[1]邵垭杰,毕小江,孙心悦,等.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的Meta分析[J].医学信息,2021,34(04):119-122,129.[doi:10.3969/j.issn.1006-1959.2021.04.031]
　SHAO Ya-jie,BI Xiao-jiang,SUN Xin-yue,et al.Meta Analysis of Betahistine Combined with Flunarizine Hydrochloride in the Treatment of Tinnitus[J].Medical Information,2021,34(04):119-122,129.[doi:10.3969/j.issn.1006-1959.2021.04.031]
点击复制

倍他司汀联合盐酸氟桂利嗪治疗耳鸣的Meta分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
119-122,129
栏目:
论著
出版日期:
2021-02-15

文章信息/Info

Title:
Meta Analysis of Betahistine Combined with Flunarizine Hydrochloride in the Treatment of Tinnitus
文章编号:
1006-1959（2021）04-0119-05
作者:
邵垭杰; 毕小江; 孙心悦; 等
（延安大学基础医学院/延安市微生物药物创新及转化重点实验室，陕西 延安 716000）
Author(s):
SHAO Ya-jie; BI Xiao-jiang; SUN Xin-yue; et al.
(Yan’an University School of Basic Medicine/Yan’an Key Laboratory of Microbial Drug Innovation and Transformation, Yan’an 716000,Shaanxi,China)
关键词:
倍他司汀; 盐酸氟桂利嗪; 耳鸣
Keywords:
Betahistine; Flunarizine Hydrochloride; Tinnitus
分类号:
R764.45
DOI:
10.3969/j.issn.1006-1959.2021.04.031
文献标志码:
A
摘要:
目的 系统评价倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果。方法 计算机检索PubMed、The Cochrane Library、Clinical Queries、CNKI、WanFang Data、维普数据库中倍他司汀联合盐酸氟桂利嗪治疗耳鸣的文献，以“倍他司汀、盐酸氟桂利嗪、耳鸣、Flunarizine hydrochloride 、Betahistine、Tinnitus”为检索关键词，检索时限从建库至2020年5月。根据设定的纳入与排除标准用NoteExpress筛选合格的文献并采用RevMan5.3软件进行Meta分析。结果 共计纳入9篇文献包括治疗组和对照组人群各417例。倍他司汀联合盐酸氟桂利嗪治疗耳鸣的总有效率高于对照组[OR=5.25，95%CI（2.33，11.82），P＜0.0001]，耳鸣严重程度评分低于对照组[MD=-1.96，95%CI（-2.17，-1.76），P＜0.00001]，听阈水平低于对照组[MD=-5.87， 95%CI（-8.12，-3.63），P＜0.00001]，血浆粘度120比率低于对照组[MD=-0.29，95%CI（-0.41，-0.17），P＜0.00001]，全血粘度低切低于对照组[MD=-2.54，95%CI（-3.58，-1.51），P＜0.00001]。结论 倍他司汀联合盐酸氟桂利嗪治疗耳鸣较单纯使用盐酸氟桂利嗪安全有效，对于早期原因不明的主观性耳鸣患者，可以采用二者联合进行治疗，同时受纳入文献质量与样本量的影响，建议开展更高质量的研究，以进一步佐证倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果。
Abstract:
Objective To systematically evaluate the efficacy of betahistine combined with flunarizine hydrochloride in the treatment of tinnitus.Methods Computer search of PubMed, The Cochrane Library, Clinical Queries, CNKI, WanFang Data, Weipu database for betahistine combined with flunarizine hydrochloride in the treatment of tinnitus literature,using "betahistine, flunarizine hydrochloride, tinnitus, Flunarizine hydrochloride, Betahistine, Tinnitus" as search keywords,the search time limit is from the establishment of the database to May 2020.According to the set inclusion and exclusion criteria, NoteExpress was used to screen qualified documents and RevMan5.3 software was used for Meta analysis.Results A total of 9 references were included， including 417 patients in the treatment group and 417 patients in the control group. Betahistine combined flunarizine hydrochloride in the treatment of tinnitus in the total effective rate was higher than the control group[OR=5.25，95%CI=（2.33，11.82），P＜0.0001]， tinnitus severity score was lower than the control group[MD=-1.96，95%CI=（-2.17，-1.76），P＜0.00001]， auditory threshold level was lower than the control group[MD=-5.87，95%CI=（-8.12，-3.63），P＜0.00001]， Plasma viscosity ratio 120 was lower than the control group[MD=-0.29，95%CI=（-0.41，-0.17），P＜0.00001]， whole blood low shear viscosity was lower than the control group[MD=-2.54，95%CI=（-3.58，-1.51），P＜0.00001]. Conclusion Betahistine combined with flunarizine hydrochloride in the treatment of tinnitus is safer and more effective than flunarizine hydrochloride alone. For patients with subjective tinnitus of unknown early cause， the combination of the two can be used for treatment， and it is also subject to the quality of the included literature and sample size. Therefore， it is recommended to carry out higher quality research to further confirm the effect of betahistine combined with flunarizine hydrochloride in the treatment of tinnitus.

