[1]李德君,李慧君.来曲唑联合苍附导痰汤治疗多囊卵巢综合征不孕症患者的 临床观察[J].医学信息,2018,(17):137-139,142.[doi:10.3969/j.issn.1006-1959.2018.17.043]
 LI De-jun,LI Hui-jun.Clinical Observation of Letrozole Combined with Cangfu Daotan Decoction in the Treatment of Infertility Patients with Polycystic Ovary Syndrome[J].Medical Information,2018,(17):137-139,142.[doi:10.3969/j.issn.1006-1959.2018.17.043]
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来曲唑联合苍附导痰汤治疗多囊卵巢综合征不孕症患者的 临床观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年17期
页码:
137-139,142
栏目:
中医中药
出版日期:
2018-09-01

文章信息/Info

Title:
Clinical Observation of Letrozole Combined with Cangfu Daotan Decoction in the Treatment of Infertility Patients with Polycystic Ovary Syndrome
文章编号:
1006-1959(2018)17-0137-04
作者:
李德君1李慧君2
1.新疆佳音医院中西医结合科,新疆 乌鲁木齐 830001; 2.新疆自治区妇幼保健院,新疆 乌鲁木齐 830001
Author(s):
LI De-jun1LI Hui-jun2
1.Department of Integrated Traditional Chinese and Western Medicine,Xinjiang Jiayin Hospital,Urumqi 830001,Xinjiang,China; 2.Maternal and Child Health Hospital of Xinjiang Autonomous Region,Urumqi 830001,Xinjiang,China
关键词:
来曲唑苍附导痰汤多囊卵巢综合征不孕促排卵
Keywords:
Key words:LetrozoleCangfu Daotan decoctionPolycystic ovary syndromeInfertilityOvulation promoting
分类号:
R711.6
DOI:
10.3969/j.issn.1006-1959.2018.17.043
文献标志码:
A
摘要:
目的 探讨来曲唑、苍附导痰汤联合治疗多囊卵巢综合征不孕患者的临床效果。方法 选取我院2015年1月~2016年12月收治的多囊卵巢综合征患者248例,随机双盲法分为试验组和对照组,每组124例。对照组采用口服来曲唑治疗,试验组在对照组治疗基础上服用苍附导痰汤治疗。治疗后观察两组排卵、卵泡未破黄素化综合征(LUFS)和卵巢过度刺激综合征(OHSS)的发生情况,计算各组妊娠率。结果 治疗后试验组排卵数、优势卵泡数分别为(6.23±1.79)个、(6.01±1.83)个,高于对照组的(4.25±0.71)个、(3.93±0.56)个,差异有统计学意义(P<0.05),随访1年后试验组妊娠率为36.29%,高于对照组的25.00%,差异有统计学意义(P<0.05);试验组LUFS、OHSS发生率分别为9.67%、0.81%,低于对照组的27.42%、4.84%,差异有统计学意义(P<0.05)。结论 来曲唑联合苍附导痰汤能有效促进PCOS患者排卵,增加优势卵泡数,提高妊娠率。
Abstract:
Abstract:Objective To investigate the clinical effects of letrozole and Cangfu Daotan decoction in the treatment of infertility patients with polycystic ovary syndrome.Methods A total of 248 patients with polycystic ovary syndrome admitted to our hospital from January 2015 to December 2016 were enrolled.The patients were randomly divided into the experimental group and the control group,with 124 patients in each group.The control group was treated with oral letrozole,and the experimental group was treated with Cangfu Daotan decoction on the basis of the control group.After treatment,the incidence of ovulation,follicular unbreaking luteinization syndrome(LUFS)and ovarian hyperstimulation syndrome(OHSS)were observed,and the pregnancy rate of each group was calculated.Results After treatment,the number of ovulation and the number of dominant follicles in the experimental group were(6.23±1.79)and(6.01±1.83),which were higher than those in the control group(4.25±0.71)and(3.93±0.56),the difference was statistically significant(P<0.05),the pregnancy rate of the experimental group was 36.29% after 1 year of follow-up,which was higher than that of the control group 25.00%,the difference was statistically significant(P<0.05).The incidence of LUFS and OHSS in the experimental group were 9.67% and 0.81 respectively lower than 27.42% and 4.84% of the control group,the difference was statistically significant(P<0.05). Conclusion Letrozole combined with Cangfu Daotan decoction can effectively promote ovulation in PCOS patients,increase the number of dominant follicles,and increase the pregnancy rate.

