[1]傅联鹏.泌尿系结石合并感染的临床病原菌检测分析[J].医学信息,2025,38(16):148-151.[doi:10.3969/j.issn.1006-1959.2025.16.031]
　FU Lianpeng.Detection and Analysis of Clinical Pathogenic Bacteria in Urinary Calculi Complicated with Infection[J].Journal of Medical Information,2025,38(16):148-151.[doi:10.3969/j.issn.1006-1959.2025.16.031]
点击复制

泌尿系结石合并感染的临床病原菌检测分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年16期
页码:
148-151
栏目:
诊疗技术
出版日期:
2025-08-15

文章信息/Info

Title:
Detection and Analysis of Clinical Pathogenic Bacteria in Urinary Calculi Complicated with Infection
文章编号:
1006-1959（2025）16-0148-04
作者:
傅联鹏
信丰县人民医院医学检验科，江西 信丰 341600
Author(s):
FU Lianpeng
Department of Medical Laboratory, Xinfeng County People’s Hospital, Xinfeng 341600, Jiangxi, China
关键词:
泌尿系结石; 感染; 病原菌
Keywords:
Urinary calculi;  Infection;  Pathogenic bacteria
分类号:
R691
DOI:
10.3969/j.issn.1006-1959.2025.16.031
文献标志码:
A
摘要:
目的 研究泌尿系结石合并感染患者临床病原菌检测结果。方法 选取2021年1月-2023年12月我院诊治的321例泌尿系结石合并感染患者为研究对象，均进行中段尿培养，观察病原菌检测结果，分析泌尿系结石合并感染病原菌种类、不同临床特征患者病原菌种类以及主要病原菌耐药性。结果 321例泌尿系结石合并感染患者共培养出321株，病原菌以革兰阴性杆菌为主，检出193株，占60.12%；2021-2023年期间病原菌检出率比较，差异无统计学意义（P＞0.05）。不同直径、部位泌尿系结石合并感染患者病原菌种类比较，差异无统计学意义（P＞0.05），而复发泌尿系结石合并感染患者病原菌中革兰阴性菌占比高于无泌尿系结石合并感染患者（P＜0.05）。大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌对莫西沙星、环丙沙星、头孢唑林、头孢呋辛、哌拉西林、氨苄西林、替卡西林、复方磺胺甲唑的耐药率高于亚胺培南、阿莫西林-克拉维酸钾、阿莫西林（P＜0.05）；粪肠球菌、屎肠球菌对苯唑西林、青霉素、氨苄西林、庆大霉素的耐药率高于万古霉素、左氧氟沙星、莫西沙星（P＜0.05）。结论 泌尿系结石合并感染患者病原菌分布具有一定的特点，主要以革兰阴性菌为主，临床应避免经验性用药，依据病原菌检测和药敏试验结果科学合理选择药物进行有效治疗。
Abstract:
Objective To study the detection results of clinical pathogens in patients with urinary calculi complicated with infection. Methods A total of 321 patients with urinary calculi complicated with infection diagnosed and treated in our hospital from January 2021 to December 2023 were selected as the research objects. All patients underwent midstream urine culture. The results of pathogen detection were observed. The types of pathogenic bacteria in urinary calculi complicated with infection, the types of pathogenic bacteria in patients with different clinical characteristics and the drug resistance of main pathogenic bacteria were analyzed. Results Totally 321 strains were cultured from 321 patients with urinary calculi complicated with infection, gram-negative bacilli were the main pathogens (193 strains), accounting for 60.12%. There was no significant difference in the detection rate of pathogenic bacteria during 2021-2023 (P>0.05). There was no significant difference in the types of pathogenic bacteria in patients with different diameters and sites of urinary calculi complicated with infection (P>0.05), while the proportion of gram-negative bacteria in patients with recurrent urinary calculi complicated with infection was higher than that in patients without urinary calculi complicated with infection (P<0.05). The resistance rates of Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae to moxifloxacin, ciprofloxacin, cefazolin, cefuroxime, piperacillin, ampicillin, ticarcillin and compound sulfamethoxazole were higher than those of imipenem, amoxicillin-clavulanate potassium and amoxicillin (P<0.05). The resistance rates of Enterococcus faecalis and Enterococcus faecium to oxacillin, penicillin, ampicillin and gentamicin were higher than those of vancomycin, levofloxacin and moxifloxacin (P<0.05). Conclusion The distribution of pathogenic bacteria in patients with urinary calculi complicated with infection has certain characteristics, mainly gram-negative bacteria. Clinically, empirical medication should be avoided, and drugs should be selected scientifically and reasonably according to the results of pathogenic bacteria detection and drug sensitivity test for effective treatment.