参考文献/References:

[1]Deklerck AN,Marechal C,Pérez Fernández AM,et al.Invasive Neuromodulation as a Treatment for Tinnitus:A Systematic Review[J].Neuromodulation,2020,23(4):451-462. [2]孙永东.浅谈耳鸣的机制与阴阳失衡的关系[J].中医眼耳鼻喉杂志,2018,8(3):168-173. [3]母晓松,蒲晓兵,刘一瑾,等.耳鸣治疗的国内外研究进展[J].四川医学,2020,41(1):16-19. [4]董怡君,赵宇,任建君.《欧洲耳鸣多学科指南:诊断、评估和治疗》解读[J].四川医学,2020,41(1):6-9. [5]Jadad AR,Moore RA,Carroll D,et al.Assessing the quality of reports of randomized clinical trials:is blinding necessary[J].Controlled Clinical Trials,1996,17(1):1-12. [6]熊向菁,王青海,付海生,等.甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果及安全性分析[J].药物评价研究,2019,42(1):145-148. [7]杨凌鹏,卢辛辛.倍他司汀与盐酸氟桂利嗪联用对耳鸣患者症状改善的疗效评价[J].抗感染学,2018,15(7):1233-1235. [8]罗霓.甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的临床应用分析[J].中国处方药2018,16(3):90-91. [9]杨少峰,龚继涛.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的疗效及安全性探讨[J].中国听力语言康复科学杂志,2017,15(5):365-367. [10]李宏斌.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的随机双盲对照初步研究[J].中国现代药物应用,2017,11(22):109-110. [11]魏金龙,赵志明,杨艳,等.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的疗效研究[J].中外医疗,2015,34(14):108-109. [12]叶晓英.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的效果观察[J].中国耳鼻咽喉颅底外科杂志,2013,19(6):524-526. [13]高士杰.甲磺酸倍他司汀联合盐酸氟桂利嗪治疗耳鸣的临床研究[J].中国现代药物应用,2012,6(5):76-77. [14]马芙蓉,辛颖,赵一鸣,等.倍他司汀联合盐酸氟桂利嗪治疗耳鸣的随机双盲对照初步研究[J].中华耳鼻咽喉头颈外科杂志,2006,41(4):269-273. [15]于澜,王秋菊.耳鸣相关基因研究进展[J].中华耳科学杂志,2020,18(4):763-767. [16]鲁文琴,尹航.盐酸氟桂利嗪胶囊的临床研究与药理作用[J].中国现代药物应用,2012,6(19):130-131. [17]丁晓云,古辉,罗建平,等.倍他司汀治疗眩晕80例疗效观察[J].现代诊断与治疗,2013,24(15):3433-3434. [18]Gananca MM,Caovilla HH,Gazzola JM,et al.Betahistine in the treatment of tinnitus in patients with vestibular disorders[J].Braz J Otorhinolaryngol,2011,77(4):499-503. [19]王洪田,李明,刘蓬,等.耳鸣的诊断和治疗指南(建议案)[J].中华耳科学杂志,2009,7(3):185. [20]贺璐,王国鹏,彭哲,等.耳鸣临床应用指南[J].听力学及言语疾病杂志,2015,23(2):116-139.

相似文献/References:

[1]彭莹萍.尼莫地平与盐酸氟桂利嗪治疗老年偏头痛的临床疗效观察[J].医学信息,2018,31(22):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]
　PENG Ying-ping.Clinical Efficacy of Nimodipine and Flunarizine Hydrochloride in the Treatment of Senile Migraine[J].Medical Information,2018,31(04):150.[doi:10.3969/j.issn.1006-1959.2018.22.044]
[2]韩 晋,陈淑媛,董瑞宾,等.神经生长因子与盐酸氟桂利嗪联合治疗高血压脑出血的疗效[J].医学信息,2019,32(21):81.[doi:10.3969/j.issn.1006-1959.2019.21.025]
　HAN Jin,CHEN Shu-yuan,DONG Rui-bin,et al.Effect of Nerve Growth Factor Combined with Flunarizine Hydrochloride on Hypertensive Intracerebral Hemorrhage[J].Medical Information,2019,32(04):81.[doi:10.3969/j.issn.1006-1959.2019.21.025]
[3]李书华.倍他司汀治疗原发性HC-BPPV患者复位后残余头晕的效果[J].医学信息,2022,35(01):158.[doi:10.3969/j.issn.1006-1959.2022.01.039]
　LI Shu-hua.Effect of Betahistine on Residual Dizziness After Reduction in Patients with Primary HC-BPPV[J].Medical Information,2022,35(04):158.[doi:10.3969/j.issn.1006-1959.2022.01.039]
[4]吴达文,郭雪平,谢丽媛.天麻钩藤饮加减治疗肝阳上亢型后循环缺血性眩晕的效果[J].医学信息,2022,35(17):148.[doi:10.3969/j.issn.1006-1959.2022.17.041]
　WU Da-wen,GUO Xue-ping,XIE Li-yuan.Effect of Tianma Gouteng Decoction in the treatment of Posterior Circulation Ischemic Vertigo of Liver-yang Hyperactivity Type[J].Medical Information,2022,35(04):148.[doi:10.3969/j.issn.1006-1959.2022.17.041]
[5]何颖颖,陈雪生,沈崇岭.倍他司汀联合Epley手法复位对耳石症患者眩晕障碍及前庭症状的影响[J].医学信息,2023,36(13):127.[doi:10.3969/j.issn.1006-1959.2023.13.026]
　HE Ying-ying,CHEN Xue-sheng,SHEN Chong-ling.Effect of Betahistine Combined with Epley Manual Reduction on Vertigo Disorder and Vestibular Symptoms in Patients with Otolith[J].Medical Information,2023,36(04):127.[doi:10.3969/j.issn.1006-1959.2023.13.026]

更新日期/Last Update: 1900-01-01