[1]朱华东,左 兴,高李华.左乙拉西坦联合托吡酯治疗Lennox-Gastaut综合征 疗效观察[J].医学信息,2018,(17):122-124.[doi:10.3969/j.issn.1006-1959.2018.17.037]
 ZHU Hua-dong,ZUO Xing,GAO Li-hua.Therapeutic Effect of Levetiracetam Combined with Topiramate on Lennox-gastaut Syndrome[J].Medical Information,2018,(17):122-124.[doi:10.3969/j.issn.1006-1959.2018.17.037]
点击复制

左乙拉西坦联合托吡酯治疗Lennox-Gastaut综合征 疗效观察()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年17期
页码:
122-124
栏目:
药物与临床
出版日期:
2018-09-01

文章信息/Info

Title:
Therapeutic Effect of Levetiracetam Combined with Topiramate on Lennox-gastaut Syndrome
文章编号:
1006-1959(2018)17-0122-03
作者:
朱华东1左 兴2高李华1
1.赣州市人民医院新院儿科,江西 赣州 341000; 2.高安市人民医院,江西 高安 330800
Author(s):
ZHU Hua-dong1ZUO Xing2GAO Li-hua1
1.New Hospital Pediatrics,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China; 2.Gao'an People's Hospital,Gao'an 330800,Jiangxi,China
关键词:
左乙拉西坦托吡酯Lennox-Gastaut综合征儿童
Keywords:
Key words:LevetiracetamTopiramateLennox-gastaut syndromeChildren
分类号:
R742.1
DOI:
10.3969/j.issn.1006-1959.2018.17.037
文献标志码:
A
摘要:
目的 观察左乙拉西坦联合托吡酯治疗儿童难治性癫痫综合征的临床效果。方法 选取我院2015年6月~2017年12月收治的儿童难治性癫痫综合征患儿40例,采取数字随机表法分为治疗组与对照组,每组20例。治疗组患儿给予左乙拉西坦联合托吡酯干预,对照组患儿给予左乙拉西坦单药干预,治疗8周后比较两组患儿的临床疗效。比较治疗组前后患儿头颅磁共振波谱、脑电图棘慢波指数的变化,同时采用中国修订版韦氏儿童智力量表(WISC-R)作为评定工具,对治疗组前后儿童进行智力测试及评定。结果 治疗组临床有效率为90.00%,高于对照组60.00%,统计学意义显著(P<0.01)。治疗组患儿头颅磁共振波谱NAA(N-乙酰天门冬氨酸)峰值升高,脑电图棘慢波指数较治疗前减少,患儿认知功能改善,统计学意义显著(P<0.01)。结论 治疗能够降低脑电图棘慢波指数、提升NAA/Cho+Cr、NAA/Cho及NAA/Cr比值,改善患儿认知功能,临床疗效显著,为临床提供参考。
Abstract:
Abstract:Objective To observe the clinical effect of levetiracetam combined with topiramate in the treatment of refractory epilepsy syndrome in children.Methods A total of 40 children with refractory epilepsy syndrome admitted to our hospital from June 2015 to December 2017 were enrolled.The patients were divided into treatment group and control group by digital random table method,20 cases in each group.The patients in the treatment group were treated with levetiracetam plus topiramate,and the children in the control group were given levetiracetam alone.After 8 weeks of treatment,the clinical effects of the two groups were compared.The changes of head magnetic resonance spectroscopy and EEG spine slow wave index were compared before and after treatment.The Chinese version of Wechschild Intelligence Scale(WISC-R)was used as the assessment tool to test the intelligence of children before and after treatment. assessment.Results The clinical effective rate of the treatment group was 90.00%,which was higher than that of the control group 60.00%,the statistical significance was significant(P<0.01).The peak value of brain magnetic resonance spectroscopy NAA(N-acetylaspartate)increased,the spike-slow wave index of electroencephalogram decreased,the cognitive function of the children improved,the statistical significance was significant(P<0.01).Conclusion Treatment can reduce the electroencephalogram slow wave index,improve the ratio of NAA/Cho+Cr,NAA/Cho and NAA/Cr,improve the cognitive function of children,and have clinical curative effect,which provides a reference for clinical.

参考文献/References:

[1]郭爱芳,董琰,庞保东.69例儿童难治性癫痫的临床特点分析[J].中国小儿急救医学,2016,12(12):856-859. [2]李振宏,黄郁波,黄涛.左乙拉西坦单药治疗Lennox-Gastaut综合征的疗效观察[J].医学信息,2017,30(14):65-67. [3]杨琳.难治性癫痫的定义和治疗选择[J].中华实用儿科临床杂志,2016,31(12):887-890. [4]陈书远.左乙拉西坦治疗儿童癫痫的疗效与安全性分析[J].中外医学研究,2014,12(4):120-121. [5]陈娇,刘晓鸣,岳璇.左乙拉西坦添加治疗儿童难治性癫痫的临床疗效及安全性[J].中华临床医师杂志(电子版),2014(7):138-140. [6]杨柳,高丽,栾莹.不同药物治疗伴中央-颞区棘波的儿童良性癫痫对比研究[J].医药论坛杂志,2017(9):21-23. [7]胡丹丹,麦坚凝,杨思达.左乙拉西坦治疗和奥卡西平治疗儿童癫痫临床疗效对比[J].中国现代医生,2014(52):34-36. [8]康庆云,杨理明,陈波.左乙拉西坦添加儿童额叶癫痫58临床分析[J].中南药学,2016(12):1390-1393. [9]冯雪菲,肖农.拉西坦治疗不同年龄癫痫患儿的长程有效性及耐受性观察:210例报道[J].解放军医学杂志,2014,39(4):324-328. [10]张雁,黄高贵,刘春明.发作间期痫样放电对脑损伤婴幼儿认知发育的影响研究[J].心理医生,2016,22(29):265-266. [11]李倩.左乙拉西坦治疗原发性癫痫的临床疗效及其对生活质量的影响[J].四川医学,2015,36(01):75-77. [12]王冰,王敏,张琛,等.左乙拉西坦的神经保护作用研究进展[J].医学综述,2017,23(24):4960-4964. [13]季茉.左乙拉西坦治疗小儿癫痫临床疗效及对脑电图、智力改善作用[J].临床军医杂志,2017,45(8):865-867.

更新日期/Last Update: 2018-09-01