[1]魏 威,梁凯轶,余艳芳,等.血嗜酸性粒细胞在肺结节良恶性判断中的价值[J].医学信息,2022,35(03):99-102.[doi:10.3969/j.issn.1006-1959.2022.03.023]
　WEI Wei,LIANG Kai-yi,YU Yan-fang,et al.Value of Blood Eosinophils in the Diagnosis of Benign and Malignant Pulmonary Nodules[J].Medical Information,2022,35(03):99-102.[doi:10.3969/j.issn.1006-1959.2022.03.023]
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血嗜酸性粒细胞在肺结节良恶性判断中的价值()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年03期
页码:
99-102
栏目:
论著
出版日期:
2022-02-01

文章信息/Info

Title:
Value of Blood Eosinophils in the Diagnosis of Benign and Malignant Pulmonary Nodules
文章编号:
1006-1959（2022）03-0099-04
作者:
魏 威1; 梁凯轶2; 余艳芳1; 屠春林1; 赵开顺1; 周 慧2
上海健康医学院附属嘉定区中心医院呼吸与危重症医学科1，放射科2，上海 201800
Author(s):
WEI Wei1; LIANG Kai-yi2; YU Yan-fang1; TU Chun-lin1; ZHAO Kai-shun1; ZHOU Hui2
Department of Respiratory Medicine1，Department of Radiology2,Jiading District Central Hospital Affiliated Shanghai Universityof Medicine & Health Sciences,Shanghai 201800,China
关键词:
肺结节; 血嗜酸性粒细胞; 良恶性诊断
Keywords:
Pulmonary nodules; Blood eosinophils; Benign and malignant diagnosis
分类号:
R816.4
DOI:
10.3969/j.issn.1006-1959.2022.03.023
文献标志码:
A
摘要:
目的 探讨血嗜酸性粒细胞对肺结节良恶性鉴别的诊断价值。方法 选择2017年1月-2019年12月在我院行胸部CT提示为肺结节，并经穿刺活检明确病理诊断的患者72例为研究对象；依据病理诊断分为恶性组43例，非恶性组29例，收集两组患者的临床资料并比较，包括年龄、血白细胞、血小板、血中性粒细胞、血淋巴细胞、血单核细胞、血白蛋白、血嗜酸性粒细胞、血嗜碱性粒细胞、血NLR、血总胆红素、血CEA、血CYFRA211、NSE、SCC-Ag，对恶性肺结节的危险因素进行单因素和多因素Logistic回归分析。结果 两组血小板、血嗜酸性粒细胞、血CEA、血CYFRA211、血NSE比较，差异有统计学意义（P＜0.05）；两组年龄、血白细胞、中性粒细胞、淋巴细胞、单核细胞、血清白蛋白、血NLR、血总胆红素、SCC-Ag比较，差异无统计学意义（P＞0.05）；多因素Logistic回归分析表明，血嗜酸性粒细胞是恶性肺结节的独立危险因素。结论 血嗜酸性粒细胞表达水平升高是诊断恶性肺结节的独立危险因素，对判断肺部结节的良恶性有重要的价值。
Abstract:
Objective To investigate the value of blood eosinophils in the diagnosis of benign and malignant pulmonary nodules.Methods From January 2017 to December 2019, 72 patients with pulmonary nodules diagnosed by chest CT and confirmed by biopsy were selected as subjects. According to the pathological diagnosis, the patients were divided into malignant group (43 cases) and non-malignant group (29 cases). The clinical data of the two groups were collected and compared, including age, white blood cells, platelets, blood neutrophils, blood lymphocytes, blood monocytes, serum albumin, blood eosinophils, blood basophils, blood NLR, blood total bilirubin, blood CEA, blood CYFRA211, NSE and SCC-Ag. The risk factors of malignant pulmonary nodules were analyzed by univariate and multivariate Logistic regression analysis.Results The differences in platelet, blood eosinophils, serum CEA, serum CYFRA211 and serum NSE between the two groups were statistically significant (P<0.05). There was no significant difference in age, white blood cells, neutrophils, lymphocytes, monocytes, serum albumin, blood NLR, total bilirubin and SCC-Ag between the two groups (P>0.05). Multivariate Logistic regression analysis showed that blood eosinophils were independent risk factors for malignant pulmonary nodules.Conclusion Elevated blood eosinophil expression is an independent risk factor for the diagnosis of malignant pulmonary nodules, which has important value in judging benign and malignant pulmonary nodules.

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更新日期/Last Update: 1900-01-01