[1]范东庭.阿托伐他汀钙改善慢性硬膜下血肿出血量及神经功能的价值[J].医学信息,2024,37(17):93-96.[doi:10.3969/j.issn.1006-1959.2024.17.018]
　FAN Dong-ting.Value of Atorvastatin Calcium in Improving the Amount of Bleedingand Neurological Function of Chronic Subdural Hematoma[J].Journal of Medical Information,2024,37(17):93-96.[doi:10.3969/j.issn.1006-1959.2024.17.018]
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阿托伐他汀钙改善慢性硬膜下血肿出血量及神经功能的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年17期
页码:
93-96
栏目:
论著
出版日期:
2024-09-01

文章信息/Info

Title:
Value of Atorvastatin Calcium in Improving the Amount of Bleedingand Neurological Function of Chronic Subdural Hematoma
文章编号:
1006-1959（2024）17-0093-04
作者:
范东庭
寻乌县人民医院神经外科，江西 寻乌 342200
Author(s):
FAN Dong-ting
Department of Neurosurgery,Xunwu County People’s Hospital,Xunwu 342200,Jiangxi,China
关键词:
阿托伐他汀钙; 慢性硬膜下血肿; 出血量; 神经功能
Keywords:
Atorvastatin calcium; Chronic subdural hematoma; The amount of bleeding; Neurological function
分类号:
R651
DOI:
10.3969/j.issn.1006-1959.2024.17.018
文献标志码:
A
摘要:
目的 观察阿托伐他汀钙改善慢性硬膜下血肿出血量及神经功能的价值。方法 选取2019年5月-2023年5月在我院诊治的62例慢性硬膜下血肿患者为研究对象，采用随机数字表法分为对照组和观察组，各组31例。对照组给予常规对症治疗，观察组在对照组基础上联合应用阿托伐他汀钙治疗。比较两组临床疗效、不同时间硬膜下血肿出血量、神经功能缺损（CSS）评分、日常生活活动能力量表（BI）评分、复发率及不良反应发生率。结果 观察组治疗总有效率（93.55%）高于对照组（80.65%）（P＜0.05）；治疗1周、2周后观察组硬膜下血肿出血量均小于对照组（P＜0.05）；两组CSS评分均低于治疗前，且观察组低于对照组（P＜0.05）；两组BI评分均高于治疗前，且观察组高于对照组（P＜0.05）；随访2个月，观察组复发率（3.23%）低于对照组（16.13%）（P＜0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）。结论 阿托伐他汀钙治疗慢性硬膜下血肿具有显著的效果，可提高治疗效果，减少出血量，改善患者神经功能缺损和日常生活活动能力，降低复发率，且不增加不良反应，值得临床应用。
Abstract:
Objective To observe the value of atorvastatin calcium in improving the amount of bleeding and neurological function of chronic subdural hematoma.Methods A total of 62 patients with chronic subdural hematoma diagnosed and treated in our hospital from May 2019 to May 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 31 patients in each group. The control group was given routine symptomatic treatment, and the observation group was treated with atorvastatin calcium on the basis of the control group. The clinical efficacy, the amount of subdural hematoma at different time, neurological deficit score (CSS), activity of daily living scale score (BI), recurrence rate and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group (93.55%) was higher than that of the control group (80.65%) (P<0.05). After 1 and 2 weeks of treatment, the amount of subdural hematoma in the observation group was less than that in the control group (P<0.05). The CSS score of the two groups was lower than that before treatment, and that of the observation group was lower than that of the control group (P<0.05). The BI score of the two groups was higher than that before treatment, and that of the observation group was higher than that of the control group (P<0.05). After 2 months of follow-up, the recurrence rate of the observation group (3.23%) was lower than that of the control group (16.13%) (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).Conclusion Atorvastatin calcium has a significant effect in the treatment of chronic subdural hematoma, which can improve the therapeutic effect, reduce the amount of bleeding, improve the neurological deficit and activities of daily living, reduce the recurrence rate, and do not increase the risk of adverse reactions. It is worthy of clinical application.

