[1]王 杰,骆寅峰.辛伐他汀联合美多巴治疗老年患者帕金森病伴动脉粥样硬化的疗效观察[J].医学信息,2023,36(02):134-137.[doi:10.3969/j.issn.1006-1959.2023.02.028]
　WANG Jie,LUO Yin-feng.Efficacy Observation of Simvastatin Combined with Madopar in the Treatment of Parkinson’s Disease with Atherosclerosis in Elderly Patients[J].Journal of Medical Information,2023,36(02):134-137.[doi:10.3969/j.issn.1006-1959.2023.02.028]
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辛伐他汀联合美多巴治疗老年患者帕金森病伴动脉粥样硬化的疗效观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
134-137
栏目:
药物与临床
出版日期:
2023-01-15

文章信息/Info

Title:
Efficacy Observation of Simvastatin Combined with Madopar in the Treatment of Parkinson’s Disease with Atherosclerosis in Elderly Patients
文章编号:
1006-1959（2023）02-0134-04
作者:
王 杰; 骆寅峰
（佳木斯市中心医院康复科，黑龙江 佳木斯 154002）
Author(s):
WANG Jie; LUO Yin-feng
(Department of Rehabilitation,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
辛伐他汀; 美多巴; 老年帕金森; 动脉粥样硬化
Keywords:
Simvastatin; Madopar; Elderly Parkinson’s disease; Atherosclerosis
分类号:
R742.5；R543.5
DOI:
10.3969/j.issn.1006-1959.2023.02.028
文献标志码:
A
摘要:
目的 观察辛伐他汀联合美多巴治疗老年患者帕金森病伴动脉粥样硬化的疗效。方法 选取2020年1月-2021年8月在我院诊治的52例老年帕金森病伴动脉粥样硬化患者为研究对象，采用随机数字表法分为对照组和观察组，各26例。对照组采用美多巴治疗，观察组在对照组基础上联合辛伐他汀治疗。比较两组临床治疗总有效率、改良Webster PD功能障碍评分、日常生活能力评分、神经临床症状评分、血清Cys-C、Hcy水平以及临床不良反应发生情况。结果 观察组治疗总有效率为92.31%，高于对照组的80.77%（P＜0.05）；两组Webster PD评分均低于治疗前，日常生活能力各维度评分均高于治疗前，且观察组Webster PD评分低于对照组，日常生活能力各维度评分高于对照组（P＜0.05）；观察组口干、出汗、尿频尿急、便秘、流涎评分均低于对照组（P＜0.05）；观察组Cys-C、Hcy水平均低于治疗前，且观察组低于对照组（P＜0.05），对照组与治疗前比较，差异无统计学意义（P＞0.05）；观察组不良反应发生率为7.69%，低于对照组的19.23%（P＜0.05）。结论 辛伐他汀联合美多巴治疗老年患者帕金森病伴动脉粥样硬化效果明确，且可改善患者动脉粥样硬化，促进患者神经症状改善，提高患者日常生活能力，且可降低不良反应发生率，是一种有效、安全的治疗方案。
Abstract:
Objective To observe the efficacy of simvastatin combined with madopar in the treatment of Parkinson’s disease with atherosclerosis in elderly patients.Methods A total of 52 elderly patients with Parkinson’s disease and atherosclerosis who were treated in our hospital from January 2020 to August 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 26 cases in each group. The control group was treated with Madopar, and the observation group was treated with simvastatin on the basis of the control group. The total effective rate of clinical treatment, modified Webster PD dysfunction score, daily living ability score, neurological clinical symptom score, serum Cys-C, Hcy level and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.31%, which was higher than 80.77% in the control group (P<0.05). The Webster PD scores of the two groups were lower than those before treatment, and the scores of each dimension of daily living ability were higher than those before treatment, while the Webster PD score of the observation group was lower than that of the control group, and the scores of each dimension of daily living ability were higher than those of the control group (P<0.05). The scores of dry mouth, sweating, frequent urination, urgency, constipation and salivation in the observation group were lower than those in the control group (P<0.05). The levels of Cys-C and Hcy in the observation group were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). There was no significant difference between the control group and before treatment (P>0.05). The incidence of adverse reactions in the observation group was 7.69%, which was lower than 19.23% in the control group (P<0.05).Conclusion Simvastatin combined with madopar is effective in the treatment of Parkinson’s disease with atherosclerosis in elderly patients, which can improve atherosclerosis, promote the improvement of neurological symptoms, improve the daily living ability of patients, and reduce the incidence of adverse reactions. It is an effective and safe treatment.

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更新日期/Last Update: 1900-01-01