参考文献/References:

[1]Zhang Z,Wang X,Chen D,et al.Minimally invasive management of acute ureteral obstruction and severe infection caused by upper urinary tract calculi[J].J Xray Sci Technol,2020,28(1):125-135.[2]刘卓伟.泌尿系结石患者急性泌尿系感染与肾功能不全、肾积水的关联性及临床意义探讨[J].中国研究型医院,2019,6(2):48-53.[3]吴石,朱从武,王忠,等.上尿路结石患者内镜碎石术后泌尿系统感染的临床分析[J].吉林医学,2017,38(11):2142-2143.[4]罗湘蓉,郑朋玉,袁军,等.泌尿道结石患者尿道感染病原菌分布及耐药性分析[J].中国医科大学学报,2015,44(11):1031-1034.[5]李航,罗俊华,毛向明,等.泌尿道结石合并感染患者尿液标本中病原菌分布及耐药性分析[J].中国卫生工程学,2017,16(2):245-246.[6]李本根,李霞,娄金波,等.泌尿系统结石合并感染患者尿液标本病原菌分布及耐药性分析[J].中华医院感染学杂志,2018,2(21):245-246.[7]Itami Y,Miyake M,Owari T,et al.Optimal timing of ureteroscopic lithotripsy after the initial drainage treatment and risk factors for postoperative febrile urinary tract infection in patients with obstructive pyelonephritis: a retrospective study[J].BMC Urol,2021,21(1):10.[8]丁孟德,陈中朝,王林俊,等.胆道结石术后医院感染病原菌及相关影响因素分析[J].中华医院感染学杂志,2018,28(1):84-87.[9]连学雄,李锋,赵仕佳,等.复杂性肾结石患者经皮肾镜碎石术后并发尿路感染危险因素分析 [J]. 微创泌尿外科杂志,2021,10(4):221-225.[10]Wallace B,Chmiel JA,Al KF,et al.The Role of Urinary Modulators in the Development of Infectious Kidney Stones[J].J Endourol,2023,37(3):358-366.[11]王焕,崔凯,郭利芹,等.住院肾病患者尿路感染肠球菌的菌型分布及耐药性分析[J].中国病原生物学杂志,2022,17(1):103-105.[12]孙金山,陈朝英,李静.北京地区单中心儿童泌尿道感染病原菌的动态变迁[J].中华实用儿科临床杂志,2020,35(17):1325-1328.[13]钟为群.尿八联检验联合定量尿培养在尿路感染诊断中的应用价值[J].实用临床医药杂志,2020,24(5):101-103.[14]张钻兵,李美珍,邱琳.某院2018年-2019年泌尿系结石患者尿路感染病原菌的分布及其耐药性分析[J].抗感染药学,2021,18(7):1018-1021.[15]陈薇,向锁玉,曹阳.泌尿外科患者输尿管支架置入术后发生尿路感染的危险因素及病原菌分析[J].中华临床感染病杂志,2019,12(5):344-349.[16]陈中举,田磊,杨为民,等. 2016～2018年泌尿外科患者尿路感染病原菌分布及耐药性分析[J].临床泌尿外科杂志,2020,35(2):103-107.[17]Skolarikos A,Somani B,Neisius A,et al.Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: An EAU Guidelines Update[J].Eur Urol,2024,86(4):343-363.[18]王河生,吴雯,郑爱桦.743株尿路感染患者病原菌的分布及其耐药性分析[J].抗感染药学,2019,16(7):1143-1146.[19]冶生芳,王晋龙,德吉卓嘎.某院尿路结石合并感染的细菌谱变迁及药敏特点[J].检验医学与临床,2019,16(3):397-399.[20]杨俊,李淦洪,李乾伟,等.泌尿系结石患者尿路感染病原菌分布及耐药性特点分析[J].吉林医学,2019,40(7):1482-1483.

