[1]张明荣.孟鲁司特钠联合布地奈德治疗小儿哮喘的临床疗效分析[J].医学信息,2018,31(13):131-133.[doi:10.3969/j.issn.1006-1959.2018.13.038]
 ZHANG Ming-rong.Clinical Analysis of Montelukast Sodium Combined with Budesonide in the Treatment of Childhood Asthma[J].Journal of Medical Information,2018,31(13):131-133.[doi:10.3969/j.issn.1006-1959.2018.13.038]
点击复制

孟鲁司特钠联合布地奈德治疗小儿哮喘的临床疗效分析()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年13期
页码:
131-133
栏目:
药物与临床
出版日期:
2018-07-01

文章信息/Info

Title:
Clinical Analysis of Montelukast Sodium Combined with Budesonide in the Treatment of Childhood Asthma
文章编号:
1006-1959(2018)13-0131-03
作者:
张明荣
成都市武侯区人民医院小儿呼吸内科,四川 成都 610041
Author(s):
ZHANG Ming-rong
Department of Pediatric Respiratory Medicine,Wuhou District People’s Hospital,Chengdu 610041,Sichuan,China
关键词:
孟鲁司特钠布地奈德小儿哮喘
Keywords:
Key words:Montelukast sodiumBudesonideChildhood asthma
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2018.13.038
文献标志码:
A
摘要:
目的 探讨小儿哮喘应用孟鲁司特钠与布地奈德联合治疗的疗效。方法 选取本院儿科2014年7月~2015年7月接收治疗的110例哮喘患儿,随机分为甲组和乙组,各55例。甲组患儿单纯应用布地奈德进行治疗,乙组患儿在甲组治疗的同时联合应用孟鲁司特钠,对比两组哮喘患儿的肺功能、炎性情况以及临床疗效。结果 ①乙组治疗后的FEV1、FVC与PEF依次为(0.89±0.20)L、(0.83±0.19)L、(90.00±18.20)L/s,均分别高于甲组的(0.78±0.30)L、(0.65±0.20)L、(81.20±21.00)L/s,差异有统计学意义(P<0.05)。②乙组治疗后的hs-CRP、IL-6依次为(8.00±1.29)mg/L、(44.00±12.40)pg/ml,分别低于甲组的(11.30±2.00)mg/L、(95.68±16.55)pg/ml,差异有统计学意义(P<0.05)。③乙组治疗总有效率为90.91%,高于甲组的72.73%,差异有统计学意义(P<0.05)。结论 对哮喘患儿应用孟鲁司特钠与布地奈德联合治疗,有助于缓解呼吸道炎性症状、改善肺功能,促进临床疗效的进一步提升。
Abstract:
Abstract:Objective To evaluate the efficacy of montelukast sodium combined with budesonide in the treatment of childhood asthma. Methods 110 children with asthma received treatment from July 2014 to July 2015 were randomly divided into two groups:group A (55 cases)and group B(55 cases).Group A was treated with budesonide alone,group B was treated with montelukast sodium in combination with group A,and the pulmonary function,inflammatory status and clinical efficacy of two groups of asthmatic children were compared.Results ①After treatment,FEV1,FVC and PEF in group B were(0.89±0.20)L,(0.83±0.19)L,(90.00±18.20)L/s, respectively,higher than those in group A(0.78±0.30)L,(0.65±0.20)L,(81.20±21.00)L/s,respectively,the difference was statistically significant (P< 0.05).②After treatment,hs-CRPN,IL-6 in group B was (8.00±1.29)mg/L,(44.00±12.40)pg/ml,respectively,lower than that in group A(11.30 ±2.00)mg/L,(95.68 ±16.55)pg/ml,the difference was statistically significant (P<0.05).③The total effective rate of treatment in group B was 90.91%,which was higher than that in group A 72.73%,the difference was statistically significant(P<0.05). Conclusion The combined therapy of montelukast sodium and budesonide is helpful to relieve respiratory inflammatory symptoms, improve lung function and promote the further improvement of clinical efficacy in asthmatic children.

