[1]何六六,梅秋英,徐奕胜,等.自体富血小板血浆宫腔灌注对薄型子宫患者的子宫内膜厚度、血流动力学及排卵率的影响[J].医学信息,2024,37(22):30-33.[doi:10.3969/j.issn.1006-1959.2024.22.007]
　HE Liuliu,MEI Qiuying,XU Yisheng,et al.Effect of Autologous Platelet-rich Plasma Intrauterine Perfusion on Endometrial Thickness, Hemodynamics and Ovulation Rate in Patients with Thin Uterus[J].Journal of Medical Information,2024,37(22):30-33.[doi:10.3969/j.issn.1006-1959.2024.22.007]
点击复制

自体富血小板血浆宫腔灌注对薄型子宫患者的子宫内膜厚度、血流动力学及排卵率的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年22期
页码:
30-33
栏目:
论著
出版日期:
2024-11-15

文章信息/Info

Title:
Effect of Autologous Platelet-rich Plasma Intrauterine Perfusion on Endometrial Thickness, Hemodynamics and Ovulation Rate in Patients with Thin Uterus
文章编号:
1006-1959（2024）22-0030-04
作者:
何六六; 梅秋英; 徐奕胜; 李秋平
赣南医学院第二附属医院检验科，江西 信丰 341600
Author(s):
HE Liuliu; MEI Qiuying; XU Yisheng; LI Qiuping
Laboratory Department of the Second Affiliated Hospital of Gannan Medical University,Xinfeng 341600,Jiangxi,China
关键词:
自体富血小板血浆; 宫腔灌注; 薄型子宫; 子宫内膜厚度; 排卵率
Keywords:
Autologous platelet-rich plasma; Uterine perfusion; Thin uterus; Endometrial thickness; Ovulation rate
分类号:
R711.6
DOI:
10.3969/j.issn.1006-1959.2024.22.007
摘要:
目的 研究自体富血小板血浆宫腔灌注对薄型子宫患者的子宫内膜厚度、血流动力学及排卵率的影响。方法 选取2022年4月-2023年4月在我院行冻融胚胎移植的薄型子宫内膜患者60例为研究对象，采用随机数字表法分为对照组和观察组，各组30例，对照组采用生理盐水宫腔灌注，观察组采用富血小板血浆（PRP）宫腔灌注。比较两组子宫内膜厚度、血流动力学[血管阻力指数（RI）、搏动指数（PI）、收缩末期/舒张末期血流速度比值（S/D）]指标、优势卵泡发育率、排卵率及不良反应发生率。结果 观察组子宫内膜厚度大于对照组（P＜0.05）；两组RI、PI、S/D均低于治疗前，且观察组低于对照组（P＜0.05）；观察组优势卵泡发育率、排卵率均高于对照组（P＜0.05）；观察组不良反应发生率（10.00%）与对照组（6.67%）比较，差异无统计学意义（P＞0.05）。结论 自体富血小板血浆宫腔灌注对薄型子宫患者的子宫内膜厚度、血流动力学及排卵率均具有积极的影响，可增加子宫内膜厚度，提高排卵率，改善子宫血流动力学，且无显著不良反应，是一种可行、安全的治疗方法。
Abstract:
Objective To study the effect of intrauterine infusion of autologous platelet-rich plasma on endometrial thickness, hemodynamics and ovulation rate in patients with thin uterus.Methods A total of 60 patients with thin endometrium who underwent frozen-thawed embryo transfer in our hospital from April 2022 to April 2023 were selected as the research objects. They were divided into control group and observation group by random number table method, with 30 patients in each group. The control group was treated with normal saline intrauterine perfusion, and the observation group was treated with platelet-rich plasma (PRP) intrauterine perfusion. The endometrial thickness, hemodynamics [vascular resistance index (RI), pulsatility index (PI), end-systolic/end-diastolic blood flow velocity ratio (S/D)], dominant follicle development rate, ovulation rate and incidence of adverse reactions were compared between the two groups.Results The endometrial thickness of the observation group was greater than that of the control group (P<0.05). RI, PI and S/D in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The dominant follicle development rate and ovulation rate in the observation group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (10.00%) and the control group (6.67%) (P>0.05).Conclusion Autologous platelet-rich plasma intrauterine perfusion has a positive effect on endometrial thickness, hemodynamics and ovulation rate in patients with thin uterus. Meanwhile, it can increase endometrial thickness, improve ovulation rate and uterine hemodynamics, and has no significant incidence of adverse reactions. It is a feasible and safe treatment method.