相似文献/References:

[1]韩 梅,吴 寒.我国弓形虫病研究进展[J].医学信息,2018,31(02):33.[doi:10.3969/j.issn.1006-1959.2018.02.012]
　HAN Mei,WU Han.Research Advances on Toxoplasmosis in China[J].Journal of Medical Information,2018,31(16):33.[doi:10.3969/j.issn.1006-1959.2018.02.012]
[2]周 琳,陈丽琴,李伟杰,等.某儿童医院轮状病毒感染的现状分析[J].医学信息,2018,31(02):114.[doi:10.3969/j.issn.1006-1959.2018.02.041]
　ZHOU Lin,CHEN Li-qin,LI Wei-jie,et al.The Status Quo Analysis of Rotavirus Infection in a Children's Hospital[J].Journal of Medical Information,2018,31(16):114.[doi:10.3969/j.issn.1006-1959.2018.02.041]
[3]陈世秋.循证护理在降低剖宫产术后感染及改善 产妇生存质量中的效果研究[J].医学信息,2018,31(09):169.[doi:10.3969/j.issn.1006-1959.2018.09.056]
　CHEN Shi-qiu.Effect of Evidence-based Nursing on Reducing Infection after Cesarean Section and Improving Maternal Quality of Life[J].Journal of Medical Information,2018,31(16):169.[doi:10.3969/j.issn.1006-1959.2018.09.056]
[4]段 巍.1例晚期胃癌化疗并发嗜血细胞综合征患者的护理[J].医学信息,2018,31(10):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
　DUAN Wei.Nursing Care of a Case of Advanced Gastric Carcinoma with Hemophagocytic Syndrome after Chemotherapy[J].Journal of Medical Information,2018,31(16):181.[doi:10.3969/j.issn.1006-1959.2018.10.063]
[5]廖 敏,雷 宏,陈淑萍.赣州市章贡区2015~2016年儿童肠道寄生虫感染情况分析[J].医学信息,2018,31(15):110.[doi:10.3969/j.issn.1006-1959.2018.15.034]
　LIAO Min,LEI Hong,CHEN Shu-ping.Analysis of Intestinal Parasite Infection in Children From 2015 to 2016 in Zhanggong District of Ganzhou City[J].Journal of Medical Information,2018,31(16):110.[doi:10.3969/j.issn.1006-1959.2018.15.034]
[6]胡 进,王春霞.预防泌尿系结石复发的健康教育研究[J].医学信息,2018,31(21):44.[doi:10.3969/j.issn.1006-1959.2018.21.013]
　HU Jin,WANG Chun-xia.Health Education Progress in Preventing Recurrence of Urolithiasis[J].Journal of Medical Information,2018,31(16):44.[doi:10.3969/j.issn.1006-1959.2018.21.013]
[7]王 蕊,陈金萍.2016~2017年脊柱手术预防用药及术后感染情况分析[J].医学信息,2018,31(24):112.[doi:10.3969/j.issn.1006-1959.2018.24.032]
　WANG Rui,CHEN Jin-ping.Analysis of Orophylactic Medication and Postoperative Infection in Spinal Surgery from 2016 to 2017[J].Journal of Medical Information,2018,31(16):112.[doi:10.3969/j.issn.1006-1959.2018.24.032]
[8]洪 亮,陶 静,张 静,等.上海市男性同性恋HIV感染者中乙型肝炎、丙型肝炎病毒的合并感染情况横断面研究[J].医学信息,2019,32(06):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
　HONG Liang,TAO Jing,ZHANG Jing,et al.Cross-sectional Study on the Co-infection of Hepatitis B and Hepatitis C Virus among HIV-infected People in Shanghai[J].Journal of Medical Information,2019,32(16):145.[doi:10.3969/j.issn.1006-1959.2019.06.046]
[9]肖 戈,尹 杰,林靖波,等.经皮肾镜碎石取石术的疗效及术后复发的危险因素分析[J].医学信息,2019,32(21):98.[doi:10.3969/j.issn.1006-1959.2019.21.030]
　XIAO Ge,YIN Jie,LIN Jing-bo,et al.Therapeutic Effect of Percutaneous Nephrolithotomy and Risk Factors for Postoperative Recurrence of Stones[J].Journal of Medical Information,2019,32(16):98.[doi:10.3969/j.issn.1006-1959.2019.21.030]
[10]杜金洁,胡 鹏.ESKAPE病原菌感染引起脓毒症的研究[J].医学信息,2019,32(21):33.[doi:10.3969/j.issn.1006-1959.2019.21.012]
　DU Jin-jie,HU Peng.Study on Sepsis Caused by ESKAPE Pathogen Infection[J].Journal of Medical Information,2019,32(16):33.[doi:10.3969/j.issn.1006-1959.2019.21.012]

更新日期/Last Update: 1900-01-01