参考文献/References:

[1]何晓彤,孟祥雯等.多囊卵巢综合征病因与发病机制的研究进展[J].中国妇幼保健,2017,32(7):1588-1591. [2]Ujvari D,Hulchiy M,Calaby A,et al.Lifestyle intervention up-regulates gene and protein levels of molecules involved in insulin signaling in the endometrium of overweight obese women with polycystic ovary syndrome[J].Hum Reprod,2014,29(7):1526-1535. [3]钟文明,宁伶俐,刘晓娟.育龄妇女人群多囊卵巢综合征发病危险因素调查分析[J].中国医院统计,2016,23(6):186-189. [4]全国妇科内分泌新进展学术研讨会卫生部.多囊卵巢综合征诊断标准和治疗规范[C].全国妇科内分泌新进展研讨会论文集,2012:19-24. [5]刘伟信,曾琴,徐红.卵巢过度刺激综合征防治研究进展[J].中国计划生育和妇产科,2017,9(1):20-23. [6]吴美娟.克罗米芬联合尿促性素治疗多囊卵巢综合征患者78 例[J].包头医学院学报,2016,32(9):60-61. [7]严永旭,张娣,胡卫华.曲普瑞林与HCG联合应用于PCOS患者成熟卵泡“扳机”的临床分析[J].皖南医学院学报,2015:34(3):226-229. [8]Nahuis MJ,Weiss NS,Van Der Veen F,et al.The M-OVIN study:does switching treatment to FSH and/or IUI lead to higher pregnancy rates in a subset of women with world health organization type II anovulation not conceiving after six ovulatory cycles with clomiphene citrate-a randomised controlled trial[J].BMC Womens Health,2013,13(1):42-48. [9]Ray CA,Chatterjee S.Frozen embryo transfer:the present practice and beyond[J].J Basic Clin Physiol Phnmcol,2013,24(2):125-130. [10]Legro RS.Letrozole versus clomiphene for infertility in the polycystic ovary syndrome[J].New Engl J Med,2014,371(2):119-129. [11]王燕,王春莲,员相冰,等.来曲唑与尿促性素在多囊卵巢综合征不孕患者促排卵中的应用[J].医学研究杂志,2017,46(8):160-163. [12]张艳.中药苍附导痰汤对肥胖型多囊卵巢综合征激素及脂代谢的影响研究[J].黑龙江医药,2017,30(6):1293-1295. [13]潘爱珍,陈克芳,侯祥平,等.苍附导痰汤对肥胖型多囊卵巢综合征大鼠的瘦素、脂联素水平及胰岛素敏感指数的影响[J].中医临床研究,2015,7(1):4-6. [14]李杏英,杨勤,王琪.苍附导痰汤联合氯米芬对多囊卵巢综合征合并不孕症患者性激素水平及子宫内膜容受性的影响[J].中国药房,2017,28(26):3698-3701. [15]王慧颖,林喧.加减苍附导痰汤调控痰湿阻滞型多囊卵巢综合征患者子宫内膜容受性研究[J].湖南中医药大学学报,2014,34(6):31-34. [16]曾小吉.苍附导痰汤在治疗多囊卵巢综合征中的可行性研究[J].中国临床研究,2015,7(19):1674-7860.

更新日期/Last Update: 2018-09-01