[1]祝河忠,陈佳娟,童学影,等.过氧化物酶体增生物激活受体激活物对ox-LDL诱导内皮细胞c-fos表达的影响[J].医学信息,2018,(20):58-60.[doi:10.3969/j.issn.1006-1959.2018.20.017]
 ZHU He-zhong,CHEN Jia-juan,TONG Xue-ying,et al.Effect of Peroxisome Proliferator-activated Receptor Activator on c-fos Expression Induced by ox-LDL in Endothelial Cells[J].Medical Information,2018,(20):58-60.[doi:10.3969/j.issn.1006-1959.2018.20.017]
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过氧化物酶体增生物激活受体激活物对ox-LDL诱导内皮细胞c-fos表达的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年20期
页码:
58-60
栏目:
论著
出版日期:
2018-10-15

文章信息/Info

Title:
Effect of Peroxisome Proliferator-activated Receptor Activator on c-fos Expression Induced by ox-LDL in Endothelial Cells
文章编号:
1006-1959(2018)20-0058-03
作者:
祝河忠陈佳娟童学影梁 慧
十堰市太和医院/湖北医药学院附属医院老年医学科,湖北 十堰 442000
Author(s):
ZHU He-zhongCHEN Jia-juanTONG Xue-yingLIANG Hui
Taihe Hospital/Department of Geriatrics,Affiliated Hospital of Hubei Institute of Medicine,Shiyan 442000,Hubei,China
关键词:
内皮细胞c-fos氧化型低密度脂蛋白过氧化物酶体增生物激活受体
Keywords:
Endothelial cellsc-fosOxidized low density lipoproteinPeroxisome proliferator-activated receptor
分类号:
R543.5
DOI:
10.3969/j.issn.1006-1959.2018.20.017
文献标志码:
A
摘要:
目的 观察过氧化物酶体增生物激活受体α激活物K877对氧化型低密度脂蛋白所诱导的人脐静脉内皮细胞c-fos基因表达的影响及机制。方法 体外培养人脐静脉内皮细胞,采取氧化型低密度脂蛋白刺激,应用K877干预,逆转录聚合酶链反应检测c-fos基因的表达。结果 与对照组比较,氧化型低密度脂蛋白组c-fos基因表达增加(P<0.05);与氧化型低密度脂蛋白组比较,K877组c-fos基因表达减少(P<0.05);与K877组比较,K877联合多聚肌甘酸c-fos基因表达进一步下降(P<0.05)。结论 氧化低密度脂蛋白促进了人脐静脉内皮细胞c-fos基因的表达,过氧化物酶体增生物激活受体α激活物K877可抑制c-fos基因的表达,血凝素样氧化型低密度脂蛋白受体1参与了该过程。
Abstract:
Objective To observe the effect and mechanism of peroxisome proliferator-activated receptor α activator K877 on c-fos gene expression in human umbilical vein endothelial cells induced by oxidized low density lipoprotein.Methods Human umbilical vein endothelial cells were cultured in vitro,stimulated with oxidized low density lipoprotein,and K877 was used for intervention. Reverse transcription polymerase chain reaction was used to detect the expression of c-fos gene.Results Compared with the control group,the expression of c-fos gene was increased in the oxidized low density lipoprotein group(P<0.05).Compared with the oxidized low density lipoprotein group,the expression of c-fos gene was decreased in the K877 group(P<0.05).Compared with the K877 group,the expression of K877 combined with poly-clinic acid c-fos gene was further decreased(P<0.05).Conclusion Oxidized low density lipoprotein promotes the expression of c-fos gene in human umbilical vein endothelial cells.Peroxisome proliferator-activated receptor α activator K877 can inhibit the expression of c-fos gene and hemagglutinin-like oxidation.Low density lipoprotein receptor 1 is involved in this process.

参考文献/References:

[1]牛镜磊.新型炎症标志物在动脉粥样硬化中的研究进展[J].中国循环杂志,2017,32(5):516-517. [2]Rafieian-Kopaei M,Setorki M,Doudi M.Atherosclerosis:Proces,Indicators,Risk Factors and New Hopes[J].Int J Prev Mde,2014,5(8):927-946. [3]胡越,许军,刘燕华,等.PPARα激动剂降血脂作用的研究进展[J].中国药科大学学报,2016,47(1):118-124. [4]张立功,王立俊,刘海燕,等.OxLDL/LOX-1系统及NF-κB通路在糖尿病血管内皮功能障碍中的作用机制[J].中华内分泌代谢杂志,2012,28(7):589-592. [5]Chen HB,Wang L,Jiang JF.Re-analysis of expression profiles for revealing new potential candidate genes of heart failure[J].Eur Rev Med Pharmacol Sci,2013,17(7):903-911. [6]张田宁,周美启,吴生兵,等.不同干预方法对心肌缺血c-fos基因表达的影响[J].世界中西医结合杂志,2013,8(6):630-632. [7]王玉,张慧,侯静波.凝集素样氧化低密度脂蛋白受体1对动脉粥样硬化血管细胞作用的研究进展[J].中华老年心脑血管病杂志,2017,19(2):211-213. [8]Collaboration CTT,Fulcher J, O'Connell R,et al.Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials[J].Lancet,2015,385(9976):1397-1405. [9]Ishibashi S,Yamashita S,Arai H,et al.Effects of K-877,a novel selective PPARα modulator(SPPARMα),in dyslipidaemic patients:A randomized,double blind,active-and placebo-controlled,phase 2 trial[J].Atherosclerosis,2016,249(2):36-43.

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更新日期/Last Update: 2018-11-09