[1]孙嘉雯,赵肖灵,张小冲,等.可切除胃食管交界腺癌免疫治疗的研究现状[J].医学信息,2024,37(20):188-192.[doi:10.3969/j.issn.1006-1959.2024.20.041]
 SUN Jiawen,ZHAO Xiaoling,ZHANG Xiaochong,et al.Research Status of Immunotherapy for Resectable Gastroesophageal Junction Adenocarcinoma[J].Journal of Medical Information,2024,37(20):188-192.[doi:10.3969/j.issn.1006-1959.2024.20.041]
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可切除胃食管交界腺癌免疫治疗的研究现状()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年20期
页码:
188-192
栏目:
综述
出版日期:
2024-10-15

文章信息/Info

Title:
Research Status of Immunotherapy for Resectable Gastroesophageal Junction Adenocarcinoma
文章编号:
1006-1959(2024)20-0188-05
作者:
孙嘉雯12赵肖灵2张小冲2王继涛2刘登湘2
1.承德医学院研究生学院,河北 承德 067000;2.邢台市人民医院肿瘤实验室,河北 邢台 054000
Author(s):
SUN Jiawen12ZHAO Xiaoling2ZHANG Xiaochong2WANG Jitao2LIU Dengxiang2
1.Graduate School of Chengde Medical University,Chengde 067000,Hebei,China;2.Cancer Laboratory of Xingtai People’s Hospital,Xingtai 054000,Hebei,China
关键词:
可切除胃食管交界腺癌免疫治疗免疫检查点抑制剂
Keywords:
Resectable gastroesophageal junction adenocarcinomaImmunotherapyImmune checkpoint inhibitors
分类号:
R735
DOI:
10.3969/j.issn.1006-1959.2024.20.041
摘要:
胃食管交界腺癌发生于食管、胃的交界处,发病率高,现有的多学科治疗方法预后不佳。近年来,研究发现胃食管交界腺癌免疫检查点CTLA-4和PD-1/PD-L1的抑制剂,能够减少肿瘤细胞免疫逃逸,提高抗肿瘤作用,为患者带来更多生存获益。围手术期胃食管交界腺癌新辅助/辅助联合免疫疗法,可提高病理完全缓解率和手术成功率,能更大程度地降低术后肿瘤复发转移率,延长患者生存周期。本文就免疫治疗在可切除胃食管交界腺癌中的研究现状作一综述,以期为可切除胃食管交界腺癌的治疗及研究提供新思路。
Abstract:
Adenocarcinoma of the gastroesophageal junction occurs at the junction of the esophagus and the stomach, with a high incidence. The prognosis of the existing multidisciplinary treatment is poor. In recent years, studies have found that inhibitors of immune checkpoints CTLA-4 and PD-1/PD-L1 in gastroesophageal junction adenocarcinoma can reduce tumor cell immune escape, improve anti-tumor effects, and bring more survival benefits to patients. Perioperative neoadjuvant/adjuvant combined immunotherapy for gastroesophageal junction adenocarcinoma can improve the pathological complete remission rate and surgical success rate, reduce the postoperative tumor recurrence and metastasis rate to a greater extent, and prolong the survival period of patients. This article reviews the research status of immunotherapy in resectable gastroesophageal junction adenocarcinoma, in order to provide new ideas for the treatment and research of resectable gastroesophageal junction adenocarcinoma.

