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Molecular Mechanism of Lung Cancer Related to Nickel Exposure
朱晓晓1张 顺2蔡 挺2
1.宁波大学医学院,浙江 宁波 315000; 2.宁波市第二医院干细胞实验室,浙江 宁波 315010
ZHU Xiao-xiao1ZHANG Shun2CAI Ting2
1.School of Medicine,Ningbo University,Ningbo 315000,Zhejiang,China; 2.Stem Cell Laboratory,Ningbo Second Hospital,Ningbo 315010,Zhejiang,China
Key words:NickelLung cancerApoptosisAutophagyInvasion and metastasisProliferation
Abstract:Exposure of human nickel and its compounds is mainly through inhalation and ingestion,and existing epidemiological studies have shown a significant correlation between lung cancer incidence and nickel-related exposure.However,nickel and its compounds can act on tissue cells in many ways through various ways,and the molecular mechanism of inducing lung cancer is still unclear.This review focuses on the effects of nickel and its compounds on apoptosis,autophagy,invasion and metastasis,and proliferation,and further promotes the in-depth study of the pathogenesis of nickel-related lung cancer.


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更新日期/Last Update: 2018-09-01