[1]刘小红.长效胰岛素联合口服降糖药治疗2型糖尿病的 疗效与安全性评价[J].医学信息,2018,31(18):121-123.[doi:10.3969/j.issn.1006-1959.2018.18.038]
　LIU Xiao-hong.Efficacy and Safety of Long Acting Insulin Combined with Oral Hypoglycemic Agents in Treatment of Type 2 Diabetes Mellitus[J].Journal of Medical Information,2018,31(18):121-123.[doi:10.3969/j.issn.1006-1959.2018.18.038]
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长效胰岛素联合口服降糖药治疗2型糖尿病的 疗效与安全性评价()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年18期
页码:
121-123
栏目:
药物与临床
出版日期:
2018-09-15

文章信息/Info

Title:
Efficacy and Safety of Long Acting Insulin Combined with Oral Hypoglycemic Agents in Treatment of Type 2 Diabetes Mellitus
文章编号:
1006-1959（2018）18-0121-03
作者:
刘小红
江西省九江彭泽县中医院药剂科，江西 彭泽 332700
Author(s):
LIU Xiao-hong
Department of Pharmacy,Pengze County Hospital of Traditional Chinese Medicine,Pengze 332700,Jiangxi,China
关键词:
2型糖尿病; 格列本脲片; 长效胰岛素
Keywords:
Key words：Type 2 diabetes mellitus; Glibenclamide tablets; Long acting insulin
分类号:
R587.1
DOI:
10.3969/j.issn.1006-1959.2018.18.038
文献标志码:
A
摘要:
目的 探究对2型糖尿病患者采用长效胰岛素联合口服降糖药治疗的效果。方法 抽取在我院接受治疗的2型糖尿病患者78例，使用电脑随机数字表法分为对照组和治疗组，各39例，对照组予以常规口服降糖药物治疗，治疗组在此基础上联合长效胰岛素进行治疗，比较两组患者的空腹血糖、餐后2 h血糖、糖化血红蛋白、尿微量改善情况及不良反应发生率。结果 治疗后，治疗组患者的尿微量（30.57±1.67）kg/m3、糖化血红蛋白（6.32±0.35）%及空腹血糖值（6.52±0.42）mmol/L、餐后2 h血糖值（10.68±0.87）mmol/L改善情况优于对照组的尿微量（26.31±2.85）kg/m3、糖化血红蛋白（9.04±1.45）%、空腹血糖值（8.02±0.78）mmol/L、餐后2 h血糖值（12.63±1.21）mmol/L，差异均有统计学意义（P＜0.05）；治疗组患者经药物治疗后的不良反应发生率为2.56%，低于对照组的20.51%，差异有统计学意义（P＜0.05）。结论 对2型糖尿病患者采用口服降糖药联合长效胰岛素进行治疗，能有效促进患者机体血糖得到调节与提升血糖控制率，且安全性高。
Abstract:
Abstract：Objective To investigate the effect of long acting insulin combined with oral hypoglycemic drugs on type 2 diabetes mellitus.Methods 78 patients with type 2 diabetes mellitus were randomly divided into control group and treatment group,39 cases in each group.The control group was treated with routine oral hypoglycemic drugs,and the treatment group was treated with long acting insulin.Fasting blood glucose,2h postprandial blood glucose,glycosylated hemoglobin,microaluria improvement and incidence of adverse reactions were compared between the two groups.Results After treatment,the urine volume of the treatment group was (30.57±1.67)kg/m3,glycated hemoglobin(6.32±0.35)%,fasting blood glucose(6.52±0.42)mmol/L,the improvement of blood glucose level (10.68±0.87)mmol/L after 2h was better than that of the control group urine trace(26.31±2.85)kg/m3,glycated hemoglobin(9.04±1.45)%,fasting blood glucose(8.02±0.78)mmol/L,2h postprandial blood glucose(12.63±1.21)mmol/L,the difference was statistically significant(P<0.05);the incidence of adverse reactions after treatment with patients in the treatment group was 2.56%,lower than the control group of 20.51%,the difference was statistically significant(P<0.05).Conclusion The treatment of type 2 diabetes mellitus patients with oral hypoglycemic agents combined with long acting insulin can effectively promote the regulation of blood glucose in patients and improve blood sugar control rate,and it is safe.

参考文献/References:


[1]汤小峰,蒋艺兰,鲍家军.地特胰岛素对口服二甲双胍血糖控制不佳的2型糖尿病患者疗效的影响[J].医学信息,2016,29(5):229.
[2]张丽,孟繁琴.2型糖尿病采用甘精胰岛素治疗的效果分析[J].医学信息,2016,29(7):163-164.
[3]李法宁,陈原,匡平,等.2种口服降糖药物联合胰岛素治疗初诊2型糖尿病的临床对比研究[J].中国医院药学杂志,2017,37(3):270-272.
[4]王英杰.2型糖尿病患者血脂检验的临床意义[J].临床合理用药杂志,2014,7(11):105.
[5]马玉青,高丽,潘丽娜.2型糖尿病胰岛素强化治疗患者的低血糖原因分析及护理[J].糖尿病新世界,2015(22):125-127.
[6]张桦.口服降糖药联合甘精胰岛素治疗门诊2型糖尿病的疗效分析[J].实用临床医药杂志,2017,21(21):170-172.
[7]陈湖海,黄涛,孙慧伶,等.甘精胰岛素联合不同降糖药稳定2型糖尿病血糖水平的效果[J].现代生物医学进展,2016,16(29):5684-5687.
[8]孔亚坤,耿秀琴,周艳红,等.甘精胰岛素与西格列汀联用治疗口服降糖药控制不佳的老年2型糖尿病的有效性和安全性[J].中国药师,2016,19(4):695-697.

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更新日期/Last Update: 2018-09-15