[1]鄢志辉,孙 立,简月奎.结核IgG抗体检测、T-SPOT及痰结核分枝杆菌核酸检测对骨关节结核的诊断价值[J].医学信息,2021,34(07):85-87.[doi:10.3969/j.issn.1006-1959.2021.07.023]
　YAN Zhi-hui,SUN Li,JIAN Yue-kui.The Diagnostic Value of Tuberculosis IgG Antibody Detection,T-SPOT and Sputum Mycobacterium Tuberculosis Nucleic Acid Detection for Osteoarticular Tuberculosis[J].Medical Information,2021,34(07):85-87.[doi:10.3969/j.issn.1006-1959.2021.07.023]
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结核IgG抗体检测、T-SPOT及痰结核分枝杆菌核酸检测对骨关节结核的诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年07期
页码:
85-87
栏目:
论著
出版日期:
2021-04-01

文章信息/Info

Title:
The Diagnostic Value of Tuberculosis IgG Antibody Detection,T-SPOT and Sputum Mycobacterium Tuberculosis Nucleic Acid Detection for Osteoarticular Tuberculosis
文章编号:
1006-1959（2021）07-0085-03
作者:
鄢志辉; 孙 立; 简月奎
（贵州省人民医院骨科，贵州 贵阳 550002）
Author(s):
YAN Zhi-hui; SUN Li; JIAN Yue-kui
(Department of Orthopedics,Guizhou Provincial People’s Hospital,Guiyang 550002,Guizhou,China)
关键词:
骨关节结核; T-SPOT; TB-DNA; IgG抗体
Keywords:
Osteoarticular tuberculosis; T-SPOT; TB-DNA; IgG antibody
分类号:
R529.2
DOI:
10.3969/j.issn.1006-1959.2021.07.023
文献标志码:
A
摘要:
目的 探讨结核分枝杆菌IgG抗体（IgG抗体）检测、结核感染T淋巴细胞斑点试验（T-SPOT）及痰结核分枝杆菌核酸PCR检测（TB-DNA）对诊断骨关节结核的临床价值。方法 回顾性分析2017年1月~2018年10月在我科确诊为骨关节结核患者，共196例，另选取同时期非结核患者作为对照组，共69例。所有患者都采用血清结核IgG抗体、外周血T-SPOT及痰TB-DNA三种检测技术。比较三种检测技术的敏感性和特异性，评估临床价值。结果 在196例骨关节结核患者中，三种检测技术敏感性T-SPOT＞结核IgG抗体＞痰TB-DNA，差异有统计学意义（P＜0.05）；在69例非结核患者中，三种检测技术特异性痰TB-DNA＞结核IgG抗体＞T-SPOT，差异有统计学意义（P＜0.05）。结论 三种检测技术的敏感性和特异性存在差异，其中T-SPOT检测敏感性最高，痰TB-DNA特异性最高，快速诊断骨关节结核还需结合多种检测技术。
Abstract:
Objective To explore the clinical value of Mycobacterium tuberculosis IgG antibody (IgG antibody) detection, tuberculosis infection T lymphocyte spot test (T-SPOT) and sputum Mycobacterium tuberculosis nucleic acid PCR detection (TB-DNA) in the diagnosis of osteoarticular tuberculosis.Methods A retrospective analysis of 196 cases of osteoarticular tuberculosis diagnosed in our department from January 2017 to October 2018 was performed. In addition, non-tuberculous patients of the same period were selected as the control group, a total of 69 cases.All patients used three detection techniques: serum tuberculosis IgG antibody, peripheral blood T-SPOT and sputum TB-DNA.Compare the sensitivity and specificity of the three detection techniques and evaluate the clinical value.Results Among the 196 cases of osteoarticular tuberculosis, the sensitivity of the three detection techniques: T-SPOT＞TB IgG antibody＞sputum TB-DNA, the difference was statistically significant (P＜0.05);Among 69 non-tuberculosis patients, the three detection techniques specific sputum TB-DNA＞TB IgG antibody＞T-SPOT, the difference was statistically significant (P＜0.05).Conclusion There are differences in the sensitivity and specificity of the three detection technologies.T-SPOT has the highest sensitivity and sputum TB-DNA has the highest specificity. The rapid diagnosis of osteoarticular tuberculosis requires a combination of multiple detection technologies.

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更新日期/Last Update: 1900-01-01