[1]张 晴,杨勇莉.p16在宫颈癌发生发展中的作用[J].医学信息,2022,35(01):59-61.[doi:10.3969/j.issn.1006-1959.2022.01.014]
　ZHANG Qing,YANG Yong-li.Role of p16 in the Development of Cervical Cancer[J].Medical Information,2022,35(01):59-61.[doi:10.3969/j.issn.1006-1959.2022.01.014]
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p16在宫颈癌发生发展中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年01期
页码:
59-61
栏目:
综述
出版日期:
2022-01-01

文章信息/Info

Title:
Role of p16 in the Development of Cervical Cancer
文章编号:
1006-1959（2022）01-0059-03
作者:
张 晴; 杨勇莉
（1.青海大学研究生院，青海 西宁 810000；2.青海大学附属医院妇科，青海 西宁 810000）
Author(s):
ZHANG Qing; YANG Yong-li
(1.Graduate School of Qinghai University,Xining 810000,Qinghai,China;2.Department of Gynecology,Affiliated Hospital of Qinghai University,Xining 810000,Qinghai,China)
关键词:
宫颈癌; p16; 人乳头瘤病毒; 宫颈上皮内病变
Keywords:
Cervical cancer; p16; Human papillomavirus; Cervical intraepithelial neoplasia
分类号:
R737.33
DOI:
10.3969/j.issn.1006-1959.2022.01.014
文献标志码:
A
摘要:
宫颈癌是临床常见的妇科恶性肿瘤，与高危型人乳头瘤病毒的持续感染相关，严重威胁女性生命健康。早期诊断、治疗对改善宫颈癌患者预后尤为重要。目前大量研究发现，分子水平、多种癌基因、抑癌基因的表达和调控对宫颈癌有着促进作用，其中p16与宫颈癌前病变密切相关，且p16作为宫颈上皮内瘤变2级（CINⅡ）的分类指标，对CINⅡ患者进行分流管理和预后判断具有重要临床意义。本文就p16在细胞周期调控中的作用机制及其在宫颈癌发生发展中的作用作一综述，旨在为临床上早期诊断该病提供参考依据，为改善宫颈癌患者预后以及生存率提供理论支撑。
Abstract:
Cervical cancer is a common gynecological malignant tumor, which is associated with the persistent infection of high-risk human papillomavirus and seriously threatens women ’ s life and health. Early diagnosis and treatment are particularly important for improving the prognosis of patients with cervical cancer. At present, a large number of studies have found that the expression and regulation of molecular level, a variety of oncogenes and tumor suppressor genes have a promoting effect on cervical cancer. Among them, p16 is closely related to cervical precancerous lesions. As a classification index of cervical intraepithelial neoplasia grade 2 (CINⅡ), p16 has clinical significance for triage management and prognosis judgment of CINⅡpatients. This article reviews the mechanism of p16 in cell cycle regulation and its role in the development of cervical cancer, aiming to provide reference for early clinical diagnosis of the disease and provide theoretical support for improving the prognosis and survival rate of patients with cervical cancer.

参考文献/References:

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更新日期/Last Update: 1900-01-01