参考文献/References:

[1]潘文,王振强,高原,等.不同剂量阿托伐他汀辅助钻孔引流术治疗慢性硬膜下血肿的疗效及安全性[J].中国老年学杂志,2017,37(24):6162-6164.[2]谢琳,李凯舒,田立美,等.口服阿托伐他汀钙片联合钻孔引流术治疗慢性硬膜下血肿的疗效分析[J].岭南现代临床外科,2017,17(6):721-724.[3]周宇,陈淳,邓发斌,等.不同剂量阿托伐他汀对慢性硬膜下血肿的疗效及安全性评价[J].中国药房,2017,28(5):663-667.[4]李晓良,任光辉.钻孔引流术联合阿托伐他汀治疗慢性硬膜下血肿的效果[J].精准医学杂志,2019,34(3):234-236.[5]旷仁钊,李舜,唐文国,等.钻孔引流改进术治疗慢性硬膜下血肿减少远离术区颅内出血风险[J].中国神经精神疾病杂志,2019,45(1):7-10.[6]刘强,庞绍铮.慢性硬膜下血肿术后应用阿托伐他汀降低复发的效果分析[J].江苏医药,2019,45(5):534-536.[7]费舟,冯华,康德智,等.慢性硬膜下血肿药物治疗专家共识[J].中华医学杂志,2020,100(8):566-570.[8]陈锐锋,朱安林.微创钻孔引流术联合阿托伐他汀对慢性硬膜下血肿患者术后并发症及复发率的影响[J].安徽医学,2019,40(1):62-64. [9]Kotwica Z,Saracen A,Dziuba I.Chronic subdural hematoma (CSH) is still an important clinical problem.Analysis of 700 consecutive patients[J].Transl Neurosci,2019,10:260-263.[10]张蕾,侯梅英,程刚,等.钻孔尿激酶注入联合阿托伐他汀钙对慢性硬膜下血肿患者术后神经功能及预后的临床观察[J].河北医药,2018,40(20):3137-3140.[11]李东海,王崇科,方孟秋,等.地塞米松降低慢性硬膜下血肿患者再手术率的作用分析[J].中国实用神经疾病杂志,2017,20(21):45-47.[12]张春良,朱峰,陈雪飞,等.云南红药胶囊联合阿托伐他汀治疗术后复发性慢性硬膜下血肿疗效及对血清 IL-6、VEGF、MMP-9、D-二聚体水平的影响[J].现代中西医结合杂志,2018,27(28):3090-3093,3097.[13]邹超,周晓平,岳志健,等.阿托伐他汀钙配合单孔双管冲洗引流治疗慢性硬膜下血肿疗效分析[J].第二军医大学学报,2018,39(12):1400-1402.[14]李新,钱兴龙,周明,等.阿托伐他汀联合钻颅冲洗外引流术治疗慢性硬膜下血肿临床疗效观察[J].中国社区医师,2018,34(25):30,32.[15]张朋.阿托伐他汀钙辅助治疗对慢性硬膜下血肿患者术后神经功能及复发率的影响[J].河南医学研究,2019,28(14):2599-2600.[16]孙季威,张鹏,郑红绪,等.钻孔引流术术中生理盐水冲洗联合术后阿托伐他汀口服对慢性硬膜下血肿短期疗效分析[J].包头医学院学报,2020,36(12):57-60.[17]钟鸣谷,古机泳,张伟明,等.阿托伐他汀辅助钻孔引流术治疗慢性硬膜下血肿的临床疗效[J].山西医药杂志,2020,49(24):3416-3419.[18]肖羽.阿托伐他汀对慢性硬膜下血肿患者术后血肿残留量和神经功能的影响[J].慢性病学杂志,2020,21(8):1207-1208,1211.[19]卢伟坤,梁楚砺.阿托伐他汀治疗慢性硬膜下血肿的疗效观察[J].现代诊断与治疗,2020,31(11):1747-1749.[20]杨俊勇,王剑,聂君英.阿托伐他汀治疗慢性硬膜下血肿效果观察[J].临床合理用药杂志,2018,11(25):63-64.

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更新日期/Last Update: 1900-01-01