[1]罗冬红.癌症疼痛患者接受盐酸吗啡缓释片治疗的效果及其安全性[J].医学信息,2024,37(21):103-106.[doi:10.3969/j.issn.1006-1959.2024.21.023]
　LUO Donghong.Efficacy and Safety of Morphine Hydrochloride Sustained-release Tablets in Patients with Cancer Pain[J].Journal of Medical Information,2024,37(21):103-106.[doi:10.3969/j.issn.1006-1959.2024.21.023]
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癌症疼痛患者接受盐酸吗啡缓释片治疗的效果及其安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年21期
页码:
103-106
栏目:
论著
出版日期:
2024-11-01

文章信息/Info

Title:
Efficacy and Safety of Morphine Hydrochloride Sustained-release Tablets in Patients with Cancer Pain
文章编号:
1006-1959（2024）21-0103-04
作者:
罗冬红
兴国县中医院西药房，江西 兴国 342400
Author(s):
LUO Donghong
Department of Western Pharmacy,Xingguo County Hospital of Traditional Chinese Medicine,Xingguo 342400,Jiangxi,China
关键词:
盐酸羟考酮缓释片; 盐酸吗啡缓释片; 癌症疼痛
Keywords:
Oxycodone hydrochloride; Morphine hydrochloride sustained-release tablets; Cancer pain
分类号:
R730.5
DOI:
10.3969/j.issn.1006-1959.2024.21.023
文献标志码:
A
摘要:
目的 分析盐酸吗啡缓释片治疗癌症疼痛患者的临床效果及其安全性。方法 选取2019年1月-2023年1月于兴国县中医院治疗的70例癌症疼痛患者为研究对象，按随机数字表法分为对照组和研究组，各35例。对照组采用盐酸羟考酮缓释片治疗，研究组采用盐酸吗啡缓释片治疗，比较两组疼痛缓解情况、ECOG评分、疼痛评分、生活质量（躯体、心理、情感和社会职能）、不良反应发生率。结果 研究组总缓解率（97.14%）高于对照组（77.14）（P＜0.05）；两组治疗后ECOG评分低于治疗前，且研究组ECOG评分低于对照组（P＜0.05）；研究组治疗24 h、72 h、1周和2周后的NRS评分均低于对照组（P＜0.05）；两组治疗后生活质量评分高于治疗前，且研究组生活质量评分高于对照组（P＜0.05）；研究组不良反应发生率（8.57%）低于对照组（40.00%）（P＜0.05）。结论 对癌症疼痛患者采用盐酸吗啡缓释片进行治疗，可有效提高治疗效果，减轻患者疼痛，提高患者生活质量以及体能状况，且不良反应少，安全性高。
Abstract:
Objective To analyze the clinical effect and safety of morphine hydrochloride sustained-release tablets in the treatment of patients with cancer pain.Methods A total of 70 patients with cancer pain treated in Xingguo County Hospital of Traditional Chinese Medicine from January 2019 to January 2023 were selected as the research objects, and they were divided into control group and study group according to the random number table method, with 35 patients in each group. The control group was treated with oxycodone hydrochloride, and the study group was treated with morphine hydrochloride sustained-release tablets. The pain relief, ECOG score, pain score, quality of life (physical, psychological, emotional and social functions) and incidence of adverse reactions were compared between the two groups.Results The total remission rate of the study group (97.14%) was higher than that of the control group (77.14%) (P<0.05). The ECOG score of the two groups after treatment was lower than that before treatment, and the ECOG score of the study group was lower than that of the control group (P<0.05). The NRS score of the study group at 24 h, 72 h, 1 week and 2 weeks after treatment was lower than that of the control group (P<0.05). The quality of life score of the two groups after treatment was higher than that before treatment, and the quality of life score of the study group was higher than that of the control group (P<0.05). The incidence of adverse reactions in the study group (8.57%) was lower than that in the control group (40.00%) (P<0.05).Conclusion For patients with cancer pain, morphine hydrochloride sustained-release tablets can effectively improve the therapeutic effect, relieve pain, improve the quality of life and physical condition of patients, and have fewer adverse reactions and high safety.

