[1]郑文灿,法艳梅,吕亚青,等.苦参碱抗肿瘤机制的分子生物学研究进展[J].医学信息,2018,31(19):51-53.[doi:10.3969/j.issn.1006-1959.2018.19.017]
 ZHENG Wen-can,FA Yan-mei,LV Ya-qing,et al.Advances in Molecular Biology of Matrine Antitumor Mechanism[J].Medical Information,2018,31(19):51-53.[doi:10.3969/j.issn.1006-1959.2018.19.017]
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苦参碱抗肿瘤机制的分子生物学研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年19期
页码:
51-53
栏目:
综述
出版日期:
2018-10-01

文章信息/Info

Title:
Advances in Molecular Biology of Matrine Antitumor Mechanism
文章编号:
1006-1959(2018)19-0051-03
作者:
郑文灿法艳梅吕亚青钱垚鑫张莲卿张 烨陶铁梅柴 路
云南省曲靖市第一人民医院药械部,云南 曲靖 655000
Author(s):
ZHENG Wen-canFA Yan-meiLV Ya-qingQIAN Yao-xinZHANG Lian-qingZHANG YeTAO Tie-mei CHAI Lu
Department of Pharmaceutical Machinery,the First People’s Hospital of Qujing,Qujing 655000,Yunnan,China
关键词:
苦参碱肿瘤分子生物学研究
Keywords:
MatrineTumorMolecular biology research
分类号:
R966
DOI:
10.3969/j.issn.1006-1959.2018.19.017
文献标志码:
A
摘要:
苦参碱属于我国纯天然生物碱类药物之一,其药理作用广,特别在抗肿瘤方面越来越受到人们的关注。大量的研究表明其可通过抑制肿瘤细胞的增殖,诱导肿瘤细胞的凋亡,阻滞细胞周期的进展,抑制端粒酶的活性,逆转肿瘤细胞的耐药性,抑制肿瘤细胞的转移作用,抑制肿瘤血管的生成,提高对化疗药物的敏感性等发挥抗肿瘤作用。本文就苦参碱的上述抗肿瘤机制研究进展作一综述,为苦参碱的进一步开发与应用提供理论依据。
Abstract:
Matrine is one of the pure natural alkaloids in China,and its pharmacological effects are wide,especially in the field of anti-tumor.A large number of studies have shown that it can inhibit tumor cell proliferation,induce tumor cell apoptosis,arrest cell cycle progression, inhibit telomerase activity,reverse tumor cell resistance,inhibit tumor cell metastasis,and inhibit the formation of tumor blood vessels,and the sensitivity to chemotherapy drugs play an anti-tumor effect.In this paper,the research progress of the above anti-tumor mechanism of matrine is reviewed,which provides a theoretical basis for the further development and application of matrine.

参考文献/References:

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更新日期/Last Update: 2018-10-29