[1]冯贺强,张彩红.肠道菌群与非酒精性脂肪肝关系的研究进展[J].医学信息,2018,31(12):47-49,53.[doi:10.3969/j.issn.1006-1959.2018.12.015]
 FENG He-qiang,ZHANG Cai-hong.Research Progress on the Relationship between Intestinal Flora and Nonalcoholic Fatty Liver[J].Journal of Medical Information,2018,31(12):47-49,53.[doi:10.3969/j.issn.1006-1959.2018.12.015]
点击复制

肠道菌群与非酒精性脂肪肝关系的研究进展()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年12期
页码:
47-49,53
栏目:
综述
出版日期:
2018-06-15

文章信息/Info

Title:
Research Progress on the Relationship between Intestinal Flora and Nonalcoholic Fatty Liver
文章编号:
1006-1959(2018)12-0047-04
作者:
冯贺强张彩红
天津市第五中心医院检验科,天津 300450
Author(s):
FENG He-qiangZHANG Cai-hong
Department of Clinical Laboratory,Tianjin Fifth Central Hospital,Tianjin 300450,China
关键词:
肠道菌群非酒精性脂肪性肝病机制
Keywords:
Key words:Intestinal floraNonalcoholic fatty liver diseaseMechanism
分类号:
R575.5
DOI:
10.3969/j.issn.1006-1959.2018.12.015
文献标志码:
A
摘要:
近年来非酒精性脂肪性肝病的发病率不断增加,虽然属于慢性肝病,但是患者有发展为肝硬化的风险,为临床治疗带来了很多难题。本文综述非酒精性脂肪性肝病的发病机制,分析肠道菌群与非酒精性脂肪性肝病的因果关系,寻求潜在有效的新型治疗方案。
Abstract:
Abstract:In recent years,the incidence of nonalcoholic fatty liver disease has been increasing.Although it is a chronic liver disease, patients have a risk of developing cirrhosis,which brings many problems for clinical treatment.This article reviews the pathogenesis of nonalcoholic fatty liver disease,analyzes the causal relationship between intestinal flora and nonalcoholic fatty liver disease,and seeks potentially effective new treatment options.

参考文献/References:

[1]Wu J,Xu H,Wang C,et al.The 6-year changes of epidemiology of non-alcoholic fatty liver disease among general population of northeastern in China[J].Hepatol Int,2017(11):S562.
[2]肖丽,杨玲.肠道菌群与非酒精性脂肪性肝病的关系[J].临床肝胆病杂志,2017,33(4):774-779.
[3]Blaut M.Gut microbiota and energy balance:role in obesity[J].Proc Nutr Soc,2015,74(3):227-234.
[4]Day CP,James OF.Steatohepatitis:a tale of two"hits"[J].Gastroenterology,1998,114(4):842-845.
[5]Jou J,Choi SS,Diehl AM.Mechanisms of disease progression in nonalcoholic fatty liver disease[J].Semin Liver Dis,2008,28(4):370-379.
[6]廉晓晓,郭晓霞.肠-肝轴学说的研究进展[J].中西医结合肝病杂志,2017,27(4):251-254.
[7]Paolella G,Mandato C,Pierri L,et al.Gut liver axis and probioties:their role in non-alcoholic fatty liver disease[J].World J Gastroenterol,2014,20(42):15518-15531.
[8]王全楚,步子恒.肠肝轴的现代概念及其在肝脏疾病中的作用[J].胃肠病学和肝脏病学杂志,2015,24(9):1155-1158.
[9]Ratziu V,Goodman Z,Sanyal A.Current efforts and trends in the treatment of NASH[J].J Hepatol,2015,62(1 Suppl):S65-S75.
[10]Hollister EB,Gao C,Versalovic J.Compositional and functional features of the gastrointestinal microbiome and their effects on human health[J].Gastroenterology,2014,146(6):1449-1458.
[11]Lozupone CA,Stombaugh JI,Gordon JI,et al.Diversity,stability and resilience of the human gut microbiota[J].Nature,2012,489(7415):220-230.
[12]Shen F,Zheng RD,Sun X,et al.Gut microbiota structure in patients with non-alcoholic fatty liver disease[J].Hepatol Int,2017(11):S252.
[13]Abu-Shanab A,Quigley EMM.The role of the gut microbiota in nonalcoholic fatty liver disease[J].Nature Reviews Gastroenterology and Hepatology,2010,7(12):691-701.
[14]Camp JG,Jazwa AL,Trent CM,et al.Introniccis-regulatory modules mediate tissue-Specific and microbial control of angptl4 fiaf transcription[J].PLoS geneties,2012,8(3):e1002585.
[15]Schnabl B,Brenner DA.Interactions between the intestinal microbeome and liver diseases [J].Gastroenterology,2014,146(6):1513-1524.
[16]Backhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proceedings of the National Academy of Sciences,2007,104(3):979-984.
[17]Nascimbeni F,Pais R,Bellen-tani S,et al.From NAFLD in clinical practice to answers from guidelines[J].J Hepatol,2013,59(4):859-871.
[18]Caricill AM,Saad MJ.The role of gut microbiota on insulin resistance[J].Nutrients,2013,5(3):829-851.
[19]Cani PD,Bibiloni R,Knauf C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-indnced obesity and diabetes in mice[J].Diabetes,2008,57(6):1470-1481.
[20]Trauner M,Claudel T,Fickert P,et al.Bile acids as regulators of hepatic lipid and glucose metabolism[J].Dig Dis,2010,28(1):220-224.
[21]Broeders EP,Nascimento EB,Havekes B,et al.The bile acid chenodeoxycholic acid increases human brown adipose tissue activity[J].Cell Metab,2015,22(3):418-426.
[22]Fuchs C,Claudel T,Trauner M.Bile acid-nlediated control of liver triglycerides[J].Semin Liver Dis,2013,33(4):330-342.
[23]Lu W,Wang C,Luo X,et al.PB-718,a dual GLP-1 glucagon receptor agonist demonstrates superior weight loss effect and ameliorates nonalcoholic steatohepatitis(NASH)in animal models[J].Hepatol Int,2017(11):S958.
[24]Degirolamo C,Modica S,Vacca M,et al.Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor- null mice by intestinal- specific farnesoid X receptor reactivation[J].Hepatology,2015,61(1):161-170.
[25]Sayin S,Wahlstrom A,Felin J,et al.Gutmicrobiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholicacid,a naturally occurring FXR antagonist[J].Cell Metab,2013,17(2):225-235.
[26]Koeth RA.Intestinalmicrobiota metabolism of L-carnitine,a nutrient in red meat,promotes atherosclerosis[J].Nat Med,2013(19):576-585.
[27]Gao X,Liu X,Xu J,et al.Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet[J].J Biosci Bioeng,2014,118(4):476-481.
[28]Fennema D,Philips IR,Shephard EA.Trimethylamine and Trimethylamine N-Oxide,a Flavin-Containing Monooxygenase 3(FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease[J].Drug Metab Dispos,2016,44(11):1839-1850.
[29]ThuyS,LadurnerR,Volynets V,et al.Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor lconcentrations and with fructose intake[J].The Journal of nutrition,2008,138(8):1452-1455.
[30]Miele L,Valenza V,La Torre G,et al.Increased intestinal pemaeability and tight junction alterations in nonalcoholic fatty liver disease[J].Hepatology,2009,49(61):1877-1887.
[31]Henao-Mejia J,Elinav E,Jin C,et al.Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity[J].Nature,2012,482(7384):179-185.
[32]Rivera CA,Adegboyega P,van Rooijen N,et al.Toll-like receptor-4 signaling and Kupffer cell splay pivotal roles in the pathogenesis of non-alcoholic steatohepatitis[J].J Hepatol,2007,47(2):571-579.
[33]Charlton MR,Bums JM,Pedersen RA,et al.Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States[J].Gastroemerology,2011,141(4):1249-1253.
[34]何崇信,徐正婕.内生性乙醇与非酒精性脂肪性肝病研究进展[J].实用肝脏病杂志,2016,19(1):109-112.
[35]Baker SS,Baker RD,Liu W,et al.Role of alcohol metabolism innon-alcoholic steatohepatitis[J].PLoS One,2010,5(3):e9570.
[36]Kwon HJ,Won YS,Park O,et al.Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice[J].Hepatology,2014,60(1):146-157.

相似文献/References:

[1]龙 颖,李运泽,汤中敏,等.非酒精性脂肪性肝病与血尿酸水平测定及其临床意义[J].医学信息,2018,31(07):92.[doi:10.3969/j.issn.1006-1959.2018.07.029]
 LONG Ying,LI Yun-ze,TANG Zhong-min,et al.Determination of Serum Uric Acid Level and its Clinical Significance in Non-alcoholic Fatty Liver Disease[J].Journal of Medical Information,2018,31(12):92.[doi:10.3969/j.issn.1006-1959.2018.07.029]
[2]崔姗姗,刘 英,江 霞.非酒精性脂肪性肝病与胰岛素抵抗的研究进展[J].医学信息,2022,35(10):66.[doi:10.3969/j.issn.1006-1959.2022.10.016]
 CUI Shan-shan,LIU Ying,JIANG Xia.Research Progress on Non-alcoholic Fatty Liver Disease and Insulin Resistance[J].Journal of Medical Information,2022,35(12):66.[doi:10.3969/j.issn.1006-1959.2022.10.016]
[3]向姣姣,李国娟,杨通艳,等.肠道菌群与肥胖发病机制的研究[J].医学信息,2022,35(10):70.[doi:10.3969/j.issn.1006-1959.2022.10.017]
 XIANG Jiao-jiao,LI Guo-juan,YANG Tong-yan,et al.Study on Intestinal Flora and Pathogenesis of Obesity[J].Journal of Medical Information,2022,35(12):70.[doi:10.3969/j.issn.1006-1959.2022.10.017]
[4]张 慧,胡广越,殷 红.菌群干预与免疫治疗的研究进展[J].医学信息,2022,35(11):54.[doi:10.3969/j.issn.1006-1959.2022.11.016]
 ZHAHG Hui,HU Guang-yue,YIN Hong.Research Progress in Microbial Intervention and Immunotherapy[J].Journal of Medical Information,2022,35(12):54.[doi:10.3969/j.issn.1006-1959.2022.11.016]
[5]郑 颖,孙华胜,毛乾国.中医防治非酒精性脂肪性肝病研究进展[J].医学信息,2018,31(15):25.[doi:10.3969/j.issn.1006-1959.2018.15.010]
 ZHENG Ying,SUN Hua-sheng,MAO Qian-guo.Progress in Prevention and Treatment of Nonalcoholic Fatty Liver Disease by TCM[J].Journal of Medical Information,2018,31(12):25.[doi:10.3969/j.issn.1006-1959.2018.15.010]
[6]李珊珊,陈少彬,龚先琼.中药单体治疗非酒精性脂肪性肝病研究进展[J].医学信息,2018,31(21):24.[doi:10.3969/j.issn.1006-1959.2018.21.008]
 LI Shan-shan,CHEN Shao-bin,GONG Xian-qiong.Advances in Research of Traditional Chinese Medicine Monomer in the Treatment of Non-alcoholic Fatty Liver Disease[J].Journal of Medical Information,2018,31(12):24.[doi:10.3969/j.issn.1006-1959.2018.21.008]
[7]姜海燕.双歧杆菌四联活菌治疗对肝硬化患者肝功能、细胞因子及肠道菌群的影响[J].医学信息,2022,35(12):156.[doi:10.3969/j.issn.1006-1959.2022.12.038]
 JIANG Hai-yan.Effect of Quadruple Viable Bifidobacterium Treatment on Liver Function, Cytokines and Intestinal Flora in Patients with Liver Cirrhosis[J].Journal of Medical Information,2022,35(12):156.[doi:10.3969/j.issn.1006-1959.2022.12.038]
[8]黄玲玉,孙 东,蒋本君,等.天津市某区域体检人群非酒精性脂肪肝调查分析[J].医学信息,2019,32(04):99.[doi:10.3969/j.issn.1006-1959.2019.04.032]
 HUANG Ling-yu,SUN Dong,JIANG Ben-jun,et al.Investigation and Analysis of Non-alcoholic Fatty Liver Disease in Medical Examination Population in A Certain Area of Tianjin[J].Journal of Medical Information,2019,32(12):99.[doi:10.3969/j.issn.1006-1959.2019.04.032]
[9]余 辉,李 岳,郭宝娜.非酒精性脂肪性肝病的治疗研究[J].医学信息,2019,32(14):38.[doi:10.3969/j.issn.1006-1959.2019.14.014]
 YU Hui,LI Yue,GUO Bao-na.Treatment of Non-alcoholic Fatty Liver Disease[J].Journal of Medical Information,2019,32(12):38.[doi:10.3969/j.issn.1006-1959.2019.14.014]
[10]王佳欣,毛乾国.慢性乙型肝炎合并非酒精性脂肪性肝病 中医辨治的研究进展[J].医学信息,2019,32(16):38.[doi:10.3969/j.issn.1006-1959.2019.16.012]
 WANG Jia-xin,MAO Qian-guo.Advances in Research on TCM Syndrome Differentiation of Chronic Hepatitis B with Nonalcoholic Fatty Liver Disease[J].Journal of Medical Information,2019,32(12):38.[doi:10.3969/j.issn.1006-1959.2019.16.012]

更新日期/Last Update: 2018-06-15