[1]王 晶.垂体后叶素联合硝酸甘油治疗肝硬化上消化道出血的效果[J].医学信息,2020,33(19):147-148151.[doi:10.3969/j.issn.1006-1959.2020.19.046]
　WANG Jing.Effect of Pituitrin and Nitroglycerin on Upper Gastrointestinal Bleeding in Cirrhosis[J].Medical Information,2020,33(19):147-148151.[doi:10.3969/j.issn.1006-1959.2020.19.046]
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垂体后叶素联合硝酸甘油治疗肝硬化上消化道出血的效果()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年19期
页码:
147-148151
栏目:
药物与临床
出版日期:
2020-10-01

文章信息/Info

Title:
Effect of Pituitrin and Nitroglycerin on Upper Gastrointestinal Bleeding in Cirrhosis
文章编号:
1006-1959（2020）19-0147-03
作者:
王 晶
济宁市兖州区人民医院消化内科，山东 济宁 272100
Author(s):
WANG Jing
Department of Gastroenterology,People’s Hospital of Yanzhou District,Jining 272100,Shandong,China
关键词:
肝硬化上消化道出血; 垂体后叶素; 硝酸甘油; 血小板计数; 肝功能
Keywords:
Upper gastrointestinal bleeding with cirrhosis; Pituitrin; Nitroglycerin; Platelet count;  Liver function
分类号:
R575.2；R573.2
DOI:
10.3969/j.issn.1006-1959.2020.19.046
文献标志码:
A
摘要:
目的 观察垂体后叶素与硝酸甘油联合使用对肝硬化上消化道出血患者血小板计数及肝功能的影响。方法 选取2017年11月~2019年10月我院接收的120例肝硬化上消化道出血患者作为研究对象，随机分为对照组和观察组，各60例。对照组应用垂体后叶素治疗，观察组在此治疗基础上加用硝酸甘油，比较两组血小板计数及肝功能[谷丙转氨酶（ALT）、谷草转氨酶（AST）、总胆红素（TBIL）]。结果 治疗72 h后，观察组血小板计数为（117.61±17.25）×109/L，高于对照组的（101.79±15.26）×109/L，ALT、AST、TBIL水平分别为（64.11±8.20）U/L、（61.13±8.31）U/L、（22.46±4.22）μmol/L，均低于对照组的（78.51±10.28）U/L、（70.81±9.20）U/L、（28.71±4.61）μmol/L，差异有统计学意义（P＜0.05）。结论 垂体后叶素联合硝酸甘油可改善肝硬化上消化道出血患者肝功能，提高血小板计数，促进患者恢复。
Abstract:
Objective To observe the effect of combined use of pituitrin and nitroglycerin on platelet count and liver function in patients with upper gastrointestinal bleeding in liver cirrhosis.Methods A total of 120 patients with liver cirrhosis and upper gastrointestinal hemorrhage received in our hospital from November 2017 to October 2019 were selected as the research objects, and they were randomly divided into a control group and an observation group, with 60 cases in each group. The control group was treated with pituitrin, and the observation group was treated with nitroglycerin on the basis of this treatment. The platelet count and liver function of the two groups were compared [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) ].Results After 72 h of treatment, the platelet count of the observation group was (117.61±17.25)×109/L, which was higher than that of the control group (101.79±15.26)×109/L. The levels of ALT, AST and TBIL in the observation group were (64.11±8.20), respectively U/L, (61.13±8.31) U/L, (22.46±4.22) μmol/L, all lower than the control group (78.51±10.28) U/L, (70.81±9.20) U/L, (28.71±4.61) μmol/L, the difference was statistically significant (P<0.05).Conclusion Pituitrin combined with nitroglycerin could improve liver function in patients with upper gastrointestinal bleeding in liver cirrhosis, increase platelet count, and promote the recovery of patients.

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更新日期/Last Update: 1900-01-01