[1]李岩华.宫腔镜电切术联合孕激素治疗早期孕激素受体阳性子宫内膜癌的疗效[J].医学信息,2021,34(14):133-135.[doi:10.3969/j.issn.1006-1959.2021.14.036]
　LI Yan-hua.Efficacy of Hysteroscopic Resection Combined with Progesterone in the Treatment of Early Progesterone Receptor-positive Endometrial Carcinoma[J].Medical Information,2021,34(14):133-135.[doi:10.3969/j.issn.1006-1959.2021.14.036]
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宫腔镜电切术联合孕激素治疗早期孕激素受体阳性子宫内膜癌的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
133-135
栏目:
临床研究
出版日期:
2021-07-15

文章信息/Info

Title:
Efficacy of Hysteroscopic Resection Combined with Progesterone in the Treatment of Early Progesterone Receptor-positive Endometrial Carcinoma
文章编号:
1006-1959（2021）14-0133-03
作者:
李岩华
（天津市东丽区东丽医院妇科，天津 300300）
Author(s):
LI Yan-hua
(Department of Gynecology,Dongli Hospital,Dongli District,Tianjin 300300,China)
关键词:
宫腔镜电切术; 孕激素; 子宫内膜癌
Keywords:
Hysteroscopic resection; Progesterone; Endometrial carcinoma
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2021.14.036
文献标志码:
A
摘要:
目的 研究宫腔镜电切术联合孕激素治疗早期孕激素受体阳性子宫内膜癌的疗效。方法 选取2018年1月~2020年1月我院诊治的60例早期孕激素受体阳性子宫内膜癌患者为研究对象，采用随机数字表法分为对照组和观察组，各30例。对照组采用宫腔镜电切术治疗，观察组在对照组基础上给予孕激素治疗，比较两组治疗总有效率、复发率、初诊至复发平均时间雌激素受体（ER）和孕激素受体（PR）阳性率、血清指标[CA125抗原、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）]水平以及不良反应发生率。结果 观察组治疗总有效率为93.33%，高于对照组的80.00%，差异有统计学意义（P＜0.05）；随访6个月，观察组复发率为6.67%，低于对照组的16.67%，差异有统计学意义（P＜0.05）；观察组初诊至复发平均时间长于对照组，ER、PR阳性率均高于对照组，差异有统计学意义（P＜0.05）；治疗后，两组CA125、TNF-α、IL-6均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）；在治疗和观察期间，观察组不良反应发生率为10.00%，与对照组的6.67%比较，差异无统计学意义（P＞0.05）。结论 宫腔镜电切术联合孕激素治疗早期孕激素受体阳性子宫内膜癌可提高治疗总有效率，降低复发率，提高雌孕激素受体阳性率，降低CA125、TNF-α、IL-6水平，且不增加不良反应发生几率，应用安全有效。
Abstract:
Objective To study the curative effect of hysteroscopic resection combined with progesterone in the treatment of early progesterone receptor-positive endometrial cancer.Methods A total of 60 patients with early progesterone receptor-positive endometrial cancer diagnosed and treated in our hospital from January 2018 to January 2020 were selected as the research objects. They were divided into a control group and an observation group by random number table method, with 30 cases in each group.The control group was treated with hysteroscopic resection, and the observation group was treated with progesterone on the basis of the control group.The total effective rate, recurrence rate, mean time from first diagnosis to recurrence, positive rate of estrogen receptor (ER) and progesterone receptor (PR), serum indicators [CA125 antigen, tumor necrosis factor-α (TNF-α)] were compared between the two groups,Interleukin-6 (IL-6)] levels and the incidence of adverse reactions.Results The total effective rate of treatment in the observation group was 93.33%, which was higher than 80.00% in the control group,the difference was statistically significant(P<0.05);After 6 months of follow-up, the recurrence rate of the observation group was 6.67%, which was lower than the 16.67% of the control group,the difference was statistically significant (P<0.05);The average time from first diagnosis to recurrence in the observation group was longer than that in the control group, and the positive rates of ER and PR were higher than those in the control group, the difference was statistically significant (P<0.05);After treatment, the levels of CA125, TNF-α, and IL-6 in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant(P<0.05);During the treatment and observation period, the incidence of adverse reactions in the observation group was 10.00%, compared with 6.67% in the control group, the difference was not statistically significant(P>0.05).Conclusion Hysteroscopic resection combined with progesterone in the treatment of early progesterone receptor-positive endometrial cancer can increase the total effective rate of treatment, reduce the recurrence rate, increase the positive rate of estrogen and progesterone receptors, and reduce CA125, TNF-α, and IL- 6 level, and does not increase the probability of adverse reactions, the application is safe and effective.

参考文献/References:

[1]徐珍,彭芝兰,曾俐琴,等.358例子宫内膜癌手术方式及影响预后的危险因素分析[J].实用妇产科杂志,2015,31(4):274-277. [2]Chu LH,Chang WC,Sheu BC.Comparison of the laparoscopic versus conventional open method for surgical staging of endometrial carcinoma[J].Taiwan J Obstet Gynecol,2016,55(2):188-192. [3]周蓉,鹿群,刘国莉,等.早期子宫内膜癌保留生育功能治疗专家共识[J].中国妇产科临床杂志,2019,20(4):369-373. [4]李增军.宫腔镜电切术联合激素治疗早期子宫内膜癌的效果及对患者生育功能的影响[J].河南医学研究,2017,26(15):2811-2812. [5]王国艳.宫腔镜电切术联合孕激素治疗早期子宫内膜癌的疗效分析[J].中国医药指南,2017,15(3):74-75. [6]王维,孙静,邹建话,等.子宫内膜癌患者BMI、胰岛素抵抗、炎性因子的检测及对预后的影响[J].海南医学院学报,2015,21(7):954-956,960. [7]张学术,曹文芳,杨慧.45岁以下子宫内膜癌患者术后3年生存影响因素分析[J].现代肿瘤医学,2016,24(3):445-448. [8]邢洁,谢幸,于爱军,等.早期年轻子宫内膜癌患者孕激素治疗的疗效及安全性分析[J].中国癌症杂志,2014,24(12):931-935. [9]窦磊,郭科军.腹腔镜手术在早期子宫内膜癌治疗中的疗效观察[J].中国医科大学学报,2016,45(3):241-245. [10]Yin X,Shi M,Xu J,et al.Perioperative and long-term outcomes of laparoscopy and laparotomy for endometrial carcinoma[J].Int J Clin Exp Med,2015,8(10):19093-19099. [11]周云霞,覃文雄,张洁清,等.孕激素辅助治疗术后高危型子宫内膜癌的临床病理分析[J].广西医科大学学报,2015,32(1):93-95. [12]周勤英.宫腔镜电切术联合孕激素对早期子宫内膜癌患者生育功能的影响[J].长治医学院学报,2016,30(6):455-457. [13]丁堪铄,卢丽娜,余莉萍,等.C-erbB-2、p53、Ki-67、ER、PR在子宫内膜癌中的表达及临床相关性[J].实用医学杂志,2015,31(24):4069-4071. [14]商庆花,赵岭岭,刘俊芳,等.C-erB-2、ER、PR在子宫内膜癌中的表达及意义[J].贵州医药,2016,40(4):362-364. [15]罗敏.宫腔镜电切术联合孕激素治疗早期子宫内膜癌患者5例临床分析[J].齐齐哈尔医学院学报,2015,36(13):1902-1903.

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更新日期/Last Update: 1900-01-01