[1]王 程,李弘扬,马鹏程.异维A酸少见不良反应及相应对策[J].医学信息,2018,31(13):45-51.[doi:10.3969/j.issn.1006-1959.2018.13.014]
 WANG Cheng,LI Hong-yang,MA Peng-cheng.Uncommon Adverse Reactions of Isotretinoin and Corresponding Countermeasures[J].Journal of Medical Information,2018,31(13):45-51.[doi:10.3969/j.issn.1006-1959.2018.13.014]
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异维A酸少见不良反应及相应对策()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年13期
页码:
45-51
栏目:
综述
出版日期:
2018-07-01

文章信息/Info

Title:
Uncommon Adverse Reactions of Isotretinoin and Corresponding Countermeasures
文章编号:
1006-1959(2018)13-0045-07
作者:
王 程李弘扬马鹏程
中国医学科学院皮肤病医院,江苏 南京 210000
Author(s):
WANG ChengLI Hong-yangMA Peng-cheng
Dermatology Hospital,Chinese Academy of Medical Sciences,Nanjing 210000,Jiangsu,China
关键词:
异维A酸不良反应治疗
Keywords:
Key words:IsotretinoinAdverse reactionsTreatment
分类号:
R969
DOI:
10.3969/j.issn.1006-1959.2018.13.014
文献标志码:
A
摘要:
异维A酸又名13-顺式维A酸,是维生素A代谢中出现的天然生理活性性物质,在皮肤科疾病中有着广泛的运用,但随着其数十年的临床应用以及使用范围的逐渐推广,一些少见的不良反应也在逐渐被发现和报道。为异维A酸的临床安全用药提供警示,本文收集了近年来的报道,并对其相应的对策做了简单的分析总结。
Abstract:
Abstract:Isotretinoin,also known as 13-cis-retinoic acid,is a natural physiological active substance in vitamin A metabolism and is widely used in dermatological diseases.However,with its decades of clinical application and use of the scope of gradual promotion,some rare adverse reactions are also gradually found and reported.In order to provide warning for the safe use of Isotretinoin in clinic,this paper collected the reports in recent years,and made a simple analysis and summary of the corresponding countermeasures.

参考文献/References:

[1]Nickle SB,Peterson N,Peterson M.Updated Physician's Guide to the Off-label Uses of Oral Isotretinoin[J].J Clin Aesthet Dermatol,2014,7(4):22-34. [2]Figueiras DA,Ramos TB,Marinho AK,et al.Paronychia and granulation tissue formation during treatment with isotretinoin[J].An Bras Dermatol,2016,91(2):223-225. [3]Bigby M,Stern R.Adverse reactions to isotretinoin β:A report from the Adverse Drug Reaction Reporting System[J].Journal of the American Academy of Dermatology,1988,18(3):543-552. [4]Baran S.Etretinate and the nails(study of 130 cases)possible mechanisms of some side-effects[J].Clin Exp Dermatol,1986,11(2):148-152. [5]Alli N,Dogan S.Short-term isotretinoin-induced elkonyxis and median nail dystrophy[J].Cutan Ocul Toxicol,2016,35(1):85-86. [6]Gregoriou S,Banaka F,Rigopoulos D.Isotretinoin-induced transverse leuconychia[J].J Eur Acad Dermatol Venereol,2016,30(2):385-386. [7]Alden K,Chowdhury MM,Williams PE,et al.Protocol for investigation of possible soya allergy in patients being considered for treatment with isotretinoin or alitretinoin[J].Clin Exp Dermatol,2016,41(3):326-327. [8]Pierret L,Grosber M,Gutermuth J.Is isotretinoin treatment safe in patients with known peanut allergy[J].J Eur Acad Dermatol Venereol,2016,30(1):140-141. [9]Conely J,Polcari I.Novel nickel contact dermatitis in a patient taking isotretinoin[J].Pediatr Dermatol,2014,31(6):e154-e155. [10]Simmons BJ,Chen L,Hu S.Pyogenic granuloma association with isotretinoin treatment for acne[J].Australas J Dermatol,2016,57(4):e144-e145. [11]Kontaxakis V,Skourides D,Ferentinos P.Isotretinoin and psychopathology:a review[J].Annals of General Psychiatry,2009,8(1):1-8. [12]Simic D,Situm M,Letica E.Psychological impact of isotretinoin treatment in patients with moderate and severe acne[J].Coll Antropol,2009,33(2):15-19. [13]Kaymak Y,Taner E,Taner Y.Comparison of depression,anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents[J].Int J Dermatol,2009,48(1):41-46. [14]Bozdag K,Gulseren S,Guven F,et al.Evaluation of depressive symptoms in acne patients treated with isotretinoin[J].J Dermatolog Treat,2009,20(5):293-296. [15]Valderrama F,Gomez A,Restrepo D.Isotretinoin Therapy for Acne Vulgaris and First Episode Psychosis in an Adolescent Patient[J].Rev Colomb Psiquiatr,2017,46(1):50-54. [16]Le Moigne M,Bulteau S,Grall-Bronnec M,et al.Psychiatric disorders,acne and systemic retinoids:comparison of risks[J].Expert Opin Drug Saf,2017,16(9):989-995. [17]Oliveira JM,Sobreira G,Velosa J,et al.Association of Isotretinoin With Depression and Suicide:A Review of Current Literature[J].Journal of Cutaneous Medicine and Surgery,2018,22(1):58-64. [18]Guler E,Babur GG,Yavuz C,et al.An unknown side effect of isotretinoin:Pericardial effusion with atrial tachycardia[J].Anatol J Cardiol,2015,15(2):168-169. [19]Alan S,Unal B,Yildirim A.Premature ventricular contractions associated with isotretinoin use[J].An Bras Dermatol,2016,91(6):820-821. [20]Karadag AS,Ertugrul DT,Takci Z.Isotretinoin modestly increases platelet count in acne patients[J].J Dermatolog Treat,2013,24(2):139-140. [21]Ataseven A,Ugur BA.Effects of Isotretinoin on the Platelet Counts and the Mean Platelet Volume in Patients with Acne Vulgaris[J].Scientific World Journal,2014,2014(1):156464. [22]Seckin HY,Bas Y,Takci Z,et al.Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris[J].Cutan Ocul Toxicol,2016,35(2):89-91. [23]Rashtak S,Khaleghi S,Pittelkow MR,et al.Isotretinoin exposure and risk of inflammatory bowel disease[J].JAMA Dermatol,2014,150(12):1322-1326. [24]Bendezu-Garcia RA,Hernandez-Martinez A,Patron-Roman GO,et al.Ulcerative colitis and isotretinoin:Is there a causal relationship[J].Rev Esp Enferm Dig,2014,106(2):150-151. [25]Lee SY,Jamal MM,Nguyen ET,et al.Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease.A meta-analysis [J].Eur J Gastroenterol Hepatol,2016,28(2):210-216. [26]Baykal SL,Aksu AD,Baykal SH,et al.The prevalence of sacroiliitis in patients with acne vulgaris using isotretinoin[J].Cutan Ocul Toxicol,2017,36(2):176-179. [27]Kocak O,Kocak AY,Sanal B,et al.Bilateral Sacroiliitis Confirmed with Magnetic Resonance Imaging during Isotretinoin Treatment: Assessment of 11 Patients and a Review of the Literature[J].Acta Dermatovenerol Croat,2017,25(3):228-233. [28]Geller AS,Alagia RF.Sacroiliitis after use of oral isotretinoin-associationwith acne fulminans or adverse effect[J].An Bras Dermatol,2013,88(6 Suppl 1):193-196. [29]Alkan S,Kayiran N,Zengin O,et al.Isotretinoin-induced Spondyloarthropathy-related Symptoms:A Prospective Study[J].J Rheumatol,2015,42(11):2106-2109. [30]Yildizgoren MT,Rifaioglu EN,Demirkapi M,et al.Isotretinoin treatment in patients with acne vulgaris:does it impact muscle strength,fatigue,and endurance[J].Cutis,2015,96(1):33-36. [31]Karadag AS,Takci Z,Ertugrul DT,et al.The effect of different doses of isotretinoin on pituitary hormones[J].Dermatology,2015,230(4):354-359. [32]Uyar B,Solak A,Saklamaz A,et al.Effects of isotretinoin on the thyroid gland and thyroid function tests in acne patients:A preliminary study[J].Indian J Dermatol Venereol Leprol,2016,82(5):587-588. [33]Yildirim N,Dogan S,Atakan N.Evaluation of thyroid function tests of acne vulgaris patients treated with systemic isotretinoin[J].J Dermatolog Treat,2017,28(2):141-144. [34]Ustun I,Rifaioglu EN,Sen BB,et al.Gynecomastia:a rare complication of isoretinoin[J].Cutan Ocul Toxicol,2013,32(1):93-94. [35]Cinar L,Kartal D,Ergin C,et al.The effect of systemic isotretinoin on male fertility[J].Cutan Ocul Toxicol,2016,35(4):296-299. [36]Cinar SL,Kartal D,Aksoy H,et al.Long-term effect of systemic isotretinoin on female fertility[J].Cutan Ocul Toxicol,2017,36(2):132-134. [37]Solak B,Erdem T,Solak Y.Isotretinoin use for acne vulgaris is associated with increased serum uric acid levels[J].J Dermatolog Treat,2017,28(1):82-85. [38]Yesilkaya B,Alli N,Artuz RF,et al.The frequency of hematuria in acne vulgaris patients during isotretinoin treatment[J].Cutan Ocul Toxicol,2017,36(1):74-76. [39]Ballout RA,Maatouk I.Isotretinoin-induced urethritis versus non-gonococcal urethritis in a man who has sex with men:an open debate[J].International Journal of STD&AIDS,2018(1):1615161502. [40]Johnson M,O'Colmain U,Affleck A.Recurrent corneal erosion associated with oral isotretinoin:a cautionary tale[J].Clin Exp Dermatol,2016,41(5):564. [41]Topal IO.Dyspareunia and vaginal bleeding associated with isotretinoin:a rare complication[J].J Sex Med,2013,10(10):2604. [42]Lee YH,Scharnitz TP,Muscat J,et al.Laboratory Monitoring During Isotretinoin Therapy for Acne:A Systematic Review and Meta-analysis[J].JAMA Dermatol,2016,152(1):35-44. [43]Hansen TJ,Lucking S,Miller JJ,et al.Standardized laboratory monitoring with use of isotretinoin in acne[J].J Am Acad Dermatol,2016,75(2):323-328. [44]Rao P,Bhat R,Nandakishore B,et al.Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe acne vulgaris[J].Indian J Dermatol,2014,59(3):316. [45]Boyraz N,Mustak PK.Comparison of the efficacies of intermittent and continuous low-dose isotretinoin regimens in the treatment of moderate acne vulgaris[J].Int J Dermatol,2013,52(10):1265-1267. [46]Owen CE.Treating acne with high-dose isotretinoin[J].JAMA,2014,311(20):2121-2122. [47]Zeitany AE,Bowers EV,Morrell DS.High-dose isotretinoin has lower impact on wallets:A cost analysis of dosing approaches[J].J Am Acad Dermatol,2016,74(1):174-176. [48]Rademaker M.Making sense of the effects of the cumulative dose of isotretinoin in acne vulgaris[J].Int J Dermatol,2016,55(5):518-523. [49]Tan J,Knezevic S,Boyal S,et al.Evaluation of Evidence for Acne Remission With Oral Isotretinoin Cumulative Dosing of 120-150 mg/kg[J].J Cutan Med Surg,2016,20(1):13-20. [50]Karadag AS,Ertugrul DT,Takci Z,et al.The effect of isotretinoin on retinol-binding protein 4,leptin,adiponectin and insulin resistance in acne vulgaris patients[J].Dermatology,2015,230(1):70-74. [51]Miller IM,Echeverria B,Torrelo A,et al.Infantile acne treated with oral isotretinoin[J].Pediatr Dermatol,2013,30(5):513-518. [52]Samycia M,Lam JM.Infantile acne[J].CMAJ,2016,188(17-18):E540. [53]de Lucas R,Moreno-Arias G,Perez-Lopez M,et al.Adherence to drug treatments and adjuvant barrier repair therapies are key factors for clinical improvement in mild to moderate acne:the ACTUO observational prospective multicenter cohort trial in 643 patients[J].BMC Dermatol,2015,15(1):1-6.

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更新日期/Last Update: 2018-07-01