[1]刘传志.小剂量秋水仙碱联合地塞米松对急性痛风性关节炎患者疼痛症状及不良反应的影响[J].医学信息,2022,35(17):126-128.[doi:10.3969/j.issn.1006-1959.2022.17.034]
　LIU Chuan-zhi.Effect of Low-dose colchicine Combined with Dexamethasone on Pain Symptoms and Adverse Reactions in Patients with Acute Gouty Arthritis[J].Journal of Medical Information,2022,35(17):126-128.[doi:10.3969/j.issn.1006-1959.2022.17.034]
点击复制

小剂量秋水仙碱联合地塞米松对急性痛风性关节炎患者疼痛症状及不良反应的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
126-128
栏目:
药物与临床
出版日期:
2022-09-01

文章信息/Info

Title:
Effect of Low-dose colchicine Combined with Dexamethasone on Pain Symptoms and Adverse Reactions in Patients with Acute Gouty Arthritis
文章编号:
1006-1959（2022）17-0126-03
作者:
刘传志
（赣州市蓉江新区红十字会医院外科，江西 赣州 341400）
Author(s):
LIU Chuan-zhi
(Department of Surgery,Red Cross Hospital,Rongjiang New District,Ganzhou 341400,Jiangxi,China)
关键词:
痛风性关节炎; 痛风性关节炎; 地塞米松; 疼痛症状; 不良反应
Keywords:
Gouty arthritis; Gouty arthritis; Dexamethasone; Pain symptoms; Adverse reactions
分类号:
R589.7
DOI:
10.3969/j.issn.1006-1959.2022.17.034
文献标志码:
A
摘要:
目的 研究小剂量秋水仙碱联合地塞米松对急性痛风性关节炎（GA）患者疼痛症状及不良反应的影响。方法 选取2018年1月-2021年7月江西省赣州市蓉江新区红十字会医院外科收治的60例急性GA病例，按照随机数字表法分为对照组与观察组，各30例。对照组给予常规剂量秋水仙碱治疗，观察组应用小剂量秋水仙碱联合地塞米松治疗，比较两组临床疗效、疼痛症状[疼痛视觉模拟评分（VAS）、压痛关节数]、血清生化指标[血尿酸（UA）、血沉（ESR）、C反应蛋白（CRP）]、不良反应。结果 观察组治疗有效率高于对照组（P＜0.05）；两组治疗后VAS评分、压痛关节数均小于治疗前，且观察组小于对照组（P＜0.05）；两组治疗后UA、ESR、CRP均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率低于对照组（P＜0.05）。结论 小剂量秋水仙碱联合地塞米松治疗急性GA疗效确切，可显著降低患者疼痛症状，改善生化指标，且不良反应少，安全性高。
Abstract:
Objective To study the effect of low-dose colchicine combined with dexamethasone on pain symptoms and adverse reactions in patients with acute gouty arthritis (GA).Methods Sixty cases of acute GA admitted to the Department of Surgery, Red Cross Hospital, Rongjiang New District, Ganzhou City, Jiangxi Province from January 2018 to July 2021 were selected and divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with conventional dose of colchicine, while the observation group was treated with low-dose colchicine combined with dexamethasone. The clinical efficacy, pain symptoms [visual analogue scale (VAS), tenderness joint count], serum biochemical indexes [uric acid (UA), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP)] and adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). After treatment, the VAS score and the number of tender joints in the two groups were less than those before treatment, and those in the observation group were less than the control group (P<0.05). After treatment, UA, ESR and CRP in the two groups were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P<0.05).Conclusion Low-dose colchicine combined with dexamethasone is effective in the treatment of acute GA, which can significantly reduce the pain symptoms of patients, improve biochemical indicators, and have fewer adverse reactions and high safety.

