[1]李姗姗,刘海旺,李春辉.CNP、NPR-B与NF-κB信号通路在胃癌中的研究进展[J].医学信息,2023,36(23):165-169.[doi:10.3969/j.issn.1006-1959.2023.23.042]
 LI Shan-shan,LIU Hai-wang,LI Chun-hui.Research Progress of CNP, NPR-B and NF-κB Signaling Pathway in Gastric Cancer[J].Journal of Medical Information,2023,36(23):165-169.[doi:10.3969/j.issn.1006-1959.2023.23.042]
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CNP、NPR-B与NF-κB信号通路在胃癌中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年23期
页码:
165-169
栏目:
综述
出版日期:
2023-12-01

文章信息/Info

Title:
Research Progress of CNP, NPR-B and NF-κB Signaling Pathway in Gastric Cancer
文章编号:
1006-1959(2023)23-0165-05
作者:
李姗姗刘海旺李春辉
(承德医学院附属医院病理科,河北 承德 067000)
Author(s):
LI Shan-shanLIU Hai-wangLI Chun-hui
(Department of Pathology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)
关键词:
CNPNPR-BNF-κB信号通路胃癌
Keywords:
CNPNPR-BNF-κB signaling pathwayGastric cancer
分类号:
R735.2
DOI:
10.3969/j.issn.1006-1959.2023.23.042
文献标志码:
A
摘要:
胃癌的发生发展由多种基因及信号通路共同调控。C型钠尿肽作为钠尿肽家族的一员,通过与其特异性受体NPR-B结合激活cGMP进而调控下游信号分子发挥多种生物学作用。心房钠尿肽在胃癌中发挥着抗增殖以及抑制肿瘤迁移与转移的作用,而C型钠尿肽与心房钠尿肽结构相似,其作用的效应分子也相似,故而推测C型钠尿肽在胃癌中也有类似作用。此外,C型钠尿肽可以抑制NF-κB信号通路的激活。NF-κB信号通路的激活能够促进胃癌的发生发展,在胃癌的凋亡、增殖、侵袭与转移等多方面发挥重要作用。本文就C型钠尿肽及其功能受体NPR-B、NF-κB信号通路与胃癌发生发展的关系进行综述,旨在为科研及临床治疗提供有效的参考。
Abstract:
The development of gastric cancer is regulated by a combination of genes and signaling pathways. As a member of the natriuretic peptide family, C-type natriuretic peptide plays a variety of biological roles by activating cGMP through binding to its specific receptor NPR-B, which in turn regulates downstream signaling molecules. Atrial natriuretic peptide plays an anti-proliferative role and inhibits tumor migration and metastasis in gastric cancer, while C-type natriuretic peptide is structurally similar to atrial natriuretic peptide and its effector molecules are also similar, so it is presumed that C-type natriuretic peptide also has similar effects in gastric cancer. In addition, C-type natriuretic peptide can inhibit the activation of NF-κB signaling pathway, which can promote the development of gastric cancer and play an important role in apoptosis, proliferation, invasion and metastasis of gastric cancer. The article reviews the relationship between the C-type natriuretic peptide, NPR-B and NF-κB signaling pathway and the development of gastric cancer, aiming to provide effective reference values for scientific research and clinical treatment.

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更新日期/Last Update: 1900-01-01