[1]李雨芹,黄顺贵,王思迅,等.醒脑静注射液辅助治疗血管性痴呆的疗效的Meta分析[J].医学信息,2018,31(11):84-88.[doi:10.3969/j.issn.1006-1959.2018.11.026]
 LI Yu-qin,HUANG Shun-gui,WANG Si-xun,et al.Meta Analysis of Efficacy of Xingnaojing Injection in Adjuvant Treatment of Vascular Dementia[J].Journal of Medical Information,2018,31(11):84-88.[doi:10.3969/j.issn.1006-1959.2018.11.026]
点击复制

醒脑静注射液辅助治疗血管性痴呆的疗效的Meta分析()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年11期
页码:
84-88
栏目:
论著
出版日期:
2018-06-01

文章信息/Info

Title:
Meta Analysis of Efficacy of Xingnaojing Injection in Adjuvant Treatment of Vascular Dementia
文章编号:
1006-1959(2018)11-0084-05
作者:
李雨芹黄顺贵王思迅龙秀英
四川省成都市第六人民医院神经内科,四川 成都 610051
Author(s):
LI Yu-qinHUANG Shun-guiWANG Si-xunLONG Xiu-ying
Department of Neurology,the Sixth People's Hospital of Chengdu,Chengdu 610051,Sichuan,China
关键词:
醒脑静血管性痴呆Meta分析
Keywords:
Key words:XingnaojingVascular dementiaMeta-analysis
分类号:
R749.136
DOI:
10.3969/j.issn.1006-1959.2018.11.026
文献标志码:
A
摘要:
目的 采用Meta分析方法对醒脑静注射液辅助治疗血管性痴呆的疗效进行系统评价。方法 在国内外多个数据库中检索已经公开发表的关于醒脑静注射液辅助治疗血管性痴呆的相关文献,通过严格文章筛选应用Review Manager5.3进行Meta分析。结果 共纳入12项研究,分析显示,醒脑静注射液辅助治疗血管性痴呆,改善其临床疗效的比值比(OR)合并值为3.80(95%可信区间为2.70~5.30)。MMSE评分疗效标准化均数差(SMD)合并值为4.02(95%可信区间为3.02~5.01)。ADL评分疗效标准化均数差(SMD)合并值为8.0(95%可信区间为3.70~12.29)。HDS评分疗效标准化均数差(SMD)合并值为4.08(95%可信区间为3.46~4.7)。结论 醒脑静注射液在辅助治疗血管性痴呆效果上,患者智力、精神状态、日常生活能力改善明显。其临床疗效显著。
Abstract:
Abstract:Objective To evaluate the efficacy of Xingnaojing injection in the treatment of vascular dementia by meta-analysis. Methods The published literatures on the adjuvant treatment of vascular dementia with Xingnaojing injection were searched in many databases at home and abroad,and the meta-analysis was carried out by screening and applying Review Manager 5.3 in strict articles. Results A total of 12 studies were included, and the analysis showed that Xingnaojing injection assisted the treatment of vascular dementia, and the ratio(OR)of the clinical efficacy was 3.80(95% confidence interval 2.70~5.30).The MMSE score was standardized with a mean difference(SMD)with a combined value of 4.02(95% confidence interval 3.02~5.01).The ADL score was standardized with a mean difference(SMD)with a combined value of 8(95% confidence interval 3.70~12.29).The HDS score was standardized with a mean difference(SMD)with a combined value of 4.08(95% confidence interval 3.46~4.7).Conclusion Xingnaojing injection improved the intelligence,mental state and daily living ability of patients with adjuvant treatment of vascular dementia.The clinical effect is remarkable.

参考文献/References:

[1]邓秀斌.探讨醒脑静注射液治疗急性重症脑血管病的临床疗效[J].医学信息,2016,29(5):172-172. [2]李春艳,刘晓明,高善语,等.醒脑静对急性脑梗死的血管炎性反应干预[J].荷泽医学专科学校学报,2014,26(4):77-78. [3]尚亚细亚,杜菊梅.醒脑静注射液治疗血管性痴呆临床观察[J].实用中医药杂志,2016,32(11):1131-1132. [4]邓虹,刘万平,何兴林,等.醒脑静联合尼莫地平治疗血管性痴呆及对患者精神行为症状的影响[J].西部医学,2016,28(7): 979-982. [5]陈伟鑫.醒脑静和尼莫地平联合治疗血管性痴呆78例疗效观察[J].中国实用神经疾病杂志,2015,18(5):77-78. [6]沈治军,陈海洪,缪抱红.联合应用醒脑静和石杉碱甲治疗血管性痴呆的效果观察[J].当代医药论丛,2015,13(19):235-237. [7]赵钧.醒脑静联合维脑路通及脑活素治疗血管性痴呆60例观察[J].实用中医药杂志,2015,31(12):1134-1134. [8]徐旭然.醒脑静联合胞二磷胆碱注射液治疗30例血管性痴呆疗效观察[J].现代诊断与治疗,2014,25(17):3969-3970. [9]王建强,刘云凤.醒脑静联合胞二磷胆碱注射液治疗血管性痴呆40例[J].江西中医药,2014,45(1):41-42. [10]谭志勇.醒脑静联合尼莫地平治疗血管性痴呆临床疗效[J].中医临床研究,2014,6(3):70-72. [11]陈中锋.联合用药治疗血管性痴呆42例临床疗效观察[J].中外医学研究,2010,8(20):60-61. [12]李立新,贺雪琴.醒脑静注射液联合尼莫地平治疗血管性痴呆临床观察[J].吉林医学,2010,31(8):1027-1028. [13]张祥麟,张文秀,高仲楼,等.醒脑静治疗脑血管性痴呆38例[J].陕西中医,2003,24(2):134-135. [14]王立新,刘国华.醒脑静注射液对血管性痴呆患者智能及脂蛋白的影响[J].河北中医,1999,21(2): 75-76. [15]Gao YZ,Zhang JJ,Liu H,et al.Regional cerebral blood flow and cerebrovascular in Alzheimer's disease and vascular dementia assessed by arterial spinlabeling magnetic resonance imaging[J]. Curr Neurovasc Res,2013,10(1):49-53. [16]廖伟龙,孙传河,高鹏琳,等.血管性痴呆的危险因素及发病机制的研究进展[J].中西医结合心脑血管病杂志,2017,15(8): 941-944. [17]吴作林,陈健,郭飞,等.醒脑静对老年脑梗死患者神经细胞修复相关细胞因子的影响[J].医学综述,2016,22(21):4312-4315. [18]翟娜,刘岩.醒脑静注射液对高血压脑出血患者炎症因子的影响[J].中国实用神经疾病杂志,2015,18(8):118-119. [19]卢志刚,黄家彬,刘芸,等.醒脑静注射液对急性脑梗死Keap1-Nrf2/ARE氧化应激通路的影响[J].广东医学,2016,37(20):3127-3129. [20]马斌,刘璐,张扬,等.醒脑静注射液对高血压脑梗死大鼠模型的神经保护作用[J].中西医结合心脑血管病杂志,2014,12(2):212-214. 收

