[1]朱晓晓,张 顺,蔡 挺.镍暴露相关的肺癌发生分子机制研究[J].医学信息,2018,(17):4-7.[doi:10.3969/j.issn.1006-1959.2018.17.002]
 ZHU Xiao-xiao,ZHANG Shun,CAI Ting.Molecular Mechanism of Lung Cancer Related to Nickel Exposure[J].Medical Information,2018,(17):4-7.[doi:10.3969/j.issn.1006-1959.2018.17.002]
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镍暴露相关的肺癌发生分子机制研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年17期
页码:
4-7
栏目:
肺癌专题
出版日期:
2018-09-01

文章信息/Info

Title:
Molecular Mechanism of Lung Cancer Related to Nickel Exposure
文章编号:
1006-1959(2018)17-0004-04
作者:
朱晓晓1张 顺2蔡 挺2
1.宁波大学医学院,浙江 宁波 315000; 2.宁波市第二医院干细胞实验室,浙江 宁波 315010
Author(s):
ZHU Xiao-xiao1ZHANG Shun2CAI Ting2
1.School of Medicine,Ningbo University,Ningbo 315000,Zhejiang,China; 2.Stem Cell Laboratory,Ningbo Second Hospital,Ningbo 315010,Zhejiang,China
关键词:
肺癌凋亡自噬侵袭和转移增殖
Keywords:
Key words:NickelLung cancerApoptosisAutophagyInvasion and metastasisProliferation
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2018.17.002
文献标志码:
A
摘要:
人体镍及其化合物暴露主要是通过吸入和摄入,已有的流行病学研究,肺癌发病率与镍元素相关暴露有显著的相关性。然而,镍及其化合物可通过多种途径从多个方面作用于组织细胞,诱导肺癌发生的分子机制尚不明确。本文主要对镍及其化合物影响细胞凋亡、自噬、侵袭和转移、增殖等方面进行综述,进一步促进与镍相关的肺癌致病机制的深入研究。
Abstract:
Abstract:Exposure of human nickel and its compounds is mainly through inhalation and ingestion,and existing epidemiological studies have shown a significant correlation between lung cancer incidence and nickel-related exposure.However,nickel and its compounds can act on tissue cells in many ways through various ways,and the molecular mechanism of inducing lung cancer is still unclear.This review focuses on the effects of nickel and its compounds on apoptosis,autophagy,invasion and metastasis,and proliferation,and further promotes the in-depth study of the pathogenesis of nickel-related lung cancer.

参考文献/References:

[1]Berriault CJ,Lightfoot NE,Seilkop SK,et al.Injury mortality in a cohort of mining,smelting,and refining workers in Ontario[J].Arch Environ Occup Health,2017,72(4):220-230. [2]Pavela M,Uitti J,Pukkala E.Cancer incidence among copper smelting and nickel refining workers in Finland[J].American Journal of Industrial Medicine,2017,60(1):87-95. [3]Shan WU,Na BY,Quan PH,et al.Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers[J].Biomed Environ Sci,2015,28(9):679-682. [4]Lightfoot NE,Berriault CJ,Seilkop SK,et al.Non-respiratory mortality and cancer incidence in a cohort of Canadian nickel workers[J].Arch Environ Occup Health,2017,72(4):187-203. [5]Doll R,Morgan LG,Speizer FE.Cancers of the lung and nasal sinuses in nickel workers[J].British Journal of Cancer,1970,24(4):623-632. [6]Malhotra J,Sartori S,Brennan P,et al.Effect of Occupational Exposures on Lung Cancer Susceptibility:A Study of Gene-Environment Interaction Analysis[J].Cancer Epidemiol Biomarkers Prev,2015,24(3):570-579. [7]Chen K,Liao QL,Ma ZW,et al.Association of soil arsenic and nickel exposure with cancer mortality rates,a town-scale ecological study in Suzhou,China[J].Environmental Science&Pollution Research International,2015,22(7):5395-5404. [8]Yang ZP,Zhao Y,Huang F,et al.Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway[J].World Journal of Gastroenterology,2015,21(36):10385-10399. [9]Park S,Yong KL,Jung M,et al.Cellular Toxicity of Various Inhalable Metal Nanoparticles on Human Alveolar Epithelial Cells[J].Inhalation Toxicology,2007,19(1):59-65. [10]Zhao J,Bowman L,Zhang X,et al.Metallic nickel nano-and fine particles induce JB6 cell apoptosis through a caspase-8 AIF mediated cytochrome c-independent pathway[J].Journal of Nanobiotechnology,2009,7(1):2. [11]Siddiqui WA,Ahad A,Ahsan H.The mystery of BCL2 family:Bcl-2 proteins and apoptosis:an update[J].Archives of Toxicology,2015,89(3):289-317. [12]Berger S,Procko E,Margineantu D,et al.Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer[J].eLife,2016,2(5):20352. [13]Guo H,Cui H,Peng X,et al.Modulation of the PI3K Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride(NiCl2)[J].International Journal of Molecular Sciences,2015,16(9):22989-23011. [14]Singh K,Briggs JM.Functional Implications of the spectrum of BCL2 mutations in Lymphoma[J].Mutation Research/reviews in Mutation Research,2016(769):1-18. [15]Yang YX,Li XL,Wang L,et al.Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells[J].International Journal of Oncology,2013,43(3):936-946. [16]Castorina A,Giunta S.Mucin 1 (MUC1)signalling contributesto increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate[J].Biometals,2014,27(6):1149-1158. [17]Kalaivani P,Saranya S,Poornima P,et al.Biological evaluation of new nickel(II)metallates:Synthesis,DNA protein binding and mitochondrial mediated apoptosis in human lung cancer cells (A549)via ROS hypergeneration and depletion of cellular antioxidant pool[J].European Journal of Medicinal Chemistry,2014,82(16):584-599. [18]Pan J,Qingshan Chang,Xin Wang,et al.Reactive oxygen species-activated Akt ASK1 p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells[J].Chemical Research in Toxicology,2010,23(3):568-577. [19]Wang YF,Shyu HW,Chang YC,et al.Nickel(II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS-and mitochondria-mediated pathway[J].Toxicol Appl Pharmacol,2012,259(2):177-186. [20]Xue R,Meng Q,Lu D,et al.Mitofusin2 Induces Cell Autophagy of Pancreatic Cancer through Inhibiting the PI3K Aktm TOR Signaling Pathway[J].Oxidative Medicine&Cellular Longevity,2018,6(26):2798070. [21]Zhou F,Li YH,Wang JJ,et al.Endoplasmic reticulum stress could induce autophagy and apoptosis and enhance chemotherapy sensitivity in human esophageal cancer EC9706 cells by mediating PI3K Akt mTOR signaling pathway[J].International Society for Oncodevelopmental Biology&Medicine,2017,39(6):1010428317705748. [22]Mowers EE,Sharifi MN,Macleod KF.Functions of autophagy in the tumor microenvironment and cancer metastasis[J].Febs Journal,2018,285(10):1751-1766. [23]Xu DW,Zhang GQ,Wang ZW,et al.Autophagy in tumorigenesis and cancer treatment[J].Asian Pacific Journal of Cancer Prevention Apjcp,2015,16(6):2167. [24]Choi AM,Ryter SW,Levine B.Autophagy in human health and disease[J].New England Journal of Medicine,2013,368(7):651-662. [25]Prietodomínguez N,Ordóez R,Fernández A,et al.Modulation of Autophagy by Sorafenib:Effects on Treatment Response[J].Frontiers in Pharmacology,2016,7(7):151. [26]Ozpolat B,Benbrook DM.Targeting autophagy in cancer management-strategies and developments[J].Cancer Management&Research,2015,7:291-299. [27]张岚,杨磊,吕嘉春.结晶型硫化镍通过自噬途径诱导16HBE细胞恶性转化癌变[J].基因组学与应用生物学,2012,31(3):222-225. [28]Huang H,Zhu J,Li Y,et al.Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells[J].Autophagy,2016,12(10):1687-1703. [29]Wang J,Liu Z,Hu T,et al.Nrf2 promotes progression of non-small cell lung cancer through activating autophagy[J].Cell Cycle,2017,16(11):1053-1062. [30]Son YO,Pratheeshkumar P,Divya SP,et al.Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells[J].Journal of Biological Chemistry,2017,292(20):8315-8330. [31]Kang YT,Hsu WC,Wu CH,et al.Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2,activating lipocalin-2,in human bronchial epithelial cells[J].Oncotarget,2017,8(62):105536-105552. [32]Chiou YH,Liou SH,Wong RH,et al.Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression[J].Toxicology Letters,2015,237(1):46-54. [33]Xu Z,Ren T,Xiao C,et al.Nickel promotes the invasive potential of human lung cancer cells via TLR4 MyD88 signaling[J].Toxicology,2011,285(2):25-30. [34]Kim HS,Kim YJ,Seo YR.An Overview of Carcinogenic Heavy Metal:Molecular Toxicity Mechanism and Prevention[J].Journal of Cancer Prevention,2015,20(4):232-240. [35]王琛,陈亚明.镍离子诱导小鼠成纤维细胞氧化应激反应的实验研究[J].口腔生物医学,2013,4(3):121-124. [36]Cameron KS,Buchner V,Tchounwou PB.Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity:A literature review[J].Reviews on Environmental Health,2011,26(2):81-92. [37]Bucchianico SD,Gliga AR,kerlund E,et al.Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells[J].Particle&Fibre Toxicology 2018,15(1):32. [38]韦乐华,孙婧媛,任慧文,等.镍离子对人血管内皮细胞增殖影响的研究[J].广州化工,2016,11(10):70-72.

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更新日期/Last Update: 2018-09-01