[1]于京虎.丙戊酸钠联合富马酸喹硫平对双相情感障碍患者躁狂症状的影响[J].医学信息,2023,36(06):150-153.[doi:10.3969/j.issn.1006-1959.2023.06.033]
　YU Jing-hu.Effect of Sodium Valproate Combined with Quetiapine Fumarate on Manic Symptoms in Patients with Bipolar Disorder[J].Journal of Medical Information,2023,36(06):150-153.[doi:10.3969/j.issn.1006-1959.2023.06.033]
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丙戊酸钠联合富马酸喹硫平对双相情感障碍患者躁狂症状的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年06期
页码:
150-153
栏目:
论著
出版日期:
2023-03-15

文章信息/Info

Title:
Effect of Sodium Valproate Combined with Quetiapine Fumarate on Manic Symptoms in Patients with Bipolar Disorder
文章编号:
1006-1959（2023）06-0150-04
作者:
于京虎
（佳木斯市精神病医院精神七科，黑龙江 佳木斯 154002）
Author(s):
YU Jing-hu
(The Seventh Department Psychiatry,Jiamusi Psychiatric Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
双相情感障碍; 躁狂症状; 抑郁症状; 炎性因子
Keywords:
Bipolar disorder; Manic symptoms; Depressive symptoms; Inflammatory factors
分类号:
R749.4
DOI:
10.3969/j.issn.1006-1959.2023.06.033
文献标志码:
A
摘要:
目的 研究丙戊酸钠联合富马酸喹硫平对双相情感障碍（BD）患者躁狂症状的影响。方法 以2018年2月-2021年12月佳木斯市精神病医院收治的76例BD患者为研究对象，按照随机数字表法分为对照组（38例）与观察组（38例）。对照组给予丙戊酸钠治疗，观察组应用丙戊酸钠联合富马酸喹硫平治疗。比较两组倍克-拉范森躁狂量表（BRMS）评分、汉密尔顿抑郁量表（HAMD）评分、综合疗效、血清炎性因子［肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）、白细胞介素-10（IL-10）］及不良反应。结果 两组BRMS评分、HAMD评分均有下降，且观察组低于对照组（P＜0.05）；观察组治疗有效率高于对照组（P＜0.05）；两组IL-10水平升高，IL-1、TNF-α下降，且观察组IL-10高于对照组，IL-1、TNF-α低于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 丙戊酸钠联合富马酸喹硫平可有效缓解BD患者的躁狂、抑郁症状，其疗效确切，可减轻体内炎性反应，且不增加不良反应。
Abstract:
Objective To study the effect of sodium valproate combined with quetiapine fumarate on manic symptoms in patients with bipolar disorder (BD).Methods From February 2018 to December 2021, 76 BD patients admitted to Jiamusi Psychiatric Hospital were selected as the research objects. According to the random number method, they were divided into control group (38 cases) and observation group (38 cases). The control group was treated with sodium valproate, and the observation group was treated with sodium valproate combined with quetiapine fumarate. The Beck-Rafaelson Mania Scale (BRMS) score, Hamilton Depression Scale (HAMD) score, comprehensive efficacy, serum inflammatory factors [tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-10 (IL-10)] and adverse reactions were compared between the two groups.Results The BRMS score and HAMD score of the two groups decreased, and those of the observation group were lower than the control group (P<0.05). The effective rate of treatment in the observation group was higher than that in the control group (P<0.05). The levels of IL-10 in the two groups increased, IL-1 and TNF-α decreased, and IL-10 in the observation group was higher than that in the control group, while IL-1 and TNF-α were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Sodium valproate combined with quetiapine fumarate can effectively alleviate the symptoms of mania and depression in patients with BD, and its curative effect is definite. Meanwhile, it can reduce the inflammatory reaction in vivo without increasing adverse reactions.

