[1]巫 娟,张 峰,郭 莉.VEGF与b-FGF在不同病因缺血性坏死股骨头中的表达及意义[J].医学信息,2018,31(20):78-80,85.[doi:10.3969/j.issn.1006-1959.2018.20.022]
　WU Juan,ZHANG Feng,GUO Li.Expression and Significance of VEGF and b-FGF in Avascular Necrosis of Femoral Head with Different Etiology[J].Medical Information,2018,31(20):78-80,85.[doi:10.3969/j.issn.1006-1959.2018.20.022]
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VEGF与b-FGF在不同病因缺血性坏死股骨头中的表达及意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年20期
页码:
78-80,85
栏目:
论著
出版日期:
2018-10-15

文章信息/Info

Title:
Expression and Significance of VEGF and b-FGF in Avascular Necrosis of Femoral Head with Different Etiology
文章编号:
1006-1959（2018）20-0078-04
作者:
巫 娟; 张 峰; 郭 莉
四川省骨科医院病理科，四川 成都 610041
Author(s):
WU Juan; ZHANG Feng; GUO Li
Department of Pathology,Sichuan Orthopaedic Hospital,Chengdu 610041,Sichuan,China
关键词:
股骨头坏死; 血管内皮细胞生长因子; 碱性成纤维细胞因子
Keywords:
Femoral head necrosis; Vascular endothelial growth factor; Basic fibroblast factor
分类号:
R684
DOI:
10.3969/j.issn.1006-1959.2018.20.022
文献标志码:
A
摘要:
目的 研究VEGF和b-FGF在不同病因股骨头缺血性坏死中的表达及意义，为临床针对不同病因ANFH进行个性化防治提供理论依据。方法 选择四川省骨科医院2015年1月~2018年12月因股骨头缺血性坏死行人工全髋关节置换术的股骨头为标本30例设为实验组，并按致病原因分为激素组、酒精组、特发组各10例，另选取股骨颈骨折置换的股骨头10例做为对照组，分别观察其VEGF和b-FGF的表达情况。结果 各实验组及对照组均可见VEGF及b-FGF的阳性表达。实验组阳性面积百分比均低于对照组，差异有统计学意义（P＜0.05），实验组间阳性面积百分比比较，差异无统计学意义（P＞0.05）。结论 股骨头缺血性坏死中VEGF与bFGF表达降低，提示细胞因子与股骨头坏死的修复有密切联系，且不同原因ANFH其致病机制可能相似。
Abstract:
Objective To study the expression and significance of VEGF and b-FGF in avascular necrosis of femoral head with different etiology,and to provide a theoretical basis for clinical prevention and treatment of different causes of ANFH.Methods A total of 30 cases of femoral head with artificial total hip arthroplasty due to avascular necrosis of the femoral head were selected from the experimental group of Sichuan Provincial Orthopaedic Hospital from January 2015 to December 2018.The patients were divided into hormone group,alcohol group and idiopathic group(n=10)according to the causes of the disease,and 10 cases of femoral head replacement for femoral neck fracture were selected as control group.The expression of VEGF and b-FGF were observed separately. Results The positive expressions of VEGF and b-FGF were observed in all experimental groups and control groups.The percentage of positive area in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05). There was no significant difference in the percentage of positive area between the experimental groups(P>0.05).Conclusion The expression of VEGF and bFGF in avascular necrosis of the femoral head is decreased,suggesting that cytokines are closely related to the repair of femoral head necrosis.The pathogenesis of ANFH may be similar for different reasons.

参考文献/References:

[1]谭桢.成人股骨头缺血性坏死的研究进展[J].中国临床新医学,2012,5(10):982-986. [2]韩献波,付保恩.保留股骨头手术治疗中年股骨头缺血性坏死患者的临床效果分析[J].河南医学研究，2018,27(1):91-92. 3]中国医师协会骨科医师分会显微修复工作委员会,中国修复重建外科专业委员会骨缺损及骨坏死学组，中华医学会显微修复学组.成人股骨头坏死临床诊疗指南(2016)[J].中华骨科杂志,2016,36(15): 945-954. [4]吴洪亮,段平国,刘德明.细胞因子治疗激素性股骨头坏死的研究进展[J].南昌大学学报(医学版)，2011,51(11):84-87,91. [5]胡志明,王海彬,李祖国,等.血管内皮细胞生长因子促进激素性股骨头坏死修复[J].中国矫形外科杂志,2006,14(15):1179-1181. [6]钟刚,裴福兴.血管内皮生长因子基因转染促进成骨细胞增值及其功能的实验研究[J].四川大学医学报,2006,37(1):44-47. [7]Kim HK,Bian H,Randall T,et al.Increased VEGF xpression in the epiphyseal cartilage after ischemic necrosis of the capital femoral piphysis[J].Bone Miner Res,2004,19(12):2041-2048. [8]靳松,沈靖男,王晋,等.碱性成纤维细胞生长因子和骨形态发生蛋白对股骨头坏死修复过程的研究[J].中华实验外科杂志,2006,23(9):1142-1143. [9]Moursi AM,Winnard PL,Winnard AV,et al.Fibroblast growth factor-2 induces increased calvarial osteoblast proliferation and cranial suture fusion[J].Cleft Palate Craniofac J,2002,39(5):487 -496. [10]康武林,袁普卫.股骨头缺血性坏死与骨髓间充质干细胞移植研究进展[J].中国矫形外科杂志，2013,21(19):1954-1957. [11]王本超,陈森,方洪.双侧酒精性股骨头坏死合并肱骨头坏死[J].中国骨与关节损伤杂志,2017, 32(11):1228-1229. [12]杨帆,朱振中,李广冀.股骨头坏死病理形态学研究进展[J].国际骨科学杂志,2014(5):313-315. [13]朱蜀云，马素英.马在山主任医师治疗股骨头缺血性坏死的经验总结[J].中国中医急症，2018，27(3)：524-527.

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更新日期/Last Update: 2018-11-09