[1]王 伟.不同洗脱支架对冠心病合并糖尿病患者IGF-1及IGF-1R表达的影响[J].医学信息,2021,34(15):102-104.[doi:10.3969/j.issn.1006-1959.2021.15.026]
　WANG Wei.Effects of Different Eluting Stents on the Expression of IGF-1 and IGF-1R in Patients with Coronary Heart Disease and Diabetes[J].Medical Information,2021,34(15):102-104.[doi:10.3969/j.issn.1006-1959.2021.15.026]
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不同洗脱支架对冠心病合并糖尿病患者IGF-1及IGF-1R表达的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年15期
页码:
102-104
栏目:
论著
出版日期:
2021-08-01

文章信息/Info

Title:
Effects of Different Eluting Stents on the Expression of IGF-1 and IGF-1R in Patients with Coronary Heart Disease and Diabetes
文章编号:
1006-1959（2021）15-0102-03
作者:
王 伟
（佳木斯市中心医院心内科，黑龙江 佳木斯 154002）
Author(s):
WANG Wei
(Department of Cardiology,the Central Hospital of Jiamusi City,Jiamusi 154002,Heilongjiang,China)
关键词:
依维莫司; 雷帕霉素; 冠心病; 糖尿病; 洗脱支架
Keywords:
Everolimus; Rapamycin; Coronary heart disease; Diabetes; Eluting stent
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2021.15.026
文献标志码:
A
摘要:
目的 探讨不同洗脱支架对冠心病合并糖尿病患者胰岛素样生长因子1（IGF-1）及胰岛素样生长因子1受体（IGF-1R）表达的影响。方法 选择2018年2月~2020年2月我院诊治的冠心病合并糖尿病患者110例作为研究对象，根据随机数字表法分为观察组与对照组，各55例。两组均给予经皮冠状动脉介入（PCI）治疗，对照组与观察组分别采用雷帕霉素药物洗脱支架与依维莫司药物洗脱支架植入，比较两组治疗疗效、术前与术后即刻靶血管最小管腔直径与管腔狭窄程度、IGF-1与IGF-1R表达情况及随访主要不良心血管事件发生情况。结果 观察组术后1个月治疗总有效率为98.18%，高于对照组的87.27%，差异有统计学意义（P＜0.05）；两组靶血管最小管腔直径与管腔狭窄程度比较，差异有统计学意义（P＜0.05）；观察组IGF-1、IGF-1R水平高于对照组，差异有统计学意义（P＜0.05）；观察组术后6个月主要不良心血管事件发生率为7.27%，低于对照组的23.64%，差异有统计学意义（P＜0.05）。结论 相对于雷帕霉素药物洗脱支架，依维莫司药物洗脱支架在冠心病合并糖尿病患者中的应用能促进血清IGF-1、IGF-1R的释放，改善靶血管状态，提高治疗效果，减少随访主要不良心血管事件发生几率。
Abstract:
Objective To investigate the effect of different eluting stents on the expression of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 1 receptor (IGF-1R) in patients with coronary heart disease and diabetes.Methods A total of 110 patients with coronary heart disease and diabetes mellitus diagnosed and treated in our hospital from February 2018 to February 2020 were selected as the research objects. According to the random number table method, they were divided into observation group and control group, with 55 cases in each group.Both groups were treated with percutaneous coronary intervention (PCI). The control group and the observation group were implanted with rapamycin drug-eluting stents and everolimus drug-eluting stents, respectively.The therapeutic effect, the minimum lumen diameter and the degree of lumen stenosis of the target vessel before and immediately after the operation, the expression of IGF-1 and IGF-1R, and the occurrence of major adverse cardiovascular events were compared between the two groups.Results The total effective rate of treatment in the observation group one month after operation was 98.18%, which was higher than 87.27% in the control group,the difference was statistically significant(P<0.05);There was a statistically significant difference between the minimum lumen diameter of the target vessel and the degree of lumen stenosis between the two groups (P＜0.05);The levels of IGF-1 and IGF-1R in the observation group were higher than those in the control group,the difference was statistically significant (P＜0.05);The incidence of major adverse cardiovascular events in the observation group at 6 months after surgery was 7.27%, which was lower than 23.64% in the control group,the difference was statistically significant(P<0.05).Conclusion Compared with rapamycin drug-eluting stents,the application of everolimus drug-eluting stent in patients with coronary heart disease and diabetes can promote the release of serum IGF-1 and IGF-1R, improve the state of target blood vessels, improve the treatment effect, and reduce the chance of major adverse cardiovascular events during follow-up.

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更新日期/Last Update: 1900-01-01