[1]范礼英,熊喜悦,冯彬彬,等.肠道菌群与早产儿坏死性小肠结肠炎发生发展的关系[J].医学信息,2025,38(02):88-91.[doi:10.3969/j.issn.1006-1959.2025.02.015]
 FAN Liying,XIONG Xiyue,FENG Binbin,et al.Relationship Between Intestinal Flora and the Occurrence and Development of Necrotizing Enterocolitis in Premature Infants[J].Journal of Medical Information,2025,38(02):88-91.[doi:10.3969/j.issn.1006-1959.2025.02.015]
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肠道菌群与早产儿坏死性小肠结肠炎发生发展的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年02期
页码:
88-91
栏目:
论著
出版日期:
2025-01-15

文章信息/Info

Title:
Relationship Between Intestinal Flora and the Occurrence and Development of Necrotizing Enterocolitis in Premature Infants
文章编号:
1006-1959(2025)02-0088-04
作者:
范礼英熊喜悦冯彬彬李素萍龚 谨汪 倩潘 千
湖南省妇幼保健院新生儿二科,湖南 长沙 410008
Author(s):
FAN Liying XIONG Xiyue FENG Binbin LI Suping GONG Jin WANG Qian PAN Qian
The Second Department of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, China
关键词:
婴儿早产小肠结肠炎坏死性粪便高通量核苷酸测序
Keywords:
Infant Premature Enterocolitis Necrotizing Feces High throughput nucleotide sequencing
分类号:
R722.1
DOI:
10.3969/j.issn.1006-1959.2025.02.015
文献标志码:
A
摘要:
目的 应用16SrDNA 测序技术分析早产儿坏死性小肠结肠炎(NEC)肠道菌群变化情况。方法 以2021年1月-2023年7月在湖南省妇幼保健院出生、出生胎龄<32周、出生后24 h内住院、住院过程并发NEC的早产儿20例作为研究对象,于发病后2 h内收集NEC组和匹配对照组20例出生胎龄<32周、出生后24 h内早产儿粪便标本,采用高通量测序技术对两组患儿肠道菌群进行分析。结果 两组早产儿及其母亲的一般情况比较,差异均无统计学意义(P>0.05);但NEC组肠道菌群不动杆菌属、假单胞菌属高于对照组(P<0.05);Alpha多样性分析显示,NEC组Shannon指数和Simpson指数高于对照组(P<0.05)。结论 早产儿肠道菌群不动杆菌属、假单胞菌属增多可能与NEC的发生有关。
Abstract:
Objective To analyze the changes of intestinal flora in premature infants with necrotizing enterocolitis (NEC) by 16SrDNA sequencing. Methods A total of 20 premature infants born in Hunan Maternal and Child Health Care Hospital from January 2021 to July 2023, with gestational age <32 weeks, hospitalization within 24 h after birth, and complications of NEC during hospitalization were selected as the study objects. Within 2 hours after the onset of the disease, fecal samples of 20 premature infants in the NEC group and matched control group with gestational age <32 weeks and within 24 h after birth were collected, and the intestinal flora of the children in the two groups was analyzed by high-throughput sequencing technology. Results There was no significant difference in the general conditions of premature infants and their mothers between the two groups (P>0.05). However, the intestinal flora of Acinetobacter and Pseudomonas in the NEC group was higher than that in the control group (P<0.05). Alpha diversity analysis showed that the Shannon index and Simpson index of the NEC group were higher than those of the control group (P<0.05). Conclusion The increase of Acinetobacter and Pseudomonas in the intestinal flora of premature infants may be related to the occurrence of NEC.

参考文献/References:

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更新日期/Last Update: 1900-01-01