[1]周贤位,杨水秀,肖文革,等.梅毒患者血清学检测结果分析[J].医学信息,2022,35(11):16-18.[doi:10.3969/j.issn.1006-1959.2022.11.005]
　ZHOU Xian-wei,YANG Shui-xiu,XIAO Wen-ge,et al.Analysis of Serological Test Results of Syphilis Patients[J].Medical Information,2022,35(11):16-18.[doi:10.3969/j.issn.1006-1959.2022.11.005]
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梅毒患者血清学检测结果分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
16-18
栏目:
公共卫生信息学
出版日期:
2022-06-01

文章信息/Info

Title:
Analysis of Serological Test Results of Syphilis Patients
文章编号:
1006-1959（2022）11-0016-03
作者:
周贤位; 杨水秀; 肖文革; 等
（1.贵阳市第一人民医院检验科，贵州 贵阳 550005；2.贵阳市公共卫生救治中心血透室，贵州 贵阳 550001）
Author(s):
ZHOU Xian-wei; YANG Shui-xiu; XIAO Wen-ge; et al.
(1.Department of Laboratory Medicine,the First People’s Hospital of Guiyang,Guiyang 550005,Guizhou,China;2.Hemodialysis Room of Guiyang Public Health Clinical Center,Guiyang 550001,Guizhou,China)
关键词:
梅毒; 梅毒血清学; ELISA; TRUST
Keywords:
Syphilis; Syphilis serology; ELISA; TRUST
分类号:
R759.1
DOI:
10.3969/j.issn.1006-1959.2022.11.005
文献标志码:
A
摘要:
目的 分析梅毒患者血清学检测结果的分布情况，为本地区的梅毒临床诊疗及预防提供实验依据。方法 收集2015年1月-2019年12月在贵阳市第一人民医院就诊检查梅毒的患者123 950例，用酶联免疫吸附试验（ELISA）和梅毒甲苯胺红不加热血清试验（TRUST）进行检测，将检测结果按年份、来源、性别、年龄和方法进行分组整理并分析。结果 ELISA和TRUST检出梅毒抗体阳性例数分别为5571例、1441例，ELISA总阳性率为4.49%,高于TRUST总阳性率的1.16%，差异有统计学意义（P＜0.05）；门诊梅毒ELISA和TRUST检测抗体阳性率分别为5.98%和2.51%，高于住院的4.26%和1.05%，差异有统计学意义（P＜0.05）；男性梅毒ELISA和TRUST检测抗体阳性率分别为5.25%和1.56%，高于女性的3.71%和0.91%，差异有统计学意义（P＜0.05）；不同年龄段抗体阳性率不完全相同，＞60岁的阳性率最高，≤20岁阳性率最低，各年龄段间两两比较，差异有统计学意义（P＜0.05）。结论 梅毒抗体阳性率门诊高于住院，男性高于女性，随年龄增加有升高的趋势。应加强预防梅毒的宣传力度，普及梅毒血清学筛查，及早发现梅毒患者并治疗，有助于减少梅毒传播与流行。医务人员应加强自我保护意识，减少职业暴露风险；梅毒血清学检查因存在方法学的局限性，诊断时谨慎。
Abstract:
Objective To analyze the distribution of serological test results of syphilis patients, and to provide experimental basis for the clinical diagnosis, treatment and prevention of syphilis in this region.Methods A total of 123 950 patients with syphilis were collected from January 2015 to December 2019 in the First People’s Hospital of Guiyang. Enzyme-linked immunosorbent assay (ELISA) and toluidine red unheated serum test (TRUST) were used for detection. The detection results were grouped and analyzed according to year, source, gender, age and method.Results The positive cases of syphilis antibody detected by ELISA and TRUST were 5571 cases and 1441 cases, respectively, the total positive rate of ELISA was 4.49%, which was higher than that 1.16% of TRUST, and the difference was statistically significant (P<0.05). The positive rates of syphilis antibody detected by ELISA and TRUST in outpatient department were 5.98% and 2.51%, respectively, which were higher than 4.26% and 1.05% in inpatient department, and the difference was statistically significant (P<0.05). The positive rates of syphilis antibody detected by ELISA and TRUST in males were 5.25% and 1.56%, respectively, which were higher than 3.71% and 0.91% in females, and the difference was statistically significant (P<0.05). The positive rate of antibody in different age groups was not completely the same, the positive rate of >60 years old was the highest, the positive rate of ≤20 years old was the lowest, and the difference was statistically significant (P<0.05).Conclusion The positive rate of syphilis antibody in outpatient department is higher than that in inpatient department, and that in male is higher than that in female, showing an increasing trend with age. Propaganda for syphilis prevention should be strengthened, syphilis serological screening should be popularized, and early detection and treatment of syphilis patients should be carried out, which will help reduce the spread and prevalence of syphilis. Medical staff should strengthen self-protection awareness and reduce occupational exposure risks; due to the methodological limitations of syphilis serological examination, the diagnosis is cautious.

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更新日期/Last Update: 1900-01-01