[1]陈 斐,吴开奇.卵巢子宫内膜异位症患者血清抗苗勒氏管激素水平的变化及其价值探讨[J].医学信息,2022,35(07):145-147.[doi:10.3969/j.issn.1006-1959.2022.07.037]
 CHEN Fei,WU Kai-qi.The Change and Value of Serum Anti-Müllerian Hormone Levels in Patients with Ovarian Endometriosis[J].Medical Information,2022,35(07):145-147.[doi:10.3969/j.issn.1006-1959.2022.07.037]
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卵巢子宫内膜异位症患者血清抗苗勒氏管激素水平的变化及其价值探讨()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年07期
页码:
145-147
栏目:
临床研究
出版日期:
2022-04-01

文章信息/Info

Title:
The Change and Value of Serum Anti-Müllerian Hormone Levels in Patients with Ovarian Endometriosis
文章编号:
1006-1959(2022)07-0145-03
作者:
陈 斐吴开奇
(浙江大学医学院附属妇产科医院检验科,浙江 杭州 310006)
Author(s):
CHEN FeiWU Kai-qi
(Department of Clinical Laboratory,Women’s Hopital,School of Medicine,Zhejiang University,Hangzhou 310006,Zhejiang,China)
关键词:
卵巢子宫内膜异位症抗苗勒氏管激素卵巢储备功能子宫内膜异位症囊肿
Keywords:
Ovarian endometriosisAnti-müllerian hormoneOvarian reserve functionOvarian endometrioma
分类号:
R711.75
DOI:
10.3969/j.issn.1006-1959.2022.07.037
文献标志码:
A
摘要:
目的 探讨卵巢子宫内膜异位症(EMS)患者血清抗苗勒氏管激素(AMH)水平变化及手术对卵巢储备功能的影响。方法 选择2019年1月-12月在浙江大学医学院附属妇产科医院收治并确诊的卵巢子宫内膜异位症患者422例,均行腹腔镜下子宫内膜异位症囊肿摘除手术,设为EMS组;根据卵巢受累情况分单侧和双侧EMS。另选取同期232例健康女性设为对照组。采用电化学发光法检测两组血清AMH水平,比较EMS组手术前后、EMS组卵巢不同受累情况、不同临床分期及对照组血清AMH水平。结果 EMS组双侧血清AMH水平低于单侧和对照组(P<0.05);EMS组双侧Ⅲ~Ⅳ期血清AMH水平较Ⅰ~Ⅱ期和对照组低,差异有统计学意义(P<0.05);EMS组术后AMH水平较术前下降(P<0.05)。结论 双侧卵巢子宫内膜异位症会降低患者的卵巢储备功能,临床分期级别较高(Ⅲ~Ⅳ期)相较于低级别(Ⅰ~Ⅱ期)对卵巢储备功能影响较大,腹腔镜下子宫内膜异位症囊肿摘除术短期内可能对卵巢储备功能有影响。
Abstract:
Objective To investigate the changes of serum anti-müllerian hormone (AMH) levels in patients with ovarian endometriosis (EMS) and the impact of surgery on ovarian reserve function.Methods A total of 422 patients with ovarian endometriosis who were diagnosed in Women’s Hospital,School of Medicine,Zhejiang University from January 2019 to December 2019 were selected as EMS group, and all patients underwent laparoscopic endometriosis cystectomy. According to the ovarian involvement, they were divided into unilateral and bilateral EMS. Another 232 healthy women were selected as control group at the same time. The serum AMH levels of the two groups were detected by electrochemiluminescence method. Serum AMH levels were compared before and after operation in EMS group, different ovarian involvement, different clinical stages and control group.Results The serum AMH level of patients with bilateral EMS was significantly lower than that of patients with unilateral EMS and control group (P<0.05). The serum AMH level of patients with bilateral Ⅲ-Ⅳ EMS was lower than that of patients with Ⅰ-Ⅱ EMS and control group (P<0.05). In addition, the level of AMH in EMS patients decreased significantly after operation (P<0.05).Conclusion Bilateral ovarian endometriosis can reduce the ovarian reserve function of patients. Higher clinical stage (stage Ⅲ-Ⅳ) has a greater impact on ovarian reserve function than lower clinical stage (stage Ⅰ-Ⅱ). Laparoscopic endometriosis cystectomy has an impact on ovarian reserve function.

