[1]刘 兰,张远哲,陈 铭.基于网络药理学探讨黄连温胆汤治疗失眠的作用机制[J].医学信息,2023,36(03):10-14.[doi:10.3969/j.issn.1006-1959.2023.03.003]
　LIU Lan,ZHANG Yuan-zhe,CHEN Ming.The Mechanism of Huanglian Wendan Decoction in the Treatment of Insomnia Based on Network Pharmacology[J].Journal of Medical Information,2023,36(03):10-14.[doi:10.3969/j.issn.1006-1959.2023.03.003]
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基于网络药理学探讨黄连温胆汤治疗失眠的作用机制()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年03期
页码:
10-14
栏目:
中医药信息学
出版日期:
2023-02-01

文章信息/Info

Title:
The Mechanism of Huanglian Wendan Decoction in the Treatment of Insomnia Based on Network Pharmacology
文章编号:
1006-1959（2023）03-0010-05
作者:
刘 兰; 张远哲; 陈 铭
（1.常德职业技术学院基础医学院，湖南 常德 415000；2.贵州中医药大学基础医学院，贵州 贵阳 550025）
Author(s):
LIU Lan; ZHANG Yuan-zhe; CHEN Ming
(1.School of Basic Medicine,Changde Vocational Technical College,Changde 415000,Hunan,China;2.College of Basic Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China)
关键词:
黄连温胆汤; 失眠; 网络药理学; 靶点; 抗炎作用
Keywords:
Huanglian Wendan decoction; Insomnia; Network pharmacology; Target; Anti-inflammatory effect
分类号:
R285
DOI:
10.3969/j.issn.1006-1959.2023.03.003
文献标志码:
A
摘要:
目的 利用网络药理学技术探讨黄连温胆汤治疗失眠的可能作用机制。方法 收集黄连温胆汤中药化合物成分，并分别获取相对应靶标蛋白名称。获取失眠相关基因，构建药物与疾病靶点交集韦恩图。利用String数据库构建黄连温胆汤的蛋白互作网络探讨黄连温胆汤治疗失眠的机制及治疗效果。结果 黄连温胆汤主要成分对应的靶点有252个，失眠的疾病靶点2595个，交集靶点117个。黄连温胆汤治疗失眠的核心靶点为白细胞介素-6（IL6）、白细胞介素-1B（IL1B）、肿瘤坏死因子（TNF）、蛋白质激酶（AKT1），多为促炎因子，黄连温胆汤可通过抑制这些因子水平从而改善失眠。主要化合物成分为槲皮素（quercetin）、木犀草素（luteolin）、山奈酚（kaempferol），属类黄酮化合物，可与血清素系统相互作用，作为镇定剂使用和治疗失眠。结论 黄连温胆汤抑制失眠患者的炎症介质血清水平和主要化合物的催眠活性可能为黄连温胆汤治疗失眠的机制。
Abstract:
Objective To explore the possible mechanism of Huanglian Wendan decoction in treating insomnia by network pharmacology. Methods Collect the ingredients of Huanglian Wendan decoction and obtain the corresponding target protein name. Obtain insomnia gene and construct Venn diagram of intersection of drug and disease target. The protein interaction network of Huanglian Wendan decoction was constructed by String database to explore the mechanism and therapeutic effect of Huanglian Wendan decoction in the treatment of insomnia.Results There were 252 targets corresponding to the main components of Huanglian Wendan decoction, 2595 disease targets of insomnia, and 117 intersection targets. The core targets of Huanglian Wendan decoction in the treatment of insomnia are interleukin-6 (IL6), interleukin-1B (IL1B), tumor necrosis factor (TNF), and protein kinase (AKT1), which were mostly pro-inflammatory factors, while Huanglian Wendan decoction could improve insomnia by inhibiting of these factors. The main compounds were quercetin, luteolin and kaempferol. They were flavonoid compounds that interact with the serotonin system and were used as tranquilizers and to treat insomnia.Conclusion Huanglian Wendan decoction can inhibit the serum levels of inflammatory mediators and the hypnotic activity of main compounds in patients with insomnia, which may be the mechanism of Huanglian Wendan decoction in the treatment of insomnia.

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更新日期/Last Update: 1900-01-01