[1]郭月欢,甘惠中.幽门螺旋杆菌感染与非酒精性脂肪肝的相关性研究[J].医学信息,2022,35(08):89-92.[doi:10.3969/j.issn.1006-1959.2022.08.021]
　GUO Yue-huan,GAN Hui-zhong.Correlation Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease[J].Medical Information,2022,35(08):89-92.[doi:10.3969/j.issn.1006-1959.2022.08.021]
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幽门螺旋杆菌感染与非酒精性脂肪肝的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年08期
页码:
89-92
栏目:
论著
出版日期:
2022-04-15

文章信息/Info

Title:
Correlation Between Helicobacter Pylori Infection and Nonalcoholic Fatty Liver Disease
文章编号:
1006-1959（2022）08-0089-04
作者:
郭月欢; 甘惠中
（安徽医科大学第三附属医院消化内科，安徽 合肥 230000）
Author(s):
GUO Yue-huan; GAN Hui-zhong
(Department of Gastroenterology,the Third Affiliated Hospital of Anhui Medical University,Hefei 230000,Anhui,China)
关键词:
幽门螺旋杆菌; 非酒精性脂肪肝; 胰岛素抵抗; 非酒精性脂肪性肝炎
Keywords:
Helicobacter pylori; Non-alcoholic fatty liver disease; Insulin resistance; Nonalcoholic steatohepatitis
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2022.08.021
文献标志码:
A
摘要:
目的 探讨幽门螺旋杆菌（H.pylori）感染与非酒精性脂肪肝（NAFLD）的关系。方法 选取2019年5月-2021年6月安徽医科大学第三附属医院体检中心进行健康体检者960人，根据体检结果分为NAFLD组和非NAFLD组，比较两组临床资料及NAFLD组中H.pylori阳性与H.pylori阴性者临床资料，采用多因素Logistic回归分析NAFLD的危险因素。结果 NAFLD组吸烟史、高血压病史、糖尿病病史、H.pylori阳性检出率、颈部血管斑块检出率、BMI、ALT、AST、GGT、ALP、TG、TC、LDL-C、尿酸、HbA1c水平高于非NAFLD组，HDL-C水平低于非NAFLD组，差异有统计学意义（P＜0.05）；H.pylori阳性者高血压病史、颈部血管斑块检出率、BMI、TC、LDL-C高于H.pylori阴性者，差异有统计学意义（P＜0.05）；多因素Logistic回归分析显示，BMI、TG、HbA1c、H.pylori感染是NAFLD的相关因子（P＜0.05）。结论 NAFLD与肥胖、H.pylori感染、TG、HbA1c水平升高有关，H.pylori可能通过干扰脂质代谢和胰岛素敏感性参与NAFLD的发展。
Abstract:
Objective To investigate the relationship between Helicobacter pylori (H.pylori) infection and non-alcoholic fatty liver disease (NAFLD).Methods A total of 960 healthy people who underwent physical examination in the Physical Examination Center of the Third Affiliated Hospital of Anhui Medical University from May 2019 to June 2021 were selected as subjects. According to the physical examination results, they were divided into NAFLD group and non-NAFLD group. The clinical data of the two groups and the clinical data of H.pylori positive and H.pylori negative patients in the NAFLD group were compared. The risk factors of NAFLD were analyzed by multivariate Logistic regression.Results The smoking history, hypertension history, diabetes history, H.pylori positive detection rate, cervical vascular plaque detection rate, BMI, ALT, AST, GGT, ALP, TG, TC, LDL-C, uric acid and HbA1c levels in NAFLD group were higher than those in non- NAFLD group, and HDL-C level was lower than that in non- NAFLD group, the difference was statistically significant (P<0.05). The history of hypertension, detection rate of carotid plaque, BMI, TC and LDL-C in H.pylori positive patients were higher than those in H.pylori negative patients, and the difference was statistically significant (P<0.05). Multivariate Logistic regression analysis showed that BMI, TG, HbA1c and H.pylori infection were related factors of NAFLD (P<0.05).Conclusion NAFLD is associated with obesity, H.pylori infection, elevated TG and HbA1c levels. H.pylori may be involved in the development of NAFLD by interfering with lipid metabolism and insulin sensitivity.

参考文献/References:

[1]Eslam M,Newsome PN,Sarin SK,et al.A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement[J].J Hepatol,2020,73(1):202-209.[2]Pappachan JM,Antonio FA,Edavalath M,et al.Non-alcoholic fatty liver disease: a diabetologist’s perspective[J].Endocrine,2014,45(3):344-353.[3]Fazel Y,Koenig AB,Sayiner M,et al.Epidemiology and natural history of non-alcoholic fatty liver disease[J].Metabolism,2016,65(8):1017-1025.[4]Kountouras J,Papaefthymiou A,Doulberis M,et al.Influence of Helicobacter pylori-connected metabolic syndrome on non-alcoholic fatty liver disease and its related colorectal neoplasm high risk[J].Liver Int,2020,40(2):475-476.[5]Abdel-Razik A,Mousa N,Shabana W,et al.Helicobacter pylori and non-alcoholic fatty liver disease: A new enigma?[J].Helicobacter,2018,23(6):e12537.[6]Jiang T,Chen X,Xia C,et al.Association between Helicobacter pylori infection and non-alcoholic fatty liver disease in north Chinese: a cross-sectional study[J].Sci Rep,2019(9):4874.[7]Kim TJ,Sinn DH,Min YW,et al.A cohort study on Helicobacter pylori infection associated with nonalcoholic fatty liver disease[J].J Gastroenterol,2017,52(11):1201-1210.[8]Xu MY,Ma JH,Du J,et al.Nonalcoholic Fatty Liver Disease Is Associated with Helicobacter pylori Infection in North Urban Chinese: A Retrospective Study[J].Gastroenterol Res Pract,2020(2020):9797841.[9]Okushin K,Takahashi Y,Yamamichi N,et al.Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan[J].BMC Gastroenterol,2015(15):25.[10]Fan N,Peng L,Xia Z,et al.Helicobacter pylori Infection Is Not Associated with Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study in China[J].Front Microbiol,2018(9):73.[11]Mohammadifard M,Saremi Z,Rastgoo M,et al.Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand,Iran[J].J Med Life,2019,12(2):168-172.[12]中国肥胖问题工作组.中国成人超重和肥胖症预防与控制指南(节录)[J].营养学报,2004(1):1-4.[13]刘文忠,谢勇,陆红,等.第五次全国幽门螺杆菌感染处理共识报告[J].中华内科杂志,2017,56(7):532-545.[14]范建高.中国非酒精性脂肪性肝病诊疗指南(2010年修订版)[J].中国医学前沿杂志(电子版),2012,4(07):4-10.[15]Doulberis M,Srivastava S,Polyzos SA,et al.Active Helicobacter pylori infection is independently associated with nonalcoholic steatohepatitis in morbidly obese patients[J].J Clin Med,2020,9(4):933.[16]Abo-Amer YE,Sabal A,Ahmed R,et al.Relationship Between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease (NAFLD) in a Developing Country: A Cross-Sectional Study[J].Diabetes Metab Syndr Obes,2020(13):619-625.[17]Diehl AM,Day C.Cause,Pathogenesis,and Treatment of Nonalcoholic Steatohepatitis[J].N Engl J Med,2017,377(21):2063-2072.[18]Cai O,Huang Z,Li M,et al.Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study[J].Gastroenterol Res Pract,2018(2018):8040262.[19]Buzzetti E,Pinzani M,Tsochatzis EA.The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)[J].Metabolism,2016,65(8):1038-1048.

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更新日期/Last Update: 1900-01-01