[1]张小龙.P53在胆囊癌临床预后中的预测意义[J].医学信息,2018,31(11):156-158.[doi:10.3969/j.issn.1006-1959.2018.11.051]
 ZHANG Xiao-long.Predictive Significance of P53 in Clinical Prognosis of Gallbladder Carcinoma[J].Journal of Medical Information,2018,31(11):156-158.[doi:10.3969/j.issn.1006-1959.2018.11.051]
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P53在胆囊癌临床预后中的预测意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年11期
页码:
156-158
栏目:
诊疗技术
出版日期:
2018-06-01

文章信息/Info

Title:
Predictive Significance of P53 in Clinical Prognosis of Gallbladder Carcinoma
文章编号:
1006-1959(2018)11-0156-03
作者:
张小龙
河北省武安市第一人民医院肝胆外科,河北 武安 056300
Author(s):
ZHANG Xiao-long
Department of Hepatobiliary Surgery,First People's Hospital of Wu'an,Wu'an 056300,Hebei,China
关键词:
P53胆囊癌免疫组化
Keywords:
Key words:P53Gallbladder carcinomaImmunohistochemistry
分类号:
R473.6
DOI:
10.3969/j.issn.1006-1959.2018.11.051
文献标志码:
A
摘要:
目的 探讨P53在胆囊癌患者中表达情况与胆囊癌患者术后临床治疗之间关系。方法 采用免疫组化法检测我院自2010年~2016年47例胆囊癌患者的P53阳性表达情况,并且采用统计学方法比较其临床意义。结果 P53阳性表达与性别、年龄无关(P>0.05),与肿瘤大小、手术方式、TMN分期存在密切关系(P<0.05);并且P53表达阳性与肿瘤大小、手术方式、TMN分期呈正相关(P<0.05),差异有统计学意义。结论 P53可作为胆囊癌患者术后病情预测评估指标之一,对其后续治疗做出指导。
Abstract:
Abstract:Objective To investigate the relationship between the expression of P53 in gallbladder cancer patients and clinical treatment of gallbladder cancer patients.Methods Immunohistochemistry was used to detect the positive expression of P53 in 47 patients with gallbladder carcinoma from 2010 to 2016 in our hospital.Statistical significance was used to compare their clinical significance.Results The positive expression of P53 was not related to gender and age(P>0.05).It was closely related to tumor size, surgical methods,and TMN stage(P<0.05).And the positive expression of P53 was positively correlated with tumor size,surgical method, and TMN stage(P<0.05),the difference was statistically significant.Conclusion P53 can be used as a predictive index for the evaluation of postoperative conditions in patients with gallbladder carcinoma,and it can guide the follow-up treatment.

参考文献/References:

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更新日期/Last Update: 2018-06-01