相似文献/References:

[1]金 凤,肖 萌.血管性痴呆合并甲状腺功能减退发生率的研究[J].医学信息,2018,31(21):106.[doi:10.3969/j.issn.1006-1959.2018.21.029]
 JIN Feng,XIAO Meng.Study on the Incidence of Vascular Dementia Complicated with Hypothyroidism[J].Journal of Medical Information,2018,31(11):106.[doi:10.3969/j.issn.1006-1959.2018.21.029]
[2]刘永刚,张学勇.醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者的疗效分析[J].医学信息,2019,32(06):157.[doi:10.3969/j.issn.1006-1959.2019.06.050]
 LIU Yong-gang,ZHANG Xue-yong.Therapeutic Effect of Xingnaojing Combined with Naloxone Hydrochloride on Patients with Coma after Cerebral Hemorrhage[J].Journal of Medical Information,2019,32(11):157.[doi:10.3969/j.issn.1006-1959.2019.06.050]
[3]赵 钟.针灸治疗血管性痴呆的研究[J].医学信息,2022,35(15):175.[doi:10.3969/j.issn.1006-1959.2022.15.042]
 ZHAO Zhong.Study on Acupuncture Treatment of Vascular Dementia[J].Journal of Medical Information,2022,35(11):175.[doi:10.3969/j.issn.1006-1959.2022.15.042]
[4]李雨芹,刘 梅.石杉碱甲联合尼莫地平治疗血管性痴呆疗效与安全性的Meta分析[J].医学信息,2020,33(11):82.[doi:10.3969/j.issn.1006-1959.2020.11.024]
 LI Yu-qin,LIU Mei.Meta Analysis of the Efficacy and Safety of Huperzine A Combined with Nimodipine in the Treatment of Vascular Dementia[J].Journal of Medical Information,2020,33(11):82.[doi:10.3969/j.issn.1006-1959.2020.11.024]
[5]晏艳平,许小兵,刘敏鹃.安神益智针法联合电刺激对血管性痴呆患者的认知功能、氧自由基及IL-6的影响[J].医学信息,2023,36(18):94.[doi:10.3969/j.issn.1006-1959.2023.18.017]
 YAN Yan-ping,XU Xiao-bing,LIU Min-juan.Effects of Anshen Yizhi Acupuncture Combined with Electrical Stimulation on Cognitive Function,Oxygen Free Radical and IL-6 in Patients with Vascular Dementia[J].Journal of Medical Information,2023,36(11):94.[doi:10.3969/j.issn.1006-1959.2023.18.017]
[6]张洪敏.纳洛酮联合醒脑静在COPD合并Ⅱ型呼吸衰竭中的疗效及对预后的影响[J].医学信息,2023,36(22):82.[doi:10.3969/j.issn.1006-1959.2023.22.017]
 ZHANG Hong-min.Effect of Naloxone Combined with Xingnaojing in COPD with Type Ⅱ Respiratory Failureand its Effect on Prognosis[J].Journal of Medical Information,2023,36(11):82.[doi:10.3969/j.issn.1006-1959.2023.22.017]
[7]孙 勇.多奈哌齐联合丁苯酞治疗血管性痴呆的临床疗效及对神经功能恢复的影响[J].医学信息,2023,36(23):77.[doi:10.3969/j.issn.1006-1959.2023.23.019]
 SUN Yong.Clinical Efficacy of Donepezil Combined with Butylphthalide in the Treatment of Vascular Dementia and its Effect on the Recovery of Neurological Function[J].Journal of Medical Information,2023,36(11):77.[doi:10.3969/j.issn.1006-1959.2023.23.019]

更新日期/Last Update: 2018-06-01