[1]樊 毅.帕金森病嗅觉改变的相关性研究[J].医学信息,2018,(17):95-97.[doi:10.3969/j.issn.1006-1959.2018.17.029]
 FAN Yi.Correlation Study of Olfactory Changes in Parkinson's Disease[J].Medical Information,2018,(17):95-97.[doi:10.3969/j.issn.1006-1959.2018.17.029]
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帕金森病嗅觉改变的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年17期
页码:
95-97
栏目:
临床研究
出版日期:
2018-09-01

文章信息/Info

Title:
Correlation Study of Olfactory Changes in Parkinson's Disease
文章编号:
1006-1959(2018)17-0095-03
作者:
樊 毅
西安市阎良区中医医院内科,陕西 西安 710089
Author(s):
FAN Yi
Department of Internal Medicine,Xi'an Yanliang District Hospital of Traditional Chinese Medicine,Xi'an 710089,Shaanxi,China
关键词:
帕金森病嗅觉障碍简易嗅觉检测
Keywords:
Key words:Parkinson's diseaseOlfactory disorderSimple olfactory detection
分类号:
R742.5
DOI:
10.3969/j.issn.1006-1959.2018.17.029
文献标志码:
A
摘要:
目的 探讨帕金森病患者嗅觉功能改变及其与病程、病情和年龄的关系以及可能对帕金森病诊断的价值。方法 选取我院2014年3 月~2017年8月帕金森病住院患者41例为病例组,选择同期住院患者健康家属41例为对照组,应用简易嗅觉测定的方法分别对病例组和对照组进行嗅觉功能进行评估,比较两组的嗅觉功能,分析年龄,病程,Hoehn-Yahr(H-Y)分级与嗅觉的相关性。结果 病例组嗅觉障碍的发生率为85.36%,高于对照组26.82%,统计学意义显著(P<0.01);在Hoehn-Yahr分级Ⅰ~Ⅱ级嗅觉障碍发生率高于Ⅳ级,差异有统计学意义(P<0.05);其与年龄、病程无关(P>0.05)。结论 帕金森病患者存在嗅觉功能异常,其与病程、年龄无关,与病情相关。
Abstract:
Abstract:Objective To investigate the changes of olfactory function in patients with Parkinson's disease and their relationship with disease course, condition and age,and the value of possible diagnosis of Parkinson's disease.Methods A total of 41 hospitalized patients with Parkinson's disease from March 2014 to August 2017 were selected as the case group.41 healthy family members of the same period were selected as the control group.The simple olfactory measurement method was used to control the case group and the control group.The olfactory function was evaluated,the olfactory function of the two groups was compared,and the age,duration of disease,Hoehn-Yahr(H-Y)grading and olfactory correlation were analyzed.Results The incidence of olfactory disturbance in the case group was 85.36%,which was higher than that in the control group 26.82%,the statistical significance was significant(P<0.01);the incidence of olfactory disturbance in Hoehn-Yahr grade I~II was higher than that in grade IV,the difference was statistically significant(P<0.05);it was not related to age and duration(P>0.05).Conclusion Patients with Parkinson's disease have abnormal olfactory function,which is not related to the course of disease and age,and is related to the condition.

参考文献/References:

[1]庞灵思,张扬,管得宁.帕金森病的嗅觉障碍[J].医学综述,2015,21(7):1237-1240. [2]万学红,卢雪峰.诊断学[M].第8版.北京:人民卫生出版社,2013:218. [3]刘宇翔,刘振华,张峪函.帕金森病异动症发病的相关因素分析[J].中国现代医学杂志,2016,26(2):121-126. [4]檀国祥,许启伍,丁婷,等.早期帕金森病病人嗅觉障碍的相关性分析[J].蚌埠医学院学报,2017,42(3):339-341. [5]郭莎莎,李玲,戴艳,等.早期帕金森病患者嗅觉与认知功能的相关性分析[J].中华医学杂志,2015,95(7):489. [6]陈泽颉,王瑞丹,张威.帕金森病嗅觉障碍机制的研究进展[J].中国神经免疫学和神经病学杂志,2017,24(1):48-52.

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更新日期/Last Update: 2018-09-01