[1]杨文娟,罗豆豆,石益萌,等.胆囊结石与2型糖尿病的共病机制[J].医学信息,2018,(20):27-31.[doi:10.3969/j.issn.1006-1959.2018.20.009]
 YANG Wen-juan,LUO Dou-dou,SHI Yi-meng,et al.The Comorbid Mechanism of Gallstones and Type 2 Diabetes Mellitus[J].Medical Information,2018,(20):27-31.[doi:10.3969/j.issn.1006-1959.2018.20.009]
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胆囊结石与2型糖尿病的共病机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年20期
页码:
27-31
栏目:
综述
出版日期:
2018-10-15

文章信息/Info

Title:
The Comorbid Mechanism of Gallstones and Type 2 Diabetes Mellitus
文章编号:
1006-1959(2018)20-0027-05
作者:
杨文娟12罗豆豆12石益萌12郝文庆12杜昱和12田竹芳1
1.西安市中心医院内分泌科,陕西 西安 710003;2.延安大学医学院,陕西 延安 716000
Author(s):
YANG Wen-juan12LUO Dou-dou12SHI Yi-meng12HAO Wen-qing12DU Yu-he12TIAN Zhu-fang1
1.Department of Endocrinology,Xi'an Central Hospital,Xi'an 710003,Shaanxi,China;2.School of Medicine,Yan'an University,Yan'an 716000,Shaanxi,China
关键词:
2型糖尿病胆囊结石共病致病因素
Keywords:
Type 2 diabetes mellitusGallstonesComorbidPathogenic factors
分类号:
R587.1;R575.6+2
DOI:
10.3969/j.issn.1006-1959.2018.20.009
文献标志码:
A
摘要:
随着人们生活水平的提高,饮食结构发生转变,胆囊结石及2型糖尿病的发病率逐年上升,且2型糖尿病患者的胆囊结石患病率明显高于其他人群,以往大量研究认为糖尿病是胆囊结石的危险因素。随着研究的深入,发现胆囊结石的发生机制与血脂、胰岛素抵抗及部分脂肪因子因素密切相关,甚至认为胆囊结石是代谢综合征的另一种表现形式。而这些因素在2型糖尿病的发生发展中同样起着重要作用。本文就对胰岛素抵抗、脂代谢、瘦素及脂联素在胆囊结石与2型糖尿病的发病中的作用机制进行综述,并阐明这种共病机制的研究在实际临床工作中的意义。
Abstract:
With the improvement of people's living standards,the diet structure has changed,the incidence of gallstones and type 2 diabetes mellitus has increased year by year,and the prevalence of gallstones in patients with type 2 diabetes mellitus is significantly higher than other people.A large number of studies in the past have suggested that diabetes is a risk factor for gallstones.With the deepening of the research,it is found that the mechanism of gallstone formation is closely related to blood lipids, insulin resistance and some adipokines factors.It is even considered that gallstones are another manifestation of metabolic syndrome.These factors also play an important role in the development of type 2 diabetes mellitus.This article reviews the mechanisms of insulin resistance,lipid metabolism,leptin and adiponectin in the pathogenesis of gallstones and type 2 diabetes mellitus,and clarifies the significance of this comorbidity mechanism in clinical work.

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更新日期/Last Update: 2018-11-09