参考文献/References:

[1]卢晓静,周志安,苏彬,等.痛风性关节炎患者苯溴马隆联合糖皮质激素治疗对患者临床效果与ASTALTUA水平的影响[J].河北医学,2021,27(1):125-128.[2]朱逸宸,王庄平.地塞米松联合塞来昔布治疗膝关节骨性关节炎[J].中国矫形外科杂志,2021,29(1):82-84.[3]王俊丽,冯艳广,魏琴.复方倍他米松肌注联合小剂量秋水仙碱口服治疗急性痛风性关节炎患者的疗效及安全性分析[J].云南医药,2020,41(6):565-567.[4]Palabindala V.Guideline: In acute gout, steroids, NSAIDs, or low-dose colchicine recommended; lifestyle changes not supported[J].Annals of Internal Medicine,2017,166(4):JC14.[5]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志,2011(6):410-413.[6]李茹茹.秋水仙碱联合非布司他治疗痛风性关节炎40例临床观察[J].风湿病与关节炎,2020,9(10):18-19,43.[7]Bartholomew S,Young A.Open-label randomized pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care[J].The Journal of Emergency Medicine,2020,59(2):336-337.[8]李青.我国川东北地区痛风患者痛风石形成的相关危险因素及其治疗后的疗效评价分析[D].南充:川北医学院,2018.[9]刘长鑫.小剂量秋水仙碱联合糖皮质激素治疗急性痛风性关节炎的临床研究[J].首都食品与医药,2019,26(1):31.[10]黄晓璐.秋水仙碱片内服联合氟比洛芬巴布膏外敷治疗急性痛风性关节炎的临床疗效及安全性[J].临床合理用药杂志,2018,11(36):29-30.[11]刘元德,李昊.小剂量秋水仙碱联合美洛昔康治疗痛风性关节炎疗效观察[J].海南医学,2018,29(17):2486-2489.[12]韦琪,覃玲.小剂量秋水仙碱联合塞来昔布治疗质子泵抑制剂诱使有痛风病史的上消化道出血患者发生急性痛风性关节炎的疗效观察[J].中国医院用药评价与分析,2017,17(9):1196-1197,1200.[13]杜文秀,任艺,李亮,等.大剂量秋水仙碱中毒病例报道及文献回顾[J].东南国防医药,2019,21(2):202-204.[14]许冰馨,王琪珊,李钦,等.地塞米松对CIA大鼠DRG中炎症因子的抑制和关节疼痛的改善作用[J].中国药理学通报,2020,36(12):1691-1696.[15]招淑珠,郭紫石,于清宏,等.地塞米松棕榈酸酯注射液治疗急性痛风性关节炎的临床疗效和安全性研究[J].新医学,2018,49(11):821-827.[16]刘军慧,钟飞,韩少玲,等.秋水仙碱、苯溴马隆胶囊联合治疗痛风性关节炎非急性发作期[J].昆明医科大学学报,2018,39(2):71-75.[17]杨二丽,李向红.秋水仙碱联合非甾体抗炎药在急性痛风中的临床分析[J].中国继续医学教育,2018,10(2):119-121.[18]杨彦龙,李小琴,史静,等.小剂量秋水仙碱联合得宝松治疗急性痛风性关节炎的疗效分析[J].检验医学与临床,2016,13(15):2103-2105,2108.[19]陆世凯.不同剂量秋水仙碱治疗痛风性关节炎患者的临床效果比较[J].中华全科医学,2017,15(10):1700-1703.[20]黄芳.不同剂量的秋水仙碱联合地塞米松治疗急性痛风性关节炎的疗效分析[J].现代诊断与治疗,2018,29(5):714-715.[21]柯渠青,邱晓堂,黄妮.小剂量秋水仙碱联合依托考昔治疗急性痛风性关节炎的临床观察[J].中国医药导报,2016,13(33):129-132.[22]Yamanaka H,Tamaki S,Ide Y,et al.Stepwise dose increase of febuxostat is comparable with colchicine prophylaxis for the prevention of gout flares during the initial phase of urate-lowering therapy: results from FORTUNE-1, a prospective, multicentre randomised study[J].Annals of the Rheumatic Diseases,2018,77(2):270-276.[23]章丽和,金珍木,李素蘋.秋水仙碱对痛风性关节炎患者肿瘤标志物的影响[J].医学研究杂志,2017,46(12):154-156,164.[24]马亚萍.小剂量激素治疗急性痛风性关节炎58例[J].陕西医学杂志,2016,45(3):352-353.[25]刘颖,李志琛,陈建斌,等.小剂量秋水仙碱联合糖皮质激素治疗急性痛风性关节炎的疗效观察[J].解放军医学杂志,2015,40(8):652-655.[26]冯耀然.小剂量激素与秋水仙碱治疗急性痛风性关节炎的临床效果[J].慢性病学杂志,2020,21(8):1233-1235.

