[1]杨锦龙,刘 欢.甲状腺激素测定在高血压心力衰竭患者中的临床意义[J].医学信息,2018,(22):96-99.[doi:10.3969/j.issn.1006-1959.2018.22.026]
 YANG Jin-long,LIU Huanc.Clinical Signifcance of Changes of Serum Thyroid Hormone Levels in Hypertensive Patients with Chronic Heart Failure[J].Medical Information,2018,(22):96-99.[doi:10.3969/j.issn.1006-1959.2018.22.026]
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甲状腺激素测定在高血压心力衰竭患者中的临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
期数:
2018年22期
页码:
96-99
栏目:
论著
出版日期:
2018-11-15

文章信息/Info

Title:
Clinical Signifcance of Changes of Serum Thyroid Hormone Levels in Hypertensive Patients with Chronic Heart Failure
文章编号:
1006-1959(2018)22-0096-04
作者:
杨锦龙1刘 欢2
(四川省乐山市人民医院心血管内科1,内分泌科2,四川 乐山 614000)
Author(s):
YANG Jin-long1LIU Huan2c
(Department of Cardiology1,Department of Endocrinology2,People's Hospital of Leshan,Leshan 614000,Sichuan,China)
关键词:
高血压甲状腺激素心力衰竭正常甲状腺功能病态综合征
Keywords:
HypertensiveThyroid hormoneHeart failureNormal thyroid dysfunction syndrome
分类号:
R541.6;R544.1;R446.11
DOI:
10.3969/j.issn.1006-1959.2018.22.026
文献标志码:
A
摘要:
目的 探讨高血压合并心力衰竭患者体内的甲状腺激素水平变化情况及其临床意义。方法 选择2016年3月~2018年3月收住我院的原发性高血压患者共173例,根据患者是否合并心功能衰竭分为心衰组123例和对照组50例。心衰组患者按NYHA心功能分级标准进行分级,心功能Ⅱ级40例,Ⅲ级48例,Ⅳ级35例。心衰组患者常规予降压及抗心衰治疗,对照组患者仅予降压治疗,观察对比两组患者的甲状腺激素水平、B型利钠肽前体、射血分数水平等指标。比较各组间临床资料,采用Pearson相关性分析甲状腺激素水平与BNP、LVEF的关系。结果 心衰组患者的TT3、FT3、LVEF均低于对照组,差异具有统计学意义(P<0.05),心衰组与对照组TT4、FT4、TSH比较,差异无统计学意义(P>0.05)。随心衰组患者心功能分级的加重,TT3、FT3、LVEF水平呈依次下降趋势,BNP升高,差异有统计学意义(P<0.05)。BNP与TT3、FT3、LVEF呈负相关(r=-0.508、-0.251、-0.283,P<0.01),LVEF与TT3呈正相关(r=0.658,P<0.01)。结论 高血压心力衰竭患者常伴有甲状腺激素代谢紊乱,其中TT3、FT3水平在一定程度上能反映心力衰竭严重程度。
Abstract:
Objective To investigate the change and clinical signifcance of serum thyroid hormone levels in hypertensive patients with chronic heart failure.Methods A total of 173 patients with essential hypertension admitted to our hospital from March 2016 to March 2018 were enrolled. According to whether the patients with heart failure were divided into heart failure group (123 cases) and control group (50 cases). Patients with heart failure were graded according to NYHA cardiac function grading criteria. 40 patients with grade II cardiac function, 48 patients with grade III, and 35 patients with grade IV. Patients in the heart failure group were treated with antihypertensive and anti-heart failure. The patients in the control group were treated with antihypertensive therapy. The thyroid hormone levels, B-type natriuretic peptide precursors, and ejection fraction levels were compared between the two groups. The clinical data of each group were compared, and the relationship between thyroid hormone levels and BNP and LVEF was analyzed by Pearson correlation.Results The TT3, FT3 and LVEF of the patients with heart failure were lower than those of the control group, the difference was statistically significant (P<0.05). There was no significant difference between the heart failure group and the control group TT4, FT4 and TSH (P>0.05). The heart function grading of patients with heart failure group increased, TT3, FT3, LVEF levels decreased in turn, BNP increased, the difference was statistically significant (P<0.05). BNP was negatively correlated with TT3, FT3 and LVEF (r=-0.508,-0.251,-0.283, P<0.01), and LVEF was positively correlated with TT3 (r=0.658, P<0.01). Conclusion Hypertensive heart failure patients are often accompanied by thyroid hormone metabolism disorders, and the levels of TT3 and FT3 can reflect the severity of heart failure to a certain extent.

参考文献/References:


[1]Iervasi G,Nicolini G.Thyroid hormone and cardiovascular system: from basic concepts to clinical application[J].Intern Emerg Med,2013,8(1):71-74.
[2]Krysiak R,Kedzia A,Kowalcze K,et al.Euthyroid sick syndrome:an important clinical problem[J].Wiad Lek,2017,70(2):376-385.
[3]Proplesch M,Merz AA,Claggett BL,et al.Right atrial structure and function in patients with hypertension and with chronic heart failure[J].Echocardiography,2018,35(7):905-914.
[4]唐春春.正常甲状腺功能病态综合征诊治现状[J].医学信息,2013,26(6):709-708.
[5]阚春婷,曹长春.左室射血分数正常、降低的心衰患者血清脑钠肽和甲状腺激素水平对比观察[J].山东医药,2018,58(3):81-82.
[6]Ira Martin Grais,James R.Thyroid and the Heart[J].American Journal of Medicine,2014,127(8):691-698.
[7]Vlachopoulos C,Terentes-Printzios D.Thyroid,aldosterone,and cardiovascular disease[J].Heart and Metabolism,2015(66):3-6.
[8]吕阳,李东文,陈轶楠.老年慢性心衰患者甲状腺激素水平变化的临床研究[J].临床军医杂志,2015,43(8):778-780.
[9]王敏,周白丽.甲状腺激素与心力衰竭[J].医学信息,2011,24(2):822-823.
[10]Alan SG,Dariush M,Véronique LR,et al.Heart disease and stroke statistics-2014 update:a report from the american heart association[J].Circulation,2014,129(3):399-410.
[11]Park BH,Baik SJ,Lee HA,et al.The association of thyroid hormones and blood pressure in euthyroid preadolescents[J].J Pediatr Endocrinol Metal,2016,29(4):459-464.

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更新日期/Last Update: 2018-12-03