[1]于肖肖,沈永明.CAR-T细胞疗法中细胞因子释放综合征的研究进展[J].医学信息,2022,35(21):167-170.[doi:10.3969/j.issn.1006-1959.2022.21.045]
 YU Xiao-xiao,SHEN Yong-ming.Research Progress of Cytokine Release Syndrome in CAR-T Cell Therapy[J].Journal of Medical Information,2022,35(21):167-170.[doi:10.3969/j.issn.1006-1959.2022.21.045]
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CAR-T细胞疗法中细胞因子释放综合征的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
167-170
栏目:
综述
出版日期:
2022-11-01

文章信息/Info

Title:
Research Progress of Cytokine Release Syndrome in CAR-T Cell Therapy
文章编号:
1006-1959(2022)21-0167-04
作者:
于肖肖沈永明
(天津市儿童医院检验科,天津 300134)
Author(s):
YU Xiao-xiaoSHEN Yong-ming
(Department of Laboratory,Tianjin Children’s Hospital,Tianjin 300134,China)
关键词:
嵌合抗原受体-T细胞细胞因子释放综合征巨噬细胞
Keywords:
Chimeric antigen receptor-T cellCytokine release syndromeMacrophages
分类号:
R392.12
DOI:
10.3969/j.issn.1006-1959.2022.21.045
文献标志码:
A
摘要:
嵌合抗原受体(chimeric antigen receptor,CAR)-T细胞疗法是通过基因工程手段使T细胞表达非MHC限制来直接识别靶抗原,从而精准杀伤肿瘤细胞的一种方法。目前,该疗法在B系血液系统肿瘤和多发性骨髓瘤的治疗过程中已经取得了显著的临床效果,近几年FDA也相继批准了多款CAR-T细胞产品上市。尽管CAR-T细胞疗法在癌症的治疗过程中表现出了巨大的潜力,但在治疗过程中仍有超过50%的患者会出现严重的治疗相关毒性,其中最常见且最严重的是细胞因子释放综合征(cytokine release syndrome,CRS)。本文围绕CAR的结构、CRS的概念和分级、CRS的发生机制和药物管理以及如何通过优化CAR结构等策略来减少CRS的发生进行综述,以期为临床治疗提供一定的参考价值。
Abstract:
Chimeric Antigen Receptor (CAR)-T cell therapy is a method to directly recognize target antigens by genetically engineering T cells to express non-MHC restriction, thereby accurately killing tumor cells. At present, the therapy has achieved significant clinical effects in the treatment of B-line hematological tumors and multiple myeloma. In recent years, the FDA has successively approved a number of CAR-T cell products. Although CAR-T cell therapy has shown great potential in the treatment of cancer, more than 50% of patients still experience severe treatment-related toxicity during the treatment, the most common and most serious of which is cytokine release syndrome (cytokine release syndrome, CRS). This article focuses on the structure of CAR, the concept and classification of CRS, the mechanism and drug management of CRS, and how to reduce the occurrence of CRS by optimizing the structure of CAR, in order to provide a certain reference value for clinical treatment.

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更新日期/Last Update: 1900-01-01