参考文献/References:
[1]Altekruse SF,McGlynn KA,Reichman ME.Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005 [J].Journal of clinical oncology:official journal of American Society of Clinical Oncology,2009,27(9):1485-1491.
[2]Siegel RL,Miller KD,Jemal A.Cancer statistics, 2016[J].Ca- Cancer J Clin. 2016(66):7-30.
[3]Williams R.Global challenges in liver disease[J].Hepatology,2006,44(3):521-526.
[4]Jemal A,Bray F,Melissa M,et al.Global Cancer Statistics [J].Ca-Czncer J Clin 2011,61(2):69-90.
[5]Farazi PA,DePinho RA.Hepatocellular carcinoma pathogenesis: from genes to environment[J]. Nat Rev Cancer,2006,6(9):674-687.
[6]Hernandez-Vargas H,Lambert MP,Le Calvez-Kelm F,et al.Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors[J].PLoS ONE,2010,5(3): e9749.
[7]Hartwell LH,Kastan MB.Cell cycle control and cancer[J].Science,1994,266(5192):1821-1828.
[8]Chao Y,Shih YL,Chiu JH,et al.Overexpression of cyclin A but not Skp 2 correlates with the tumor relapse of human hepatocellular carcinoma[J].Cancer Res,1998,58(5):985-990.
[9]周奇,梁力建,王广田,等.Cyclin A在肝细胞癌中的表达及其意义[J].肿瘤学杂志，2003,9(6):363-365.
[10]Kim DH,Park SE,Kim M,et a1.A Functional Single Nucleotide Polymorphism at the Promoter Region of Cyclin A2 is Associated With Increased Risk of Colon,Liver,and Lung Cancers[J].Cancer,2011,117(17):4080-4091．
[11]Sherr CJ.Mammalian G1 cyclins[J].Cell,1993,73(6):1059-1065.
[12]Wang J,Chenivesse X,Henglein B,et al.Hepatis B virus integration in a cyclin A gene in a hepatocellular carcinoma[J].Nature,1990,343(6258):555-557.
[13]Bendris N,Lemmers B,Blanchard JM.Cyclin A2 Mutagenesis Analysis: A New Insight into CDK Activation and Cellular Localization Requirements[J].PLoS ONE,2011,6(7):e22879.
[14]Gheghiani L,Loew D,Lombard B,et al.PLK1 Activation in Late G2 Sets Up Commitment to Mitosis[J]. Cell Rep,2017,19(10):2060-2073.
[15]Deng H,Cheng Y,Guo Z,et al.Overexpression of CyclinA2 ameliorates hypoxia-impaired proliferation of cardiomyocytes[J].Exp Ther Med,2014,8(5):1513-1517.
[16]Li HP,Ji JF,Hou KY,et al.Prediction of recurrence risk in early breast cancer using human epidermal growth factor 2 and cyclinA2[J].Chin Med J ( Engl),2010,23(4):431-437．
[17]Mrena J,Wiksten JP,Kokkola A,et al.Prognostic significance of cyclin A in gastric cancer [J].International Journal of Cancer,2006,119(8):1897-1901.
[18]Li JQ,Miki H,Wu F,et al.Cyclin a correlates with carcinogenesis and metastasis,and p27 correlates with lymphatic invasion, in colorectal neoplasms[J].Human pathology,2002,33(10): 1006-1015.
[19]Hung YH,Huang HL,Chen WC,et al.Argininosuccinate lyase interacts with cyclin A2 in cytoplasm and modulates growth of liver tumor cells[J].Oncol Rep,2017,37(2):969-978.
[20]Feng W,Cai D,Zhang B,et al.Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells[J]. Biomed Pharmacother,2015(74):257-264.
[21]Ye Q,Lei L,Aili AX.Identification of potential targets for ovarian cancer treatment by systematic bioinformatics analysis[J].Eur J Gynaecol Oncol,2015,36(3):283-289.
[22]Zhao GX,Xu LH,Pan H,et al.The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling[J].Oncotarget,2015, 6(36):38952 -38966.
[23]Gao C,Liang C,Nie Z,et al.Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway[J].Int J Clin Exp Med,2015,8(4):5287-5294.
[24]Wang DG,Fan JB,Siao CJ,et al.Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome[J].Science,1998,280(5366):1077-1082.
[25]张益,彭海志,裘国强,等.周期蛋白A在原发性肝癌中的表达及意义[J].中华肿瘤杂志,2002,24(4）：353-355.