[1]卢 琪,尹富生,兰 凯.PI3K/AKT/mTOR通路与胰腺癌发生发展及治疗的研究[J].医学信息,2025,38(02):184-187.[doi:10.3969/j.issn.1006-1959.2025.02.037]
 LU Qi,YIN Fusheng,LAN Kai.Role of PI3K/AKT/mTOR Pathway in the Development and Treatment of Pancreatic Cancer[J].Journal of Medical Information,2025,38(02):184-187.[doi:10.3969/j.issn.1006-1959.2025.02.037]
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PI3K/AKT/mTOR通路与胰腺癌发生发展及治疗的研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年02期
页码:
184-187
栏目:
综述
出版日期:
2025-01-15

文章信息/Info

Title:
Role of PI3K/AKT/mTOR Pathway in the Development and Treatment of Pancreatic Cancer
文章编号:
1006-1959(2025)02-0184-04
作者:
卢 琪尹富生兰 凯
西安医学院临床医学院,陕西 西安 710000
Author(s):
LU Qi YIN Fusheng LAN Kai
Clinical Medical College of Xi′an Medical University, Xi′an 710000, Shaanxi, China
关键词:
胰腺癌PI3K/AKT/mTOR信号通路抑制剂
Keywords:
Pancreatic cancer PI3K/AKT/mTOR Signal pathway Inhibitor
分类号:
R285.5
DOI:
10.3969/j.issn.1006-1959.2025.02.037
文献标志码:
A
摘要:
胰腺癌(PC)是一种致命性高的恶性肿瘤,患病率死亡率逐年上升。除了常规手术治疗外,靶向治疗前景广阔。磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(PKB/AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)等信号通路调控了肿瘤细胞生长、增殖凋亡、细胞周期、侵袭转移等生物行为。而胰腺癌细胞中的PI3K/AKT/mTOR通路往往会被过度的激活,并影响胰腺癌的进展。基于此,本文对PI3K/AKT/mTOR信号转导通路的分子组成及其激活过程、该通路与胰腺癌的作用机制,以及靶向该通路抑制剂在胰腺癌中的研究进展进行综述。
Abstract:
Pancreatic cancer (PC) is a fatal malignant tumor, and its morbidity and mortality are increasing year by year. In addition to conventional surgical treatment, targeted therapy has broad prospects. Phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) and other signaling pathways regulate the growth, proliferation, apoptosis, cell cycle, invasion and metastasis of tumor cells. The PI3K/AKT/mTOR pathway in pancreatic cancer cells is often over-activated and affects the progression of pancreatic cancer. Based on this, this paper reviews the molecular composition and activation process of PI3K/AKT/mTOR signal transduction pathway, the mechanism of this pathway and pancreatic cancer, and the research progress of inhibitors targeting this pathway in pancreatic cancer.

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更新日期/Last Update: 1900-01-01