[1]杨 璈,钟世林.法尼醇X受体对血糖代谢的调控作用[J].医学信息,2025,38(06):168-172.[doi:10.3969/j.issn.1006-1959.2025.06.032]
 YANG Ao,ZHONG Shilin.Regulation of Farnesoid X Receptor on Blood Glucose Metabolism[J].Journal of Medical Information,2025,38(06):168-172.[doi:10.3969/j.issn.1006-1959.2025.06.032]
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法尼醇X受体对血糖代谢的调控作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年06期
页码:
168-172
栏目:
综述
出版日期:
2025-03-15

文章信息/Info

Title:
Regulation of Farnesoid X Receptor on Blood Glucose Metabolism
文章编号:
1006-1959(2025)06-0168-05
作者:
杨 璈1234钟世林1234
1.广东医科大学第一临床医学院,广东 湛江 524023;2.北京大学深圳医院妇产中心,广东 深圳 518036;3.深圳北京大学香港科技大学医学中心妇产科学研究所,广东 深圳 518036;4.深圳市女性重大疾病早期诊断技术重点实验室,广东 深圳 518036
Author(s):
YANG Ao1234 ZHONG Shilin1234
1.The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524023, Guangdong, China; 2.Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong, China; 3.Institute of Obstetrics and Gynecology, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, Guangdong, China; 4.Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Shenzhen 518036, Guangdong, China
关键词:
法尼醇X受体血糖代谢妊娠期糖尿病2型糖尿病胆汁酸
Keywords:
Farnesol X receptor Blood glucose metabolism Gestational diabetes mellitus Type 2 diabetes mellitus Bile acid
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2025.06.032
文献标志码:
A
摘要:
法尼醇X受体(FXR)是一种胆汁酸受体,参与了胆汁酸的合成、运输、重吸收和调节糖代谢等重要过程。特别是在糖代谢方面,肝脏中的FXR有调节糖异生和糖原合成的作用,肠道中的FXR可以通过多种途径调节肠道吸收和转运葡萄糖。研究表明,FXR有可能成为控制糖尿病的一个靶点。然而,关于妊娠期FXR如何调节血糖仍需要进一步探讨。考虑到肠道菌群也可能参与FXR调节糖代谢的过程,需要进一步探讨肠道菌群-FXR通路在妊娠期血糖代谢调节中的作用。本文主要从肝脏或肠道中FXR对血糖代谢的调控以及对妊娠期血糖代谢方面相关研究进行综述,旨在为进一步探索FXR对妊娠期血糖代谢功能影响及机制提供参考。
Abstract:
The farnesoid X receptor (FXR) is a bile acid receptor that plays a key role in the synthesis, transport, reabsorption of bile acids, and the regulation of glucose metabolism. In the liver, FXR regulates gluconeogenesis and glycogen synthesis, making it crucial for glucose metabolism. Moreover, in the gut, FXR is involved in regulating intestinal glucose absorption and transport through various pathways. These findings suggest that FXR could potentially be targeted for controlling diabetes mellitus. However, the specific role of the FXR pathway in glucose regulation during pregnancy needs further clarification. Considering that intestinal flora may also be involved in the process of FXR regulating glucose metabolism, it is necessary to further explore the role of intestinal flora-FXR pathway in the regulation of blood glucose metabolism during pregnancy. This article mainly reviews the regulation of FXR on blood glucose metabolism in the liver or intestine and the related research on blood glucose metabolism during pregnancy, aiming to provide a reference for further exploring the effect and mechanism of FXR on blood glucose metabolism during pregnancy.

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更新日期/Last Update: 1900-01-01