[1]右美托咪定预充对体外循环下心脏手术患者肾功能的影响.右美托咪定预充对体外循环下心脏手术患者肾功能的影响[J].医学信息,2018,(20):131-133.[doi:10.3969/j.issn.1006-1959.2018.20.039]
 ZHANG Ya-jing,LU Shu-jun,QI Qing-ling.Effect of Dexmedetomidine Prefilled on Renal Function in Patients undergoing Cardiac Surgery under Cardiopulmonary Bypass[J].Medical Information,2018,(20):131-133.[doi:10.3969/j.issn.1006-1959.2018.20.039]
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右美托咪定预充对体外循环下心脏手术患者肾功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年20期
页码:
131-133
栏目:
药物与临床
出版日期:
2018-10-15

文章信息/Info

Title:
Effect of Dexmedetomidine Prefilled on Renal Function in Patients undergoing Cardiac Surgery under Cardiopulmonary Bypass
文章编号:
1006-1959(2018)20-0131-03
作者:
右美托咪定预充对体外循环下心脏手术患者肾功能的影响
1.天津中医药大学第一附属医院麻醉科,天津 300000;2.天津市第一中心医院,天津 300192
Author(s):
ZHANG Ya-jing1LU Shu-jun2QI Qing-ling1
1.Department of Anesthesiology,the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300000,China;2.Tianjin First Central Hospital,Tianjin 300192,China
关键词:
右美托咪定体外循环预充液肾功能
Keywords:
DexmedetomidineCardiopulmonary bypassPrefilledRenal function
分类号:
R614
DOI:
10.3969/j.issn.1006-1959.2018.20.039
文献标志码:
A
摘要:
目的 探讨体外循环过程中,预充右美托咪定对心脏手术患者肾功能的影响。方法 2014年1月~2017年1月于天津市第一中心医院择期行CPB心脏直视手术患者86例,随机分为对照组(C组)与观察组(D组),各43例。D组预充液加右美托咪定注射液1 μg/kg,C组预充液加等量生理盐水。在转机前(T0),转机后10 min(T1),升主动脉阻断后10 min(T2),升主动脉开放后10 min(T3),CPB结束后(T4)抽取血样检测NGAL、Cys-C和β2-MG;在各时间点经食道超声监测两组患者肾动脉内径、肾动脉平均血流速度和肾血流量。结果 ①与T0比较,T3、T4时两组患者NGAL均升高,差异有统计学意义(P<0.05);T4时C组NGAL水平高于D组,差异有统计学意义(P<0.05);②与T0比较,T3、T4时两组患者Cys-C均升高,差异有统计学意义(P<0.05);但两组间Cys-C水平各时间点比较,差异无统计学意义(P>0.05);③与T0比较,T2、T3和T4两组β2-MG均升高,差异有统计学意义(P<0.05);且T2、T3和T4时,D组患者β2-MG水平均低于C组,差异有统计学意义(P<0.05);④D组患者动脉平均血流速度在T3、T4时均高于T0时,差异有统计学意义(P<0.05),肾血流量在T2、T3和T4时均高于T0时,差异有统计学意义(P<0.05);T3、T4时刻,D组患者肾动脉平均血流速度均高于C组,差异有统计学意义(P<0.05); T2、T3和T4时刻,D组患者肾血流量均高于C组,差异有统计学意义(P<0.05)。结论 右美托咪定对CPB下心脏手术围术期肾功能具有保护作用,可有效抑制肾脏损伤,维持肾血流动力学稳定,提高围术期安全性。
Abstract:
Varicocele is a common male reproductive system disease that is an important cause of male infertility.At present,there are many treatment methods for clinical application,and different treatment methods are applicable to different types of patients and e

参考文献/References:

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更新日期/Last Update: 2018-11-09