h(73.33%) and(63.33%). Conclusion The effect of thrombolytic therapy for acute cerebral infarction with type 2 diabetes is affected by the level of FPG, and the higher the HbA1c, the worse the effect. Thrombolytic therapy can help improve nerve function, but it cannot improve the rate of vascular recanalization. Before thrombolysis Controlling blood glucose at 7.0~9.0 mmol/L is conducive to improving the total efficiency of thrombolysis.

参考文献/References:

[1]张蕴.血糖及糖化蛋白与急性脑梗死临床关系的探讨[J].临床神经病学杂志,2014,11(3):165.[2]高桂兰,吴卫平,尹岭,等.急性脑血管病糖化血红蛋白的临床意义[J].脑与神经病杂志,2014,6(6):356-357[3]张名扬,吕肖锋,张麵,等.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激水平的影响及意义[J].中国全科医学,2014,17(7):784-787.[4]于海龙,李军,徐耀,等.急性脑梗死合并2型糖尿病患者超早期rt-PA静脉溶栓的效果分析[J].实用临床医药杂志,2014,18(21):20-22.

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更新日期/Last Update: 2020-04-15