参考文献/References:

[1]杜娟.亮丙瑞林治疗子宫内膜异位症伴不孕的应用[J].医学信息,2020,33(13):43-45.[2]Agarwal SK,Chapron C,Giudice LC,et al.Clinical diagnosis of endometriosis: a call to action[J].Am J Obstet Gynecol,2019,220(4):354.[3]徐晓航,陈圆辉,张翠莲.盆腔子宫内膜异位症合并不孕患者腹腔镜术后体外受精-胚胎移植妊娠结局影响因素[J].中华生殖与避孕杂志,2019,39(4):274-278.[4]Garcia-Ibanez P,Yepes-Molina L,Ruiz-Alcaraz AJ,et al.Brassica Bioactives Could Ameliorate the Chronic Inflammatory Condition of Endometriosis[J].Int J Mol Sci,2020,21(24):9397.[5]Zondervan KT,Becker CM,Koga K,et al.Endometriosis[J].Nat Rev Dis Primers,2018,4(1):9.[6]Anastasiu CV,Moga MA,Elena Neculau A,et al.Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives[J].Int J Mol Sci,2020,21(5):1750.[7]Moga MA,Balan A,Dimienescu OG,et al.Circulating miRNAs as Biomarkers for Endometriosis and Endometriosis-Related Ovarian CancerAn Overview[J].J Clin Med,2019,8(5):735.[8]单江静,郑媛媛,卢琪芸,等.腹腔镜子宫内膜异位症卵巢囊肿剥除术中不同止血方法对卵巢功能影响[J].中华内分泌外科杂志,2016,10(2):170-173,177.[9]Foti PV,Farina R,Palmucci S,et al.Endometriosis: clinical features, MR imaging findings and pathologic correlation[J].Insights Imaging,2018,9(2):149-172.[10]Donnez J,Garcia-Solares J,Dolmans MM.Ovarian endometriosis and fertility preservation: a challenge in 2018[J].Minerva Ginecol,2018,70(4):408-414.[11]郑建波,李艳,夏尊恩.联合检测抗苗勒管激素和性激素对卵巢储备功能评估的临床价值[J].分子诊断与治疗杂志,2018,10(6):400-405.[12]Steiner AZ.Biomarkers of Ovarian Reserve as Predictors of Reproductive Potential[J].Semin Reprod Med,2013,31(6):437-442.[13]Practice Committee of The American Society for Reproductive,Medicine.Endometriosis and infertility:a committee opinion[J].Fertil Steril,2012,98(3):591-598. [14]Moolhuijsen LME,Visser JA.Anti-Mullerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function[J].J Clin Endocr Metab,2020,105(11):3361-3373.[15]何雪梅,李萍,卢晓娴,等.基础FSH/LH比值评估年轻女性卵巢功能的价值[J].中国妇幼保健,2018,33(24):5902-5904.[16]Ozzola G.Anti-Mullerian hormone: A brief review of the literature[J].Clin Ter,2017,168(1):14-22.[17]Shrikhande L,Shrikhand B,Shrikhande A.AMH and Its Clinical Implications[J].J Obstet Gyn India,2020,70(5):337-341.[18]Oh SR,Choe SY,Cho YJ.Clinical application of serum anti-Mullerian hormone in women[J].Clin Exp Reprod Med,2019,46(2):50-59.[19]Dewailly D,Laven J.AMH as the primary marker for fertility[J].Eur J Endocrinol,2019,181(6):D45-D51.[20]张芳,罗军,唐密.腹腔镜卵巢子宫内膜异位囊肿剔除手术对卵巢储备功能影响的研究[J].中国医师杂志,2015,17(5):732-734.[21]Hernandez-Valencia M,Zarate A.Endometriosis.Pathophysiological background for treatment[J].Rev Med Inst Mex Seguro Soc,2009,47(1):57-60.

更新日期/Last Update: 1900-01-01