[1]林 磊.血清同型半胱氨酸水平与中青年脑梗死后抑郁的相关性研究[J].医学信息,2021,34(02):127-128.[doi:10.3969/j.issn.1006-1959.2021.02.034]
　LIN Lei.Study on the Relationship Between Serum Homocysteine Level and Depression After Cerebral Infarction in the Young and Middle-aged[J].Medical Information,2021,34(02):127-128.[doi:10.3969/j.issn.1006-1959.2021.02.034]
点击复制

血清同型半胱氨酸水平与中青年脑梗死后抑郁的相关性研究()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年02期
页码:
127-128
栏目:
临床研究
出版日期:
2021-01-15

文章信息/Info

Title:
Study on the Relationship Between Serum Homocysteine Level and Depression After Cerebral Infarction in the Young and Middle-aged
文章编号:
1006-1959（2021）02-0127-02
作者:
林 磊
（新泰市人民医院神经内科，山东 新泰 271200）
Author(s):
LIN Lei
(Department of Neurology,Xintai People’s Hospital,Xintai 271200,Shandong,China)
关键词:
中青年; 脑梗死后抑郁; 同型半胱氨酸
Keywords:
Young and middle-aged; Depression after cerebral infarction; Homocysteine
分类号:
R749.1；R743.33
DOI:
10.3969/j.issn.1006-1959.2021.02.034
文献标志码:
A
摘要:
目的 探究中青年急性脑梗死后抑郁与血清同型半胱氨酸（Hcy）水平的关系。方法 收集我院2018年6月~2020年1月的100例脑梗死后抑郁患者设为脑梗死抑郁组，100例脑梗死后无抑郁患者设为脑梗死无抑郁组，另选同期中青年非脑梗死患者100例为对照组，比较三组间Hcy的水平。据HAMD-17得分将脑梗死后抑郁组患者分为轻度、中度及重度三个亚组，比较三组Hcy的水平。结果 脑梗死后抑郁组Hcy的水平高于脑梗死后无抑郁组、对照组（P＜0.05），且脑梗死后无抑郁组Hcy的水平高于对照组（P＜0.05）；重度抑郁患者Hcy水平高于中度、轻度抑郁患者（P＜0.05），且中度抑郁患者Hcy水平高于轻度抑郁患者（P＜0.05）；相关性分析结果显示HAMD得分与血清Hcy呈正相关性（r=0.458，P＜0.05）。结论 中青年急性脑梗死后抑郁的发生与血清Hcy水平相关，且Hcy水平越高，抑郁程度越重，早期监测Hcy水平并积极给予控制可能有助于有效降低梗死后抑郁的发生发展。
Abstract:
Objective To explore the relationship between depression and serum homocysteine(Hcy) levels after acute cerebral infarction in young people.Methods A total of 100 patients with depression after cerebral infarction in our hospital from June 2018 to January 2020 were selected as the cerebral infarction depression group, and 100 patients without depression after cerebral infarction were selected as the cerebral infarction non-depression group. 100 patients with cerebral infarction served as the control group, and the Hcy levels between the three groups were compared. According to the HAMD-17 score, patients in the post-infarction depression group were divided into three subgroups: mild, moderate and severe, and the levels of Hcy in the three groups were compared.Results The Hcy level of the depression group after cerebral infarction was higher than that of the non-depression group and the control group after cerebral infarction(P＜0.05), and the Hcy level of the non-depression group after cerebral infarction was higher than that of the control group (P＜0.05);The Hcy level of severely depressed patients was higher than that of moderate and mildly depressed patients (P＜0.05), and the Hcy level of moderately depressed patients was higher than that of mildly depressed patients (P＜0.05);The results of correlation analysis showed that the HAMD score was positively correlated with serum Hcy (r=0.458,P＜0.05).Conclusion The occurrence of depression after acute cerebral infarction in the young and middle-aged is related to the serum Hcy level, and the higher the Hcy level, the more severe the depression. Early monitoring of Hcy level and active control may help to effectively reduce the occurrence and development of post-infarction depression.