参考文献/References:

[1]Siewert JR,Stein HJ.Classification of adenocarcinoma of the oesophagogastric junction[J].Br J Surg,1998,85(11):1457-1459.[2]Sung H,Ferlay J,Siegel RL,et al.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J].CA Cancer J Clin,2021,71(3):209-249.[3]Al-Batran SE,Homann N,Pauligk C,et al.Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial[J].Lancet,2019,393(10184):1948-1957.[4]Rotte A,Jin JY,Lemaire V.Mechanistic overview of immune checkpoints to support the rational design of their combinations in cancer immunotherapy[J].Ann Oncol,2018,29(1):71-83.[5]Bang YJ,Cho JY,Kim YH,et al.Efficacy of Sequential Ipilimumab Monotherapy versus Best Supportive Care for Unresectable Locally Advanced/Metastatic Gastric or Gastroesophageal Junction Cancer[J].Clin Cancer Res,2017,23(19):5671-5678.[6]Janjigian YY,Bendell J,Calvo E,et al.CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer[J].J Clin Oncol,2018,36(28):2836-2844.[7]Tang Q,Chen Y,Li X,et al.The role of PD-1/PD-L1 and application of immune-checkpoint inhibitors in human cancers[J].Front Immunol,2022,13:964442.[8]Thompson ED,Zahurak M,Murphy A,et al.Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma[J].Gut,2017,66(5):794-801.[9]Shitara K,?魻zgüroglu M,Bang YJ,et al.Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial[J].Lancet,2018,392(10142):123-133.[10]Fuchs CS,?魻zgüroglu M,Bang YJ,et al.Pembrolizumab versus paclitaxel for previously treated PD-L1-positive advanced gastric or gastroesophageal junction cancer: 2-year update of the randomized phase 3 KEYNOTE-061 trial[J].Gastric Cancer,2022,25(1):197-206.[11]Chung HC,Kang YK,Chen Z,et al.Pembrolizumab versus paclitaxel for previously treated advanced gastric or gastroesophageal junction cancer (KEYNOTE-063): A randomized, open-label, phase 3 trial in Asian patients[J].Cancer,2022,128(5):995-1003.[12]Shitara K,Van Cutsem E,Bang YJ,et al.Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial[J].JAMA Oncol,2020,6(10):1571-1580.[13]Xu J,Jiang H,Pan Y,et al.Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer: The ORIENT-16 Randomized Clinical Trial[J].JAMA,2023,330(21):2064-2074.[14]Janjigian YY,Shitara K,Moehler M,et al.First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial[J].Lancet,2021,398(10294):27-40.[15]Kawazoe A,Yamaguchi K,Yasui H,et al.Safety and efficacy of pembrolizumab in combination with S-1 plus oxaliplatin as a first-line treatment in patients with advanced gastric/gastroesophageal junction cancer: Cohort 1 data from the KEYNOTE-659 phase IIb study[J].Eur J Cancer,2020,129:97-106.[16]Shah MA,Kennedy EB,Alarcon-Rozas AE,et al.Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline[J].J Clin Oncol,2023,41(7):1470-1491.[17]Grizzi G,Petrelli F,Di Bartolomeo M,et al.Preferred neoadjuvant therapy for gastric and gastroesophageal junction adenocarcinoma: a systematic review and network meta-analysis[J].Gastric Cancer,2022,25(5):982-987.[18]van Hagen P,Hulshof MC,van Lanschot JJ,et al.Preoperative chemoradiotherapy for esophageal or junctional cancer[J].N Engl J Med,2012,366(22):2074-2084.[19]Shapiro J,van Lanschot JJB,Hulshof MCCM,et al.Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial[J].Lancet Oncol,2015,16(9):1090-1098.[20]Weichselbaum RR,Liang H,Deng L,et al.Radiotherapy and immunotherapy: a beneficial liaison?[J].Nat Rev Clin Oncol,2017,14(6):365-379.[21]Tang Z,Wang Y,Liu D,et al.The Neo-PLANET phase II trial of neoadjuvant camrelizumab plus concurrent chemoradiotherapy in locally advanced adenocarcinoma of stomach or gastroesophageal junction[J].Nat Commun,2022,13(1):6807.