参考文献/References:

[1]Hulzen KV,Scholz CJ,Franke B,et al.Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis[J].Biological Psychiatry,2017,82(9):634-641.[2]陈策,郑丽丹,谢作良,等.双相情感障碍住院患者的临床特征及用药情况的调查研究[J].中国全科医学,2020,23(2):245-250.[3]Vancampfort D,Firth J,Schuch FB,et al.Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta‐analysis[J].World Psychiatry Official Journal of the World Psychiatric Association,2017,16(3):308-315.[4]毛希祥,陈强,柏彩云,等.丙戊酸钠静脉滴注治疗双相障碍混合发作急性期的临床观察[J].临床精神医学杂志,2020,30(4):227-229.[5]李嘉,李强,魏伟青,等.喹硫平应用于双相情感障碍的临床效果及其安全性[J].检验医学与临床,2018,15(15):2272-2275.[6]于欣,方贻儒.中国双相障碍防治指南[M].2版.北京:中华医学电子音像出版社,2016:60.[7]金庞,周波,王国民,等.阿米替林联合喹硫平对双向情感障碍患者的疗效及对TBIL和脑源性神经营养因子水平的影响[J].广东医学,2021,42(6):723-726.[8]段海水,吕贝,黄超.碳酸锂联合喹硫平治疗双相情感障碍的临床研究[J].安徽医药,2018,22(4):746-749.[9]何彦虎,金华,刘志军,等.基于“肠-脑”通路探讨帕金森病的发病机制的研究现状[J].中国临床药理学杂志,2021,37(23):3290-3294.[10]王钰.丙戊酸钠联合齐拉西酮对双相情感障碍Ⅰ型患者疗效及认知功能的影响观察[J].四川医学,2017,38(10):1182-1184.[11]Brigo F,Igwe SC,Lattanzi S.Ethosuximide,sodium valproate or lamotrigine for absence seizures in children and adolescents[J].Cochrane Database Syst Rev,2021,1(1):CD003032.[12]李芳,范悦斌,张育芬,等.碳酸锂联合富马酸喹硫平片或丙戊酸镁缓释片治疗双相情感障碍躁狂发作的疗效[J].国际精神病学杂志,2019,46(1):81-83,95.[13]丁玲,肖开提·苏理旦.喹硫平或奥氮平联合丙戊酸钠缓释片治疗维族双相障碍精神病的疗效研究[J].药物评价研究,2017,40(5):696-699.[14]魏昆岭,李钊,桑文华,等.丙戊酸钠注射液与氟哌啶醇注射液治疗不伴有精神病性症状双相障碍躁狂发作激越症状的临床研究[J].中国临床药理学杂志,2019,35(23):3006-3008,3012.[15]Stephenson CM,Bigliani V,Jones HM,et al.Striatal and extra-striatal D(2)/D(3) dopamine receptor occupancy by quetiapine in vivo.[(123)I]-epidepride single photon emission tomography(SPET) study[J].British Journal of Psychiatry,2018,177(5):408-415.[16]张龙元,谢勇,刘鳗瑶.富马酸喹硫平片联合碳酸锂缓释片对躁狂抑郁症治疗效果及认知功能的影响[J].甘肃科学学报,2019,31(4):74-78.[17]许玉玲,王茜,刘蕾.富马酸喹硫平与盐酸安非他酮治疗双相情感障碍抑郁发作的效果和安全性分析[J].医学临床研究,2019,36(3):594-596.[18]Peng X,Yan Y,Chen R,et al.Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures[J].Curr Med Res Opin,2020,36(2):271-276.[19]黄惠红,陈结南.碳酸锂联合富马酸喹硫平治疗双相情感障碍躁狂发作的疗效及对认知功能的影响[J].海南医学,2021,32(18):2345-2348.[20]斯亮,王燕燕,卢远波.喹硫平联合丙戊酸镁缓释片对双相情感障碍躁狂发作患者血清BDNF、GDNF及炎性因子水平的影响[J].川北医学院学报,2021,36(10):1383-1386.[21]Bonnín CM,Martínez-Arán A,Reinares M,et al.Thresholds for severity, remission and recovery using the functioning assessment short test (FAST) in bipolar disorder[J].Journal of Affective Disorders,2018,240:57-62.[22]曾剑飞,张英,廖春平.喹硫平联合丙戊酸镁治疗双相情感障碍的临床效果及对患者炎性因子、认知功能的影响[J].解放军医药杂志,2022,34(1):97-100.[23]李燕华,蒋婉丽.喹硫平或阿立哌唑联合丙戊酸钠治疗BPD抑郁发作疗效观察[J].西南国防医药,2018,28(11):1010-1012.[24]阿地拉·阿吉,张丞,唐潇潇,等.丙戊酸钠缓释片联合富马酸喹硫平治疗双相情感障碍的疗效与安全性[J].中国医师杂志,2021,23(7):1093-1096.

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更新日期/Last Update: 1900-01-01