参考文献/References:

[1]潘凤娟,钟翠鸣,招清林.布地奈德和沙丁胺醇雾化吸入联合孟鲁司特治疗小儿哮喘的临床疗效观察[J].实用心脑肺血管病杂志,2015,23(02):131-132. [2]中华医学会呼吸病学分会哮喘学组.咳嗽的诊断与治疗指南(2015)[J].中华结核和呼吸杂志,2016,39(5):323-354. [3]任蕊.布地奈德气雾剂联合孟鲁司特治疗小儿哮喘的临床效果分析[J].中国继续医学教育,2016,8(22):167-168. [4]施安春.胶乳增强免疫比浊法和免疫层析法测定C反应蛋白的比较[J].西藏医药,2015,36(04):7-9. [5]陈昭宏.孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的临床疗效观察[J].吉林医学,2016,37(11):2765-2766. [6]路珉.孟鲁司特联合布地奈德治疗小儿哮喘疗效观察[J].医学信息,2014,27(14):286-286.

相似文献/References:

[1]李波.孟鲁司特钠联合酮替芬治疗小儿支气管炎的临床效果分析[J].医学信息,2018,31(02):130.[doi:10.3969/j.issn.1006-1959.2018.02.048]
 LI Bo.Clinical Analysis of Montelukast Sodium Combined With Ketotifen in the Treatment of Bronchitis in Children[J].Journal of Medical Information,2018,31(13):130.[doi:10.3969/j.issn.1006-1959.2018.02.048]
[2]马建娟.布地奈德联合异丙托溴铵雾化治疗COPD 急性加重期的效果评价[J].医学信息,2018,31(07):141.[doi:10.3969/j.issn.1006-1959.2018.07.048]
 MA Jian-juan.Efficacy Evaluation of Budesonide Combined with Ipratropium Bromide in Treatment of Acute Exacerbation of COPD[J].Journal of Medical Information,2018,31(13):141.[doi:10.3969/j.issn.1006-1959.2018.07.048]
[3]尹静华.孟鲁司特钠治疗小儿哮喘的临床有效性分析[J].医学信息,2018,31(09):138.[doi:10.3969/j.issn.1006-1959.2018.09.043]
 YIN Jing-hua.Clinical Efficacy of Montelukast Sodium in Children with Asthma[J].Journal of Medical Information,2018,31(13):138.[doi:10.3969/j.issn.1006-1959.2018.09.043]
[4]罗玉霞.舒适护理在布地奈德联合氨溴索雾化吸入治疗 慢阻肺急性发作患者的效果分析[J].医学信息,2018,31(12):179.[doi:10.3969/j.issn.1006-1959.2018.12.058]
 LUO Yu-xia.Analysis of the Effect of Comfortable Nursing in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients with Aerosolized Inhalation of Budesonide and Ambroxol[J].Journal of Medical Information,2018,31(13):179.[doi:10.3969/j.issn.1006-1959.2018.12.058]
[5]邱亚双.辛夷鼻炎丸联合布地奈德治疗变应性鼻炎的临床观察[J].医学信息,2019,32(03):158.[doi:10.3969/j.issn.1006-1959.2019.03.052]
 QIU Ya-shuang.Clinical Observation of Xinyi Biyan Wan Combined with Budesonide in Treating Allergic Rhinitis[J].Journal of Medical Information,2019,32(13):158.[doi:10.3969/j.issn.1006-1959.2019.03.052]
[6]王 瑜.布地奈德混悬液联合特布他林治疗小儿哮喘的效果[J].医学信息,2022,35(12):184.[doi:10.3969/j.issn.1006-1959.2022.12.047]
 WANG Yu.Effect of Budesonide Suspension Combined with Terbutaline in the Treatment of Pediatric Asthma[J].Journal of Medical Information,2022,35(13):184.[doi:10.3969/j.issn.1006-1959.2022.12.047]
[7]王 雪,章 晔,李宝华.孟鲁斯特钠片与异丙托溴铵和布地奈德混悬液雾化吸入对小儿呼吸道感染性咳嗽的临床疗效[J].医学信息,2022,35(12):190.[doi:10.3969/j.issn.1006-1959.2022.12.049]
 WANG Xue,ZHANG Ye,LI Bao-hua.Clinical Effect of Montelukast Sodium Tablets Combined with Ipratropine Bromide and Budesonide Mixed Suspension Atomization Inhalation on Children with Respiratory Tract Infection Cough[J].Journal of Medical Information,2022,35(13):190.[doi:10.3969/j.issn.1006-1959.2022.12.049]
