[1]夏婷婷,曾克非.早卵泡期长方案与拮抗剂方案对不孕症患者子宫内膜容受性及临床妊娠的影响[J].医学信息,2023,36(12):140-143.[doi:10.3969/j.issn.1006-1959.2023.12.028]
　XIA Ting-ting,ZENG Ke-fei.Effects of Long-term Regimen and Antagonist Regimen in Early Follicular Phase on Endometrial Receptivity and Clinical Pregnancy in Infertile Patients[J].Journal of Medical Information,2023,36(12):140-143.[doi:10.3969/j.issn.1006-1959.2023.12.028]
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早卵泡期长方案与拮抗剂方案对不孕症患者子宫内膜容受性及临床妊娠的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年12期
页码:
140-143
栏目:
药物与临床
出版日期:
2023-06-15

文章信息/Info

Title:
Effects of Long-term Regimen and Antagonist Regimen in Early Follicular Phase on Endometrial Receptivity and Clinical Pregnancy in Infertile Patients
文章编号:
1006-1959（2023）12-0140-04
作者:
夏婷婷; 曾克非
（井冈山大学附属医院生殖医学科1，妇产科2，江西 吉安 343000）
Author(s):
XIA Ting-ting; ZENG Ke-fei
(Department of Reproductive Medicine1,Department of Gynaecology and Obstetrics2,Jinggangshan University Affiliated Hospital,Ji’an 343000,Jiangxi,China)
关键词:
早卵泡期长方案; 拮抗剂; 不孕症; 子宫内膜容受性; 妊娠
Keywords:
Long-term regimen in early follicular phase; Antagonist; Infertility; Endometrial receptivity;  Pregnancy
分类号:
R714
DOI:
10.3969/j.issn.1006-1959.2023.12.028
文献标志码:
A
摘要:
目的 观察早卵泡期长效长方案与拮抗剂方案对不孕症患者子宫内膜容受性及临床妊娠的影响。方法 选取2022年1月-3月在我院诊治的140例不孕症患者为研究对象。采用随机数字表法分为早卵泡期长方案组（n=70）、拮抗剂组（n=70），比较两组临床检测指标[促性腺激素（Gn）天数、Gn总量、HCG日的雌激素（E2）、子宫内膜厚度]、子宫动脉血流参数[子宫动脉的阻力指数（RI）、搏动指数（PI）、收缩峰值血流速度与舒张末期血流速度比值（S/D）]、子宫内膜容积、子宫内膜蠕动波分型、子宫内膜分型、子宫内膜超声多模态评分、优胚率、妊娠率。结果 早卵泡期长方案组Gn天数、Gn总量均大于拮抗剂组，HCG日E2、RI、PI、S/D低于拮抗剂组，子宫内膜厚度、子宫内膜容积大于拮抗剂组（P＜0.05）；两组子宫内膜蠕动波分型、子宫内膜分型比较，差异无统计学意义（P＞0.05）；早卵泡期长方案组子宫内膜超声多模态评分、优胚率、妊娠率高于拮抗剂组（P＜0.05）。结论 早卵泡期长方案对不孕症患者子宫内膜容受性及临床妊娠均具有积极的影响。虽然Gn的用量及天数均大于拮抗剂方案，但是可提高优胚率、妊娠率，改善子宫动脉血流参数，上调子宫内膜超声多模态评分，是一种较理想的促排卵方法。
Abstract:
Objective To observe the effects of long-term regimen and antagonist regimen in early follicular phase on endometrial receptivity and clinical pregnancy in infertile patients.Methods A total of 140 infertility patients diagnosed and treated in our hospital from January to March 2022 were selected as the research objects. They were divided into early follicular long-term regimen group (n=70) and antagonist group (n=70) by random number table method. The clinical detection indexes [gonadotropin (Gn) days, total Gn, estrogen (E2) on HCG day, endometrial thickness], uterine artery blood flow parameters [uterine artery resistance index (RI), pulsatility index (PI), peak systolic blood flow velocity and end diastolic blood flow velocity ratio (S/D)], endometrial volume, endometrial peristaltic wave type, endometrial type, endometrial ultrasound multimodal score, excellent embryo rate, pregnancy rate were compared between the two groups.Results The number of Gn days and the total amount of Gn in the early follicular long-term regimen group were larger than those in the antagonist group, the E2 on the HCG day, RI, PI and S/D were lower than that in the antagonist group, the endometrial thickness and volume were larger than that in the antagonist group (P<0.05). There was no significant difference in endometrial peristaltic wave type and endometrial type in the two groups(P>0.05). The endometrial ultrasound multimodal score, the excellent embryo rate and the pregnancy rate were higher than that of the antagonist group(P<0.05).Conclusion long-term regimen in early follicular phase has a positive effect on endometrial receptivity and clinical pregnancy in infertile patients. Although the dosage and number of days of Gn are greater than the antagonist regimen, it can also improve the high-quality embryo rate, pregnancy rate, uterine artery blood flow parameters, and increase the endometrial ultrasound multimodal score. It is an ideal ovulation induction method.

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更新日期/Last Update: 1900-01-01