参考文献/References:

[1]中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2014[J].中华神经科杂志,2015,48(4):246-257. [2]American Psychiatric Association.Diagnostic and statistical manual of mental disorders fifth edition[M].Arlington VA:American Psychiatric Association,2013. [3]刘增雪,陆静珏,周一心.关于卒中后抑郁发病机制的研究新进展[J].中国医药导报,2019,16(2):24-28. [4]Kim H,Kong E,CHeon E,et al.Association between cerebral amyloid deposition and clinical factors including cognitive functionin geriatric depression:pilot study using amyloid positron emission tomography[J].Clin Psychopharmacol Ncurosci,2016,14(4):378-382. [5]Schottkc H,Giabbiconi CM.Post-stroke depression and post-stroke anxiety:prevalence and predictors[J].International Psychogcriatrics,2015.27(11):1805-1812. [6]蔡敏敏.脑梗死后抑郁症多因素临床分析[J].国药物经济学,2014,12(2):412-413. [7]Vojtikiv-Samoilovska D,Arsovska A.Prevalence and Predictors of Depression after Stroke-Results from a Prospective Study[J].Open Access Maced J Med Sci,2018,6(5):824-828. [8]Villa RF,Ferrari F,Moretti A.Post-stroke depression:Mechanisms and pharmacological treatment[J].Pharmacol Ther,2018(184):131-144.

相似文献/References:

[1]陈玉媛,易爱姣,谭齐鸣,等.中青年冠状动脉粥样硬化患者颈动脉硬化的超声特征[J].医学信息,2019,32(02):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
　CHEN Yu-yuan,YI Ai-jiao,TAN Qi-ming,et al.Ultrasound Characteristics of Carotid Atherosclerosis in Young and Middle-aged Patients with Coronary Atherosclerosis[J].Medical Information,2019,32(02):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
[2]朱树花.高尿酸血症与中青年无症状性脑梗死的相关性分析[J].医学信息,2019,32(04):107.[doi:10.3969/j.issn.1006-1959.2019.04.034]
　ZHU Shu-hua.Correlation between Hyperuricemia and Asymptomatic Cerebral Infarction in Young and Middle-aged[J].Medical Information,2019,32(02):107.[doi:10.3969/j.issn.1006-1959.2019.04.034]
[3]刘良红,郑晓佳,陈日秋,等.信息化靶向行为干预模式在初诊中青年糖尿病中的应用效果[J].医学信息,2020,33(14):85.[doi:10.3969/j.issn.1006-1959.2020.14.024]
　LIU Liang-hong,ZHENG Xiao-jia,CHEN Ri-qiu,et al.Application Effect of Information-based Targeted Behavior Intervention Model in Newly Diagnosed Young and Middle-aged Diabetes[J].Medical Information,2020,33(02):85.[doi:10.3969/j.issn.1006-1959.2020.14.024]
[4]毛志伟.中青年冠心病患者觉知压力与智谋的相关性研究[J].医学信息,2021,34(19):142.[doi:10.3969/j.issn.1006-1959.2021.19.038]
　MAO Zhi-wei.Correlation Analysis of Perceived Pressure and Resourcefulness in Young andMiddle-aged Patients with Coronary Heart Disease[J].Medical Information,2021,34(02):142.[doi:10.3969/j.issn.1006-1959.2021.19.038]
[5]吴宗壁,徐明明,应 锰,等.中青年维持性血液透析患者护理服务需求问卷编制及信效度检验[J].医学信息,2022,35(19):26.[doi:10.3969/j.issn.1006-1959.2022.19.007]
　WU Zong-bi,XU Ming-ming,YING Meng,et al.Development and Reliability and Validity Test of Nursing Service Demand Questionnaire for Young and Middle-aged Maintenance Hemodialysis Patients[J].Medical Information,2022,35(02):26.[doi:10.3969/j.issn.1006-1959.2022.19.007]
[6]张亦晗,刘晓戈,喻玲玲,等.中青年经皮冠状动脉介入治疗术后患者配偶照顾者疾病获益感现状及影响因素分析[J].医学信息,2023,36(03):53.[doi:10.3969/j.issn.1006-1959.2023.03.012]
　ZHANG Yi-han,LIU Xiao-ge,YU Ling-ling,et al.Analysis of the Status Quo and Influencing Factors of Perceived Caregiving Benefits of Spouse Caregivers of Young and Middle-aged Patients After Percutaneous Coronary Intervention[J].Medical Information,2023,36(02):53.[doi:10.3969/j.issn.1006-1959.2023.03.012]
[7]赵海峰,王大为.中青年高甘油三酯血症性急性胰腺炎患者临床特征及危险因素分析[J].医学信息,2023,36(03):114.[doi:10.3969/j.issn.1006-1959.2023.03.023]
　ZHAO Hai-feng,WANG Da-wei.Analysis of Clinical Characteristics and Risk Factors in Young and Middle-aged Patients with Hypertriglyceridemia Acute Pancreatitis[J].Medical Information,2023,36(02):114.[doi:10.3969/j.issn.1006-1959.2023.03.023]

更新日期/Last Update: 1900-01-01