[1]李春磊,裴艳志,邹志田,等.非小细胞肺癌组织中趋化因子受体CCR7的 表达及其临床意义[J].医学信息,2018,31(17):14-16.[doi:10.3969/j.issn.1006-1959.2018.17.004]
　LI Chun-lei,PEI Yan-zhi,ZOU Zhi-tian,et al.Expression of Chemokine Receptor CCR7 in Non-small Cell Lung Cancer and its Clinical Significance[J].Journal of Medical Information,2018,31(17):14-16.[doi:10.3969/j.issn.1006-1959.2018.17.004]
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非小细胞肺癌组织中趋化因子受体CCR7的 表达及其临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年17期
页码:
14-16
栏目:
出版日期:
2018-09-01

文章信息/Info

Title:
Expression of Chemokine Receptor CCR7 in Non-small Cell Lung Cancer and its Clinical Significance
文章编号:
1006-1959（2018）17-0014-03
作者:
李春磊; 裴艳志; 邹志田; 高 磊; 路 通; 凡 航; 朱晓峰
佳木斯大学附属第一医院胸外科，黑龙江 佳木斯 154000
Author(s):
LI Chun-lei; PEI Yan-zhi; ZOU Zhi-tian; GAO Lei; LU Tong; FAN Hang; ZHU Xiao-feng
Department of Thoracic Surgery,the First Affiliated Hospital of Jiamusi University,Jiamusi 154000,Heilongjiang,China
关键词:
非小细胞肺癌; CCR7; 淋巴结转移
Keywords:
Key words：Non-small cell lung cancer; CCR7; Lymph node metastasis
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2018.17.004
文献标志码:
A
摘要:
目的 研究CCR7在NSCLC中的表达情况，探讨其与NSCLC的临床病理关系。方法 采取链霉素抗生物素蛋白-过氧化物酶免疫组化法检测36例非小细胞肺癌组织、5例正常肺组织 CCR7的表达情况及肺癌组织 D2-40的表达情况。结果 CCR7主要表达在细胞膜及细胞质，36例组织标本中29例阳性表达，阳性率为80.56%；正常肺组织的阳性率为10.00%。癌组织淋巴结阳性标本中 CCR7阳性率为84.21%，阴性标本阳性率为52.94%（P＜0.05）。结论 CCR7在肺癌组织中高表达，并随着TNM分期的提高，CCR7的表达也逐渐提高。并且CCR7高表达的癌组织样本中D2-40也呈现高表达。NSCLC淋巴结转移与癌组织中的CC7高表达关联密切，可能为今后预测NSCLC患者预后及治疗提供有力的理论依据。
Abstract:
Abstract：Objective To investigate the expression of CCR7 in NSCLC and to explore its clinicopathological relationship with NSCLC. Methods The expression of CCR7 in 36 cases of non-small cell lung cancer tissues and 5 normal lung tissues and the expression of D2-40 in lung cancer tissues were detected by streptomycin avidin-peroxidase immunohistochemistry.Results CCR7 was mainly expressed in cell membrane and cytoplasm,and 29 cases were positively expressed in 36 tissue samples,the positive rate was 80.56%; the positive rate of normal lung tissue was 10.00%.The positive rate of CCR7 in cancer tissue-positive specimens was 84.21%,and the positive rate in negative specimens was 52.94%(P<0.05).Conclusion CCR7 is highly expressed in lung cancer tissues,and the expression of CCR7 is gradually increased with the increase of TNM staging.And D2-40 also showed high expression in cancer tissue samples with high CCR7 expression.NSCLC lymph node metastasis is closely related to the high expression of CC7 in cancer tissues, which may provide a powerful theoretical basis for predicting the prognosis and treatment of patients with NSCLC.

参考文献/References:

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更新日期/Last Update: 2018-09-01