[22]Shah MA,Almhanna K,Iqbal S,et al.Multicenter, randomized phase II study of neoadjuvant pembrolizumab plus chemotherapy and chemoradiotherapy in esophageal adenocarcinoma (EAC)[J].J Clin Oncol,2021,39(15_Suppl):4005.[23]Zhu M,Chen C,Foster NR,et al.Pembrolizumab in Combination with Neoadjuvant Chemoradiotherapy for Patients with Resectable Adenocarcinoma of the Gastroesophageal Junction[J].Clin Cancer Res,2022,28(14):3021-3031.[24]Kim R,An M,Lee H,et al.Early Tumor-Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer[J].Cancer Discov,2022,12(4):984-1001.[25]Jiang H,Yu X,Li N,et al.Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study[J].J Immunother Cancer,2022,10(3):e003635.[26]Yin Y,Lin Y,Yang M,et al.Neoadjuvant tislelizumab and tegafur/gimeracil/octeracil (S-1) plus oxaliplatin in patients with locally advanced gastric or gastroesophageal junction cancer: Early results of a phase 2, single-arm trial[J].Front Oncol,2022,12:959295.[27]Zhou M,Yang W,Xuan Y,et al.A study protocol of a randomized phase Ⅱ trial of perioperative chemoimmunotherapy verses perioperative chemoimmunotherapy plus preoperative chemoradiation for locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma: the NeoRacing study[J].BMC Cancer,2022,22(1):710.[28]Klevebro F,Johnsen G,Johnson E,et al.Morbidity and mortality after surgery for cancer of the oesophagus and gastro-oesophageal junction: A randomized clinical trial of neoadjuvant chemotherapy vs. neoadjuvant chemoradiation[J].Eur J Surg Oncol,2015,41(7):920-926.[29]Yoshida T,Ogura G,Tanabe M,et al.Clinicopathological features of PD-L1 protein expression, EBV positivity, and MSI status in patients with advanced gastric and esophagogastric junction adenocarcinoma in Japan[J].Cancer Biol Ther,2022,23(1):191-200.[30]Chao J,Fuchs CS,Shitara K,et al.Assessment of Pembrolizumab Therapy for the Treatment of Microsatellite Instability-High Gastric or Gastroesophageal Junction Cancer Among Patients in the KEYNOTE-059, KEYNOTE-061, and KEYNOTE-062 Clinical Trials[J].JAMA Oncol,2021,7(6):895-902.[31]André T,Tougeron D,Piessen G,et al.Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability-High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study[J].J Clin Oncol,2023,41(2):255-265.[32]Mokdad AA,Yopp AC,Polanco PM,et al.Adjuvant Chemotherapy vs Postoperative Observation Following Preoperative Chemoradiotherapy and Resection in Gastroesophageal Cancer: A Propensity Score-Matched Analysis[J].JAMA Oncol,2018,4(1):31-38.[33]Kelly RJ,Ajani JA,Kuzdzal J,et al.Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer[J].N Engl J Med,2021,384(13):1191-1203.[34]Mamdani H,Schneider B,Perkins SM,et al.A Phase II Trial of Adjuvant Durvalumab Following Trimodality Therapy for Locally Advanced Esophageal and Gastroesophageal Junction Adenocarcinoma: A Big Ten Cancer Research Consortium Study[J].Front Oncol,2021,11:736620.[35]Bratman SV,Yang SYC,Iafolla MAJ,et al.Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab[J].Nat Cancer,2020,1(9):873-881.[36]Park R,Da Silva LL,Saeed A.Immunotherapy Predictive Molecular Markers in Advanced Gastroesophageal Cancer: MSI and Beyond[J].Cancers (Basel),2021,13(7):1715.[37]Zhou KI,Peterson B,Serritella A,et al.Spatial and Temporal Heterogeneity of PD-L1 Expression and Tumor Mutational Burden in Gastroesophageal Adenocarcinoma at Baseline Diagnosis and after Chemotherapy[J].Clin Cancer Res,2020,26(24):6453-6463.

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更新日期/Last Update: 1900-01-01