[8]周 佳,柴明思.布地奈德、异丙托溴铵气雾剂联合雾化吸入治疗对肺气肿患者肺功能及血液相关指标的影响[J].医学信息,2019,32(09):151.[doi:10.3969/j.issn.1006-1959.2019.09.050]
 ZHOU Jia,CHAI Ming-si.Effects of Budesonide and Ipratropium Bromide Aerosol Combined with Nebulized Inhalation on Pulmonary Function and Blood Related Indexes in Patients with Emphysema[J].Journal of Medical Information,2019,32(13):151.[doi:10.3969/j.issn.1006-1959.2019.09.050]
[9]张 健.孟鲁司特钠联合氯雷他定治疗小儿过敏性紫癜的疗效及对炎性因子、免疫球蛋白水平的影响[J].医学信息,2022,35(15):107.[doi:10.3969/j.issn.1006-1959.2022.15.024]
 ZHANG Jian.Effect of Montelukast Sodium Combined with Loratadine in the Treatment of Anaphylactoid Purpura in Children and its Effect on Inflammatory Factors and Immunoglobulin Levels[J].Journal of Medical Information,2022,35(13):107.[doi:10.3969/j.issn.1006-1959.2022.15.024]
[10]刘江海.异丙托溴铵雾化吸入治疗慢阻肺急性加重期的临床疗效[J].医学信息,2019,32(20):150.[doi:10.3969/j.issn.1006-1959.2019.20.047]
 LIU Jiang-hai.Clinical Efficacy of Ipratropium Bromide Inhalation in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Journal of Medical Information,2019,32(13):150.[doi:10.3969/j.issn.1006-1959.2019.20.047]
[11]韦春峥,莫 彬,莫善圆,等.孟鲁司特钠联合布地奈德治疗儿童支气管哮喘合并变应性鼻炎的临床效果[J].医学信息,2019,32(20):142.[doi:10.3969/j.issn.1006-1959.2019.20.044]
 WEI Chun-zheng,MO Bin,MO Shan-yuan,et al.Clinical Effect of Montelukast Sodium Combined with Budesonide in the Treatment of Children with Bronchial Asthma Complicated with Allergic Rhinitis[J].Journal of Medical Information,2019,32(13):142.[doi:10.3969/j.issn.1006-1959.2019.20.044]
[12]甘 瀛.孟鲁司特钠联合布地奈德治疗小儿咳嗽变异性哮喘的疗效[J].医学信息,2019,32(12):150.[doi:10.3969/j.issn.1006-1959.2019.12.049]
 GAN Ying.Efficacy of Montelukast Sodium Combined with Budesonide in the Treatment of Cough Variant Asthma in Children[J].Journal of Medical Information,2019,32(13):150.[doi:10.3969/j.issn.1006-1959.2019.12.049]
[13]凌春艳.布地奈德气雾剂联合孟鲁司特钠治疗老年咳嗽变异性哮喘的疗效[J].医学信息,2020,33(07):144.[doi:10.3969/j.issn.1006-1959.2020.07.046]
 LING Chun-yan.Efficacy of Budesonide Aerosol Combined with Montelukast Sodium in the Treatment of Elderly Cough Variant Asthma[J].Journal of Medical Information,2020,33(13):144.[doi:10.3969/j.issn.1006-1959.2020.07.046]
[14]穆妮热·麦麦提吐孙,阿卜杜凯尤木·库尔班.孟鲁司特钠联合布地奈德治疗小儿支气管哮喘的疗效及对患儿肺功能、外周血嗜酸性粒细胞的影响[J].医学信息,2023,36(21):138.[doi:10.3969/j.issn.1006-1959.2023.21.032]
 EosinophilsMunige·McMetitosun,Abdolkayum·Kurbane.Efficacy of Montelukast Sodium Combined with Budesonide in the Treatment of Bronchial Asthma in Children and its Effect on Lung Function and Peripheral Blood[J].Journal of Medical Information,2023,36(13):138.[doi:10.3969/j.issn.1006-1959.2023.21.032]

更新日期/Last Update: 2018-07-01