[1]黄秋妹,阙慧卿,李 唯,等.吴茱萸碱脂质体的制备工艺研究[J].医学信息,2023,36(19):19-22.[doi:10.3969/j.issn.1006-1959.2023.19.005]
　HUANG Qiu-mei,QUE Hui-qing,LI Wei,et al.Study on the Preparation Technology of Evodiamine Liposome[J].Journal of Medical Information,2023,36(19):19-22.[doi:10.3969/j.issn.1006-1959.2023.19.005]
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吴茱萸碱脂质体的制备工艺研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年19期
页码:
19-22
栏目:
中医药信息学
出版日期:
2023-10-01

文章信息/Info

Title:
Study on the Preparation Technology of Evodiamine Liposome
文章编号:
1006-1959（2023）19-0019-04
作者:
黄秋妹; 阙慧卿; 李 唯; 等
（1.广东食品药品职业学院，广东 广州 510520；2.福建省医学科学研究院药物所福建省医学测试重点实验室，福建 福州 350001）
Author(s):
HUANG Qiu-mei; QUE Hui-qing; LI Wei; et al.
(1.Guangdong Food and Drug Vocational College,Guangzhou 510520,Guangdong,China;2.Fujian Provincial Key Laboratory of Medical Testing,Institute of Pharmaceutical Research,Fujian Academy of Medical Sciences,Fuzhou 350001,Fujian,China)
关键词:
吴茱萸碱; 脂质体; 难溶性药物; 制备工艺; 含量测定
Keywords:
Objective To optimize the preparation method of evodiamine liposomes.Methods The uniform design method was used to optimize the preparation process of evodiamine liposomes with phospholipid concentration;  phospholipid-cholesterol ratio;  drug concentration as influencing factors;  and particle size;  Zeta potential;  encapsulation efficiency as evaluation indexes.Results The optimal process of preparation of evodiamine liposomes was as follows: the phospholipid concentration 30 μmol/L、phospholipid-cholesterol ratio 1∶1 and drug concentration 0.8 μmol/L. Under these conditions; the particle size was 88.46 nm;  Zeta potential was -30.56mv;  and the encapsulation efficiency was 86.60%.Conclusion The preparation process of evodiamine liposomes is stable;  the encapsulation efficiency is good.
分类号:
R283
DOI:
10.3969/j.issn.1006-1959.2023.19.005
文献标志码:
A
摘要:
目的 优选吴茱萸碱脂质体的制备工艺。方法 以磷脂浓度、磷胆比、药物浓度为影响因素，以粒径、Zeta电位和包封率为评价指标，采用均匀设计法优选吴茱萸碱脂质体的制备工艺。结果 优选的制备工艺为：磷脂浓度为30 μmol/L，磷胆比1∶1，吴茱萸碱的浓度为0.8 μmol/L；吴茱萸碱脂质体的粒径88.46 nm，Zeta电位-30.56 mV，包封率86.60%。结论 吴茱萸碱脂质体的制备工艺稳定，包封率良好。
Abstract:
Objective To optimize the preparation method of evodiamine liposomes.Methods The uniform design method was used to optimize the preparation process of evodiamine liposomes with phospholipid concentration, phospholipid-cholesterol ratio, drug concentration as influencing factors, and particle size, Zeta potential, encapsulation efficiency as evaluation indexes.Results The optimal process of preparation of evodiamine liposomes was as follows: the phospholipid concentration 30 μmol/L、phospholipid-cholesterol ratio 1∶1 and drug concentration 0.8 μmol/L. Under these conditions，the particle size was 88.46 nm, Zeta potential was -30.56mv, and the encapsulation efficiency was 86.60%.Conclusion The preparation process of evodiamine liposomes is stable, the encapsulation efficiency is good.

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更新日期/Last Update: 1900-01-01