参考文献/References:

[1]Kim JH,Park M,Paek JY,et al.Intrauterine infusion of human platelet-rich plasma improves endometrial regener ation and pregnancy outcomes in a murine model of ash erman’s syndrome[J].Front Physiol,2020,11:105.[2]王巍,马海兰.自体血小板富集血浆宫腔灌注在反复种植失败患者中的应用研究[J].微创医学,2018,13:497-499.[3]汪佳,葛红山,陈新萍,等.重组人粒细胞集落刺激因子灌注改善子宫内膜容受性的临床研究[J].中国处方药,2019,17:74-75.[4]Zhang SW,Chang QY,Li PP,et al.Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model[J].Nanoscale,2021,13(15):7334-7347.[5]黄艳,曾诚,吴培莉,等.异位子宫内膜间质细胞中LIF及IL-6对VEGF的调控作用[J].中华妇产科杂志,2019,54(5):324-329. [6]邵小光,魏晗,房圣梓.辅助生殖技术中薄型子宫内膜的诊断标准与临床处理[J].中国实用妇科与产科杂志,2020,36(6):496-500.[7]屠世炯,李洁.子宫内膜容受性预测体外受精胚胎移植成功率的价值[J].中国妇幼保健,2022,37(4):668-670.[8]赵蕾,陈志芳,杜蓉,等.月经血子宫内膜间充质干细胞向子宫内膜上皮细胞分化的实验研究[J].中国妇产科临床杂志,2020,21(5):470-473.[9]单桂秋,施琳颖,李艳辉,等.自体富血小板血浆制备技术专家共识[J].中国输血杂志,2021,34(7):677-683.[10]郑娟,谈勇.定坤丹联合戊酸雌二醇对肾阳虚薄型子宫内膜大鼠Wnt/β-catenin信号通路的影响[J].四川大学学报:医学版,2021,52(2):235-240.[11]钟丽珍,艾丹,许婷,等.定坤丹治疗肾阳虚证薄型子宫内膜不孕症的临床研究[J].医学理论与实践,2022,35(16):2790-2792.[12]赵芳,石占荣,张艳萍,等.子宫内膜厚度和移植胚胎类型对冻融胚胎移植周期临床结局的影响[J].生殖医学杂志,2023,32(1):125-129.[13]成慧,刘科鹏,刘媛,等.富血小板血浆对薄型子宫内膜患者冻融周期妊娠结局的影响[J].现代妇产科进展,2020,29(6):450-453.[14]唐宁,李泽武,王靖雯,等.富血小板血浆宫腔灌注对薄型子宫内膜患者冻融胚胎移植妊娠结局的影响[J].生殖医学杂志,2023,32(11):1630-1633.[15]王晓寒,刘玲,牟善茂,等.富血小板血浆治疗小鼠薄型子宫内膜的效果及机制研究[J].中国妇产科临床杂志,2023,24(7):401-403.[16]Li W,Cao Z,Yu X,et al.Effect of growth hormone on thin endometrium via intrauterine infusion[J].Ann Transl Med,2021,9(16):1325.[17]向富森,孙甫,刘丽莹,等.生长激素宫腔灌注联合激素替代周期在薄型子宫内膜患者冻融胚胎移植效果分析[J].中国计划生育学杂志,2022,30(10):2299-2301.[18]魏珑珑,张翠莲.两种非依赖内源性卵巢周期的内膜准备方案对薄型子宫内膜冻融胚胎移植患者妊娠结局的影响研究[J].中国全科医学,2022,25(3):269-274.[19]张玉菡,苏琼,伍琼芳,等.宫腔灌注人粒细胞巨噬细胞刺激因子凝胶对薄型子宫内膜FET结局的影响[J].宜春学院学报,2023,25(9):1770-1772.

相似文献/References:

[1]马荣花,王莉云,沈源春,等.胚胎移植前宫腔内灌注hCG对FET反复着床失败患者 妊娠结局的影响[J].医学信息,2018,31(13):81.[doi:10.3969/j.issn.1006-1959.2018.13.023]
　MA Rong-hua,WANG Li-yun,SHEN Yuan-chun,et al.Effect of Intrauterine Perfusion of hCG before Embryo Transfer on Pregnancy Outcome in Patients with FET Repeated Implantation Failure[J].Journal of Medical Information,2018,31(22):81.[doi:10.3969/j.issn.1006-1959.2018.13.023]
[2]邓智心,袁 莹,邹志玲,等.不孕症患者慢性子宫内膜炎的诊疗[J].医学信息,2021,34(11):31.[doi:10.3969/j.issn.1006-1959.2021.11.010]
　DENG Zhi-xin,YUAN Ying,ZOU Zhi-ling,et al.Diagnosis and Treatment of Chronic Endometritis in Infertility Patients[J].Journal of Medical Information,2021,34(22):31.[doi:10.3969/j.issn.1006-1959.2021.11.010]

更新日期/Last Update: 1900-01-01