[1]韦柳兴,李镇杰,卢保德.尿α2巨球蛋白在上尿路结石合并尿源性脓毒血症中的诊断价值[J].医学信息,2026,39(10):127-130.[doi:10.3969/j.issn.1006-1959.2026.10.022]
　WEI Liuxing,LI Zhenjie,LU Baode.Diagnostic Value of Urinary α2-macroglobulin in Upper Urinary Tract Calculus with Urosepsis[J].Journal of Medical Information,2026,39(10):127-130.[doi:10.3969/j.issn.1006-1959.2026.10.022]
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尿α2巨球蛋白在上尿路结石合并尿源性脓毒血症中的诊断价值()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年10期
页码:
127-130
栏目:
临床证据信息
出版日期:
2026-05-15

文章信息/Info

Title:
Diagnostic Value of Urinary α2-macroglobulin in Upper Urinary Tract Calculus with Urosepsis
文章编号:
1006-1959（2026）10-0127-04
作者:
韦柳兴; 李镇杰; 卢保德
右江民族医学院附属医院泌尿外科，广西 百色 533000
Author(s):
WEI Liuxing;  LI Zhenjie;  LU Baode
Department of Urology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China
关键词:
尿α2-MG; 尿源性脓毒血症; 上尿路结石
Keywords:
Urinary α2-MG;  Urosepsis;  Upper urinary tract calculus
分类号:
R699；R459.7
DOI:
10.3969/j.issn.1006-1959.2026.10.022
文献标志码:
A
摘要:
目的 探讨尿液α2巨球蛋白（α2-MG）在上尿路结石合并尿源性脓毒血症中的水平变化及诊断价值。方法 选取2023年2月-2024年8月在右江民族医学院附属医院住院的80例上尿路结石合并尿源性脓毒血症患者为尿源性脓毒血症组，收集同期住院的上尿路结石并发尿路感染的80例患者为尿路感染组，80例上尿路结石无尿路感染者为非感染组，收集各组患者尿α2-MG、降钙素原（PCT）、结石位置和大小，以及发生脓毒血症时的降钙素原、尿α2-MG水平，比较三组患者各项指标差异，绘制受试者工作特征（ROC）曲线评估尿α2-MG对尿源性脓毒血症的诊断价值，尿源性脓毒血症以尿培养阳性+符合脓毒症为金标准。结果 尿源性脓毒血症组尿α2-MG水平高于尿路感染组和非感染组，尿路感染组尿α2-MG水平高于非感染组（P＜0.05）。ROC曲线分析显示，尿α2-MG预测上尿路结石患者发生尿源性脓毒血症的ROC曲线AUC为0.897，敏感度为90.12%，特异度为77.50%，尿α2-MG联合血清降钙素原预测发生尿源性脓毒血症的ROC曲线AUC为0.931，敏感度为93.83%，特异度为87.50%。结论 尿α2-MG可作为上尿路结石并发尿源性脓毒血症的诊断标志物，联合血清降钙素原可提高临床诊断效能。
Abstract:
Objective To investigate the changes and diagnostic value of urinary α2-macroglobulin (α2-MG) in patients with upper urinary tract calculus complicated with urosepsis. Methods From February 2023 to August 2024, 80 patients with upper urinary tract calculus complicated with urosepsis in the Affiliated Hospital of Youjiang Medical University for Nationalities were selected as the urosepsis group, 80 patients with upper urinary tract calculus complicated with urinary tract infection in the same period were collected as the urinary tract infection group, and 80 patients with upper urinary tract calculi without urinary tract infection were collected as the non-infection group. Urinary α2-MG, procalcitonin (PCT), stone location and size, procalcitonin and urinary α2-MG at the time of sepsis were collected and compared among the three groups. The receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of urinary α2-MG for urinary sepsis. Urinary sepsis was based on positive urine culture+sepsis as the gold standard. Results The urinary α2-MG level in the urosepsis group was higher than that in the urinary tract infection group and the non-infection group, and the urinary α2-MG level in the urinary tract infection group was higher than that in the non-infection group (P<0.05). ROC curve analysis showed that the AUC of ROC curve of urinary α2-MG in predicting the occurrence of urosepsis in patients with upper urinary tract calculus was 0.897, the sensitivity was 90.12%, and the specificity was 77.50%; the AUC of ROC curve of urinary α2-MG combined with serum procalcitonin in predicting the occurrence of urosepsis was 0.931, the sensitivity was 93.83%, and the specificity was 87.50%. Conclusion Urinary α2-MG can be used as a diagnostic marker for upper urinary tract calculus complicated with urosepsis, and combined with serum procalcitonin can improve the clinical diagnostic efficiency.

相似文献/References:

[1]韦能宝,薛志刚,毕金文.尿源性脓毒血症诊治分析[J].医学信息,2018,31(24):170.[doi:10.3969/j.issn.1006-1959.2018.24.052]
　WEI Neng-bao,XUE Zhi-gang,BI Jin-wen.Diagnosis and Treatment of Urinary Sepsis[J].Journal of Medical Information,2018,31(10):170.[doi:10.3969/j.issn.1006-1959.2018.24.052]

更新日期/Last Update: 1900-01-01