[1]王 会.吸入型糖皮质激素治疗儿童哮喘有效性与安全性的临床研究[J].医学信息,2018,31(17):128-129.[doi:10.3969/j.issn.1006-1959.2018.17.039]
　WANG Hui.Clinical Study on the Efficacy and Safety of Inhaled Corticosteroids in Children with Asthma[J].Journal of Medical Information,2018,31(17):128-129.[doi:10.3969/j.issn.1006-1959.2018.17.039]
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吸入型糖皮质激素治疗儿童哮喘有效性与安全性的临床研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年17期
页码:
128-129
栏目:
药物与临床
出版日期:
2018-09-01

文章信息/Info

Title:
Clinical Study on the Efficacy and Safety of Inhaled Corticosteroids in Children with Asthma
文章编号:
1006-1959（2018）17-0128-02
作者:
王 会1; 2
1.天津市河东区人民医院预防科，天津 300011； 2.天津市河东区春华街社区卫生服务中心，天津 300011
Author(s):
WANG Hui1; 2
1.Department of Preventive Medicine,Hedong District People's Hospital,Tianjin 300011,China; 2.Chunhua Street Community Health Service Center,Hedong District,Tianjin 300011,China
关键词:
吸入型糖皮质激素; 儿童哮喘; 肺功能指标
Keywords:
Key words：Inhaled corticosteroids; Childhood asthma; Pulmonary function indicators
分类号:
R725.6
DOI:
10.3969/j.issn.1006-1959.2018.17.039
文献标志码:
A
摘要:
目的 研究吸入型糖皮质激素治疗儿童哮喘的有效性与安全性。方法 回顾分析在我院接受治疗的96例哮喘儿童临床资料，随机分为对照组和治疗组，每组48例。取同期健康儿童40例为正常组。对照组口服醋酸泼尼松片治疗，治疗组雾化吸入布地奈德治疗，对比两组患儿治疗总有效率、肺功能指标、临床症状消退时间，以及吸入糖皮质激素对患儿身高、体重的影响。结果 治疗组治疗总有效率为97.87%，高于对照组的80.85%，差异有统计学意义（P＜0.05）；治疗组VCmax、FEV1、FEV1/FVC改善优于对照组，差异有统计学意义（P＜0.05）；治疗组咳嗽、憋喘、哮鸣音消退时间短于对照组，差异有统计学意义（P＜0.05）；治疗后，治疗组患儿身高、体重与正常组对比，差异无统计学意义（P＞0.05）。结论 吸入型糖皮质激素治疗儿童哮喘疗效确切，可快速减轻临床症状，改善肺功能，且对患者无不良影响。
Abstract:
Abstract：Objective To study the efficacy and safety of inhaled corticosteroids in the treatment of asthma in children.Methods The clinical data of 96 children with asthma who were treated in our hospital were retrospectively analyzed and randomly divided into control group and treatment group,48 cases in each group.40 healthy children in the same period were taken as normal group.The control group was treated with oral prednisone acetate.The treatment group was treated with aerosolized budesonide.The total effective rate of treatment,lung function index,time of clinical symptom regression,and the effect of inhaled corticosteroids on height and weight of children were compared.Results The total effective rate of treatment group was 97.87%,which was higher than that of the control group 80.85%,the difference was statistically significant(P<0.05).The improvement of VCmax,FEV1 and FEV1/FVC in the treatment group was better than that of the control group,the difference was statistically significant(P<0.05);the treatment group had shorter cough, asthma and wheezing time than the control group,the difference was statistically significant(P<0.05),after treatment,there was no significant difference in height and weight between the treatment group and the normal group(P>0.05).Conclusion Inhaled corticosteroids are effective in the treatment of children with asthma,which can quickly alleviate clinical symptoms,improve lung function,and have no adverse effects on patients.

参考文献/References:

[1]吕有道,张本金.布地奈德混悬液雾化吸入治疗儿童哮喘急性发作的疗效观察[J].中华妇幼临床医学杂志(电子版),2012,8(3):326-328. [2]韩连书,戴家熊.糖皮质激素防治儿童哮喘进展[J].临床儿科杂志,2013,14(5):347. [3]张洁.糖皮质激素吸入治疗儿童轻中度持续性哮喘合并变应性鼻炎的探讨[J].医学信息,2014,27(13):442. [4]方成波.儿童支气管哮喘急性发作雾化吸入布地奈德和可必特的疗效观察[J].广西医科大学学报,2012,29(3):452-453.

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更新日期/Last Update: 2018-09-01