参考文献/References:

[1]王国平,李霞,何朗,等.奥氮平联合盐酸吗啡缓释片治疗癌性疼痛的疗效和安全性分析[J].东南国防医药,2020,22(6):622-626.[2]崔小天,高宏,潘玉真,等.中药止痛贴与吗啡联合应用于癌症疼痛的镇痛效果及安全性[J].现代生物医学进展,2018,18(20):3883-3886.[3]Inoue S,Saito Y,Tsuneto S,et al.A randomized, double-blind, non-inferiority study of hydromorphone hydrochloride immediate-release tablets versus oxycodone hydrochloride immediate-release powder for cancer pain: efficacy and safety in Japanese cancer patients[J].Jpn J Clin Oncol,2018,48(6):542-547.[4]Robert M,Jouanjus E,Khouri C,et al.The opioid epidemic: A worldwide exploratory study using the WHO pharmacovigilance database[J].Addiction,2023,118(4):771-775.[5]周颖,向敏,王汝晋.盐酸吗啡缓释片联合普瑞巴林治疗癌性神经性疼痛的临床疗效[J].现代肿瘤医学,2019,27(7):1200-1204.[6]张志红,陈日新,朱州,等.盐酸吗啡缓释片和盐酸羟考酮缓释片治疗肝功能受损患者癌痛的疗效及安全性[J].重庆医学,2021,50(7):1174-1177.[7]冯婷,张静月,孙东光,等.普瑞巴林联合盐酸吗啡缓释片治疗前列腺癌神经病理性癌痛的临床疗效研究[J].标记免疫分析与临床,2023,30(5):753-757.[8]王鹏远,董雪茹,尚娜娜,等.盐酸羟考酮缓释片与盐酸吗啡缓释片分别联合盐酸吗啡针治疗重度癌痛的疗效对比[J].重庆医学,2023,52(10):1505-1509,1514.[9]赵雅玮,许广丽,梁靓,等.复方苦参注射液联合盐酸吗啡缓释片治疗中重度癌痛的临床疗效研究[J].药学与临床研究,2019,27(1):43-45.[10]缪继东,王伟.盐酸吗啡缓释片联合复方苦参注射液治疗中重度癌痛患者临床观察[J].辽宁中医杂志,2023,50(3):123-126.[11]刘艳丽,王静,王文星,等.乌龙消瘤止痛方治疗癌性疼痛的疗效及机制的临床研究[J].现代肿瘤医学,2019,27(10):1789-1792.[12]张国平,赵利平,韩光明,等.盐酸羟考酮缓释片治疗中重度癌痛的效果及对患者免疫功能的影响[J].中国药物应用与监测,2021,18(2):71-73,78.[13]张敏,吴月月,李崇慧,等.复方苦参注射液联合盐酸羟考酮缓释片治疗消化系统中重度慢性癌性疼痛的疗效观察[J].中国医院用药评价与分析,2023,23(2):154-157.[14]白晓博,魏晓辉,贾本治.盐酸羟考酮缓释片联合SGB对非小细胞肺癌中重度癌痛患者的镇痛效果[J].海南医学,2023,34(9):1263-1267.[15]李正凯,阮雁捷,郭冠军,等.盐酸羟考酮在大鼠胃癌根治术中的超前镇痛效果评价及对应激反应的影响[J].实用癌症杂志,2022,37(12):1920-1925.[16]卢小雪,王晓红,赵勇.盐酸羟考酮缓释片联合盐酸曲唑酮片治疗癌性疼痛的疗效观察[J].老年医学与保健,2023,29(3):619-621.[17]崔璨,刘影,康长娟.盐酸羟考酮缓释片对急诊癌痛患者疼痛的影响及安全性[J].癌症进展,2022,20(6):585-588.[18]王苗级,王磊.丙泊酚联合盐酸羟考酮注射液和瑞芬太尼在老年肝癌患者行射频消融术中的应用[J].中国老年学杂志,2022,42(4):856-860.[19]聂彬,迟晓慧,谭娟.盐酸羟考酮注射液在舌癌根治术留置气管导管患者术后镇痛中的应用效果[J].临床口腔医学杂志,2022,38(1):26-29.[20]王雨,董明.天蟾胶囊联合盐酸羟考酮缓释片治疗晚期胃癌癌性疼痛的临床疗效及对生活质量的影响[J].中国医院用药评价与分析,2022,22(2):172-175.

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更新日期/Last Update: 1900-01-01