相似文献/References:

[1]史世华,马天洪,山家玥,等.中药汤剂联合西药口服治疗痛风性关节炎预后的Meta分析[J].医学信息,2018,31(19):131.[doi:10.3969/j.issn.1006-1959.2018.19.039]
　SHI Shi-hua,MA Tian-hong,SHAN Jia-yue,et al.Meta-analysis of the Prognosis of Oral Traditional Chinese Medicine Decoction Combined with Western Medicine in the Treatment of Gouty Arthritis[J].Journal of Medical Information,2018,31(17):131.[doi:10.3969/j.issn.1006-1959.2018.19.039]
[2]赖 超,余 辉,向子云,等.双能量CT痛风识别技术评估痛风性关节炎的临床应用研究[J].医学信息,2018,31(24):52.[doi:10.3969/j.issn.1006-1959.2018.24.014]
　LAI Chao,YU Hui,XIANG Zi-yun,et al.Clinical Application of Dual Energy CT Gout Recognition Technique in the Evaluation of Gouty Arthritis[J].Journal of Medical Information,2018,31(17):52.[doi:10.3969/j.issn.1006-1959.2018.24.014]
[3]崔延军,梁学振,蒋雪梅,等.膝关节痛风性关节炎的超声诊断价值[J].医学信息,2020,33(01):171.[doi:10.3969/j.issn.1006-1959.2020.01.057]
　CUI Yan-jun,LIANG Xue-zhen,JIANG Xue-mei,et al.The Diagnostic Value of Knee Joint Gouty Arthritis[J].Journal of Medical Information,2020,33(17):171.[doi:10.3969/j.issn.1006-1959.2020.01.057]
[4]郑 永,张开伟.基于数据挖掘中医药治疗痛风性关节炎的用药特点[J].医学信息,2020,33(21):14.[doi:10.3969/j.issn.1006-1959.2020.21.005]
　ZHENG Yong,ZHANG Kai-Wei.Based on Data Mining Characteristics of Traditional Chinese Medicine in the Treatment of Gouty Arthritis[J].Journal of Medical Information,2020,33(17):14.[doi:10.3969/j.issn.1006-1959.2020.21.005]
[5]王丽华,曾文泓,梅 鸥,等.杨凤云教授辨治急性痛风性关节炎经验[J].医学信息,2020,33(22):161.[doi:10.3969/j.issn.1006-1959.2020.22.047]
[6]范秀松,言伟强,冯 飞,等.痛风性关节炎尿酸盐结晶的危险因素分析及双能量CT成像研究[J].医学信息,2023,36(01):132.[doi:10.3969/j.issn.1006-1959.2023.01.027]
　FAN Xiu-song,YAN Wei-qiang,FENG Fei,et al.Analysis of Risk Factors for Urate Crystallization in Gouty Arthritis and its Dual-energy CT Imaging Study[J].Journal of Medical Information,2023,36(17):132.[doi:10.3969/j.issn.1006-1959.2023.01.027]
[7]梁德风,江超宇,覃姻姻,等.痛风性关节炎并发高脂血症的发病机制及从脾论治的研究现状[J].医学信息,2024,37(14):188.[doi:10.3969/j.issn.1006-1959.2024.14.040]
　LIANG De-feng,JIANH Chao-yu,QIN Yin-yin,et al.Pathogenesis of Gouty Arthritis Complicated with Hyperlipidemia and the Research Status of Treatment from the Spleen[J].Journal of Medical Information,2024,37(17):188.[doi:10.3969/j.issn.1006-1959.2024.14.040]

更新日期/Last Update: 1900-01-01