[1]周 鑫,王 明,魏 宏.药物流产终止乙肝病毒感染患者10~14周妊娠的 安全性及有效性分析[J].医学信息,2018,31(12):112-114.[doi:10.3969/j.issn.1006-1959.2018.12.035]
　ZHOU Xin,WANG Ming,WEI Hong.Analysis of Safety and Effectiveness of Stopping Hepatitis B Virus Infection in 10 to 14 Weeks of Pregnancy by Drug Abortion[J].Journal of Medical Information,2018,31(12):112-114.[doi:10.3969/j.issn.1006-1959.2018.12.035]
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药物流产终止乙肝病毒感染患者10~14周妊娠的 安全性及有效性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年12期
页码:
112-114
栏目:
临床研究
出版日期:
2018-06-15

文章信息/Info

Title:
Analysis of Safety and Effectiveness of Stopping Hepatitis B Virus Infection in 10 to 14 Weeks of Pregnancy by Drug Abortion
文章编号:
1006-1959（2018）12-0112-03
作者:
周 鑫; 王 明; 魏 宏
首都医科大学附属北京佑安医院妇产科，北京 100069
Author(s):
ZHOU Xin; WANG Ming; WEI Hong
Department of Obstetrics and Gynecology,Beijing You'an Hospital,Capital Medical University,Beijing 100069,China
关键词:
米非司酮; 米索前列醇; HBV感染; 有效性; 安全性
Keywords:
Key words：Mifepristone; Misoprostol; HBV Infection; Effectiveness; Safety
分类号:
R719.3
DOI:
10.3969/j.issn.1006-1959.2018.12.035
文献标志码:
A
摘要:
目的 观察药物流产终止乙型肝炎病毒感染患者10~14周妊娠的安全性及有效性。方法 选取我院2013年1月~2017年12月120例乙型肝炎患者作为观察组，其中大三阳46例，小三阳74例，肝功能均正常。选取同期非肝病药物流产患者60例作为对照组，两组患者均采用药物终止妊娠。比较两组患者流产成功率、转氨酶水平和药物副反应。结果 观察组流产成功率86.67%，对照组的流产成功率为 88.33%，两组比较，差异无统计学意义（P＞0.05）；药物流产前后两组患者转氨酶比较，差异无统计学意义（P＞0.05）；药物副反应包括胃肠道反应、过敏反应、阴道出血，两组比较，差异均无统计学意义（P＞0.05）。结论 两组患者完全流产率无差异，无严重副反应及重症肝炎的发生，说明乙型肝炎患者孕10~14周行药物流产是安全有效的，作为非侵入性终止妊娠的方法值得推广应用。
Abstract:
Abstract：Objective To observe the safety and efficacy of medical abortion for termination of hepatitis B virus infection in 10 to 14 weeks of pregnancy.Methods 120 patients with hepatitis B from January 2013 to December 2017 were selected as the observation group,including 46 cases of Dasanyang and 74 cases of Xiaosanyang.The liver function was normal.A total of 60 patients with non-hepatopathy induced abortion were selected as the control group.Both groups were treated with drugs to terminate pregnancy.The success rate of abortion, transaminase levels,and side effects were compared between the two groups.Results The success rate of abortion was 86.67% in the observation group and 88.33% in the control group.There was no significant difference between the two groups(P>0.05).There was no significant difference in transaminase between the two groups before and after drug abortion(P>0.05);There were no significant differences in drug side effects including gastrointestinal reactions,allergic reactions,and vaginal bleeding between the two groups(P>0.05).Conclusion There is no difference in complete abortion rate between the two groups, no serious side effects and severe hepatitis,indicating that hepatitis B patients undergoing medical abortion 10 to 14 weeks of pregnancy is safe and effective,and it is worth to promote the use of non-invasive termination of pregnancy.

参考文献/References:

[1]Liang X,Bi S,Yang W,et al.EpidemiologicaI serosurvey of hepatitis B in China-declining HBV prevalence due to hepatitis B vaccination[J].Vaccine,2013,27(47):6550-6557.
[2]Chen AP,Setser A,Anadkat MJ,et al.Grading dermatologic adverse events of cancer treatments:The Common Terminology Criteria for Adverse Events Version 4.0[J].Journal of the American Academy of Dermatology,2012,67(5):1025-1039.
[3]高树芬.药物流产后阴道出血的临床治疗方法探讨[J].河北医药,2014,20(12):2038-2040.
[4]钱金凤,经小平,武淑英,等.米非司酮配伍米索前列醇终止8~16周妊娠有效性及安全性的临床研究[J].中华妇产科杂志,2015,50(7):505-509.
[5]中华医学会计划生育学分会.米非司酮配伍米索前列醇终止8~16周妊娠的应用指南[J].中华妇产科杂志,2015,50(5):321-322.
[6]Chaudhuri P,Mandal A,Das C,et al.Dosing interval of 24hours versus 48hours between mifepristone and misoprostol administration for mid-trimester termination of pregnancy[J].Int J Gynaecol Obstet,2014,124(2):134-138.
[7]Dickinson JE,Jennings BG,Doherty DA.Mifepristone and oral, vaginal,or sublingual misoprostol for second-trimester abortion: a randomized controlled trial[J].Obstet Gynecol,2014,123(6):1162-1168.
[8]杨秀琴.米非司酮流产后血清转氨酶升高[J].药物不良反应杂志,2002,4(5):336-337.
[9]李玉荣.药物流产及无痛人工流产术终止早期妊娠的流产效果及不良反应[J].医学信息,2013,26(5):299．

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更新日